Teratogenic effects of aqueous extract of Ficus glomerata leaf during embryonic development in zebrafish (Danio rerio)

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dc.contributor.authorAbusufyan, Shaikhen_US
dc.contributor.authorKalidas, Kohaleen_US
dc.contributor.authorMohammed, Ibrahimen_US
dc.contributor.authorKhan, Mohiben_US
dc.date.accessioned2020-10-16T08:56:12Z
dc.date.available2020-10-16T08:56:12Z
dc.date.issued2019-05
dc.description.abstractOver the past few decades, many reports were published in scientific journals describing medicinal properties of Ficusglomerata (FG). However, its effects on embryonic development and its safety characteristics have not been studied.The purpose of this investigation was to determine lethal concentration 50 (LC50) and study the effect of aqueousextract of FG leaf (AEFG) on developmental abnormalities in zebrafish embryos. LC50 value of AEFG was calculatedby using probit analysis. Effect on percentage hatchability, heartbeat rate, total body length, and developmentalmorphological abnormalities, i.e., delayed growth, abnormal movement, tail detachment, abnormal head-trunkangle, scoliosis/flexure, and yolk sac edema were recorded. AEFG revealed LC50 of 239.88 ppm. The result showeda significant reduction in percent hatchability (p < 0.05), heartbeat rate (p < 0.001), total body length (p < 0.001),and developmental morphological abnormalities in the embryos treated with AEFG. This research can be used inconsidering the safety of an AEFG extract for their use during pre-conception or early pregnancy period.en_US
dc.identifier.affiliationsSchool of Pharmacy, Anjuman-I-Islam's Kalsekar Technical Campus, New Panvel, Maharashtra, affiliated to Mumbai University, Mumbai, Indiaen_US
dc.identifier.affiliationsDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, Indiaen_US
dc.identifier.affiliationsPNR College of Pharmacy, Hyderabad, Indiaen_US
dc.identifier.affiliationsOriental College of Pharmacy, Mumbai, Indiaen_US
dc.identifier.citationAbusufyan Shaikh, Kalidas Kohale, Mohammed Ibrahim, Khan Mohib. Teratogenic effects of aqueous extract of Ficus glomerata leaf during embryonic development in zebrafish (Danio rerio). Journal of Applied Pharmaceutical Science. 2019 May; 2019 May: 107-111en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210592
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber5en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2019.90514en_US
dc.subjectFicus glomerataen_US
dc.subjecttoxicity testen_US
dc.subjectteratogenesisen_US
dc.subjectembryogenesis.en_US
dc.titleTeratogenic effects of aqueous extract of Ficus glomerata leaf during embryonic development in zebrafish (Danio rerio)en_US
dc.typeJournal Articleen_US
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