Direct immunofluorescence findings in cicatricial alopecia: A retrospective study of 155 cases

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dc.contributor.authorAgarwal, Ren_US
dc.contributor.authorSingh, Men_US
dc.contributor.authorDahiya, Ren_US
dc.contributor.authorSingh, Ven_US
dc.contributor.authorChaudhary, Den_US
dc.contributor.authorKhurana, Nen_US
dc.contributor.authorGarg, VKen_US
dc.date.accessioned2020-04-10T01:49:48Z
dc.date.available2020-04-10T01:49:48Z
dc.date.issued2019-03
dc.description.abstractObjectives: To study the direct immunofluorescence (DIF) in cicatricial alopecia (CA) patients. Materials and Methods: Approximately, 155 skin biopsies from CA patients examined over 7 years (2009–2015). Special stains and Hematoxylin and Eosin were performed, and final histopathological diagnosis was made. DIF (against anti-IgG, IgM, C3, IgA, and fibrinogen) on all these cases and patterns were noted. The descriptive statistics were applied along with ANOVA test. Results: Approximately, 155 patients with Male: Female = 1.24:1, age 7–65 years. In total, 57 cases were of Lichen planopilaris (LPP; 36.7%), 22 Lichen planus (LP; 14.2%), 22 Psuedopalade of Brocq (PPB; 14.2%),16 discoid lupus erythematosus (DLE; 10.3%), 8 end-stage scarring alopecia (ESSA; 5.2%), 2 cases each of Fungal folliculitis (FF), and Folliculitis decalvans (FD; 1.3% each), and in 26 cases, no specific diagnosis could be reached were collectively kept in the category of non-specific findings (NSP; 16.7%). On DIF: LPP positive for IgG = 4 cases (7%), IgM = 26 (45%), IgA = 11 (19.3%), C3 = 16 (28.1%), and fibrinogen = 11 (19.3%). LP positive for IgG = 2 (9%), IgM = 18 (81%), IgA = 2 (9.1%), C3 = 10 (45%), and fibrinogen = 1 (4.5%). DLE positive for IgG = 6 (37%), IgM = 8 (50%), IgA = 1 (6.3%), C3 = 9 (56%), and fibrinogen = 1 (4.5%). Limitations: Because this was a retrospective study, clinical follow-up and treatment history of the patient could not be retrieved. Conclusions: IgG positivity helps significantly in differentiating LPP from DLE (P 0.004) and NSP from DLE (P 0.005). IgM positivity helps significantly in differentiating LPP from LP (P 0.04), LP from PPB (P 0.00) and NSP (P 0.00). C3 positivity helps significantly in differentiating PPB from DLE (P 0.02).en_US
dc.identifier.affiliationsDepartment of Pathology, Maulana Azad Medical College, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Dermatology, Maulana Azad Medical College, New Delhi, Indiaen_US
dc.identifier.citationAgarwal R, Singh M, Dahiya R, Singh V, Chaudhary D, Khurana N, Garg VK. Direct immunofluorescence findings in cicatricial alopecia: A retrospective study of 155 cases. Indian Journal of Pathology and Microbiology. 2019 Mar; 62(1): 103-106en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/196294
dc.languageenen_US
dc.publisherIndian Association of Pathologists and Microbiologistsen_US
dc.relation.issuenumber1en_US
dc.relation.volume62en_US
dc.source.urihttps://dx.doi.org/10.4103/IJPM.IJPM_428_18en_US
dc.subjectAlopeciaen_US
dc.subjectcicatricial alopeciaen_US
dc.subjectDIFen_US
dc.subjectskin biopsyen_US
dc.titleDirect immunofluorescence findings in cicatricial alopecia: A retrospective study of 155 casesen_US
dc.typeJournal Articleen_US
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