A comparative study on the effect of felodipine and propranolol on serum lipid profile of rabbits.

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dc.contributor.authorSwain, T Ren_US
dc.contributor.authorDas, Men_US
dc.contributor.authorKanungo, Sen_US
dc.contributor.authorMukherji, Den_US
dc.contributor.authorMishra, S Sen_US
dc.contributor.authorDas, M Cen_US
dc.date.accessioned1997-07-01en_US
dc.date.accessioned2009-06-01T07:53:37Z
dc.date.available1997-07-01en_US
dc.date.available2009-06-01T07:53:37Z
dc.date.issued1997-07-01en_US
dc.description.abstractEffect of felodipine on serum lipids of rabbits was studied and was compared with that of propranolol. Lipid parameters were estimated at basal (0 wk), end of 4th and 16th week of diet/drug administration by using standard kits for analysis. There was a significant increase in mean serum cholesterol, TG, VLDLc, LDLC and decrease in HDLc, (P<0.05) in the group of rabbits receiving Atherogenic diet (AD)/Propranolol. This effect was maximally observed in rabbits receiving both AD and propranolol. This change was satisfactorily prevented when felodipine was administered from very beginning (P<0.001). In addition, there was a significant increase in HDLc (28.89%) of rabbits receiving felodipine from beginning. Thus both AD and propranolol have dyslipidemic effect and early administration of felodipine favorably changes all lipid parameters.en_US
dc.description.affiliationP.G. Department of Pharmacology, S.C.B. Medical College, Cuttack.en_US
dc.identifier.citationSwain TR, Das M, Kanungo S, Mukherji D, Mishra SS, Das MC. A comparative study on the effect of felodipine and propranolol on serum lipid profile of rabbits. Indian Journal of Physiology and Pharmacology. 1997 Jul; 41(3): 269-74en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108502
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntihypertensive Agents --pharmacologyen_US
dc.subject.meshAntilipemic Agents --pharmacologyen_US
dc.subject.meshCalcium Channel Blockers --pharmacologyen_US
dc.subject.meshFelodipine --pharmacologyen_US
dc.subject.meshLipids --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshPropranolol --pharmacologyen_US
dc.subject.meshRabbitsen_US
dc.titleA comparative study on the effect of felodipine and propranolol on serum lipid profile of rabbits.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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