Dapsone induced methemoglobinemia : Intermittent vs continuous intravenous methylene blue therapy.

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dc.contributor.authorPrasad, Rajnitien_US
dc.contributor.authorSingh, Ren_US
dc.contributor.authorMishra, O Pen_US
dc.contributor.authorPandey, Madhukaren_US
dc.date.accessioned2008-03-01en_US
dc.date.accessioned2009-05-30T15:43:59Z
dc.date.available2008-03-01en_US
dc.date.available2009-05-30T15:43:59Z
dc.date.issued2008-03-01en_US
dc.description.abstractOBJECTIVE: The study compares the decline in blood methemoglobin (MetHb) level in children of dapsone intoxication treated with intermittent and continuous methylene blue therapy. METHODS: Eleven children with history of accidental dapsone ingestion and suggestive clinical features of dapsone intoxication were studied. Patients were randomized into two groups: Gr I (n=5) received intermittent methylene blue therapy, while Gr II (N=6) as continuous infusion. The dose of methylene blue was same in both groups. MetHb level in blood was assessed by spectrophotometer at admission and thereafter 12hrly up to 72 hrs. The decline in MetHb was statistically analyzed with student t-test. RESULTS: Six patients had history of seizure and altered sensorium. Severe anemia was observed in 2 patients. The mean levels of MetHb in Gr II was statistically significant after 12, 24, 36, 48 and 72 hrs of methylene blue therapy as compared to Gr I. CONCLUSION: Continuous I.V methylene blue therapy causes significant decline in MetHb level and is more effective in treatment of methemoglobinemia as compared to intermittent regimen.en_US
dc.description.affiliationDepartment of Pediatrics, Institute of Medical Sciences, BHU, Varanasi, Uttar Pradesh, India. rajniti_prasad@hotmail.comen_US
dc.identifier.citationPrasad R, Singh R, Mishra OP, Pandey M. Dapsone induced methemoglobinemia : Intermittent vs continuous intravenous methylene blue therapy. Indian Journal of Pediatrics. 2008 Mar; 75(3): 245-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/83898
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAnti-Infective Agents --poisoningen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDapsone --poisoningen_US
dc.subject.meshEnzyme Inhibitors --administration & dosageen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfusions, Intravenousen_US
dc.subject.meshMaleen_US
dc.subject.meshMethemoglobinemia --chemically induceden_US
dc.subject.meshMethylene Blue --administration & dosageen_US
dc.titleDapsone induced methemoglobinemia : Intermittent vs continuous intravenous methylene blue therapy.en_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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