Caffeine Topical Gel Formulation

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dc.contributor.authorThanaporn Amnualkiten_US
dc.contributor.authorSuthimaln Ingkatawornwongen_US
dc.contributor.authorDuangkhae Maneenuanen_US
dc.contributor.authorKittichote Worachotekamjornen_US
dc.date.accessioned2011-02-20T04:28:46Z
dc.date.available2011-02-20T04:28:46Z
dc.date.created2010-02-25en_US
dc.date.issued2010-02-25en_US
dc.description.abstractCaffeine was used topically as one of many ingredients in various cosmetic preparations for reducing under-eye puffiness and dark circles. Gels containing 3% w/w caffeine as an active ingredient were prepared in this study. Suitable co-solvent systems and gel-forming concentrations were studied. Their effects on caffeine release from formulation were also studied. Suitable gel formulations consisted of carbopol Ultrez-21 as a gel-forming agent and propylene glycol (PG) as a co-solvent. The result showed that the increased concentration of Carbopol Ultrez-21, affected the formulation and thereby giving higher viscosity. However, all concentrations Carbopol Ultrez-21 studied (0.2%, 0.5%, 1%, 2% and 4%) did not affect caffeine release significantly. The percentage of PG in the formulation greatly affected caffeine release. Formulation containing 15% and 30% w/w PG gave release rate from Higuchi’s equation of 2.47 ± 0.26 mg/cm²/h½ and 2.37 ± 0.17 mg/cm²/h½, respectively which were lower when compared to release rate of 2.67 ± 0.07 mg/cm²/h½ from formulation containing 7.5% w/w PG. The best formulation of caffeine gel with good physical appearance and good release rate comprised of 3% caffeine, 0.5% carbopol Ultrez-21 and 7.5% PG.en_US
dc.identifier.citationIsan Journal of Pharmaceutical Sciences - วารสารเภสัชศาสตร์อีสาน; Volume 4 No.1 January-June 2008; 16-24en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/130676
dc.language.isoen_USen_US
dc.publisherIsan Journal of Pharmaceutical Sciences - วารสารเภสัชศาสตร์อีสานen_US
dc.rightsIsan Journal of Pharmaceutical Sciences - วารสารเภสัชศาสตร์อีสานen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/IJPS/issue/archiveen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/IJPS/article/view/2097en_US
dc.titleCaffeine Topical Gel Formulationen_US
dc.typeOriginal Articlesen_US
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