Evaluation of lymphocyte proliferation assay to purified protein derivative, enzyme linked immunosorbant assay, and tuberculin hypersensitivity in Eales' disease.

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dc.contributor.authorBiswas, Jen_US
dc.contributor.authorNarain, Sen_US
dc.contributor.authorRoy, Sen_US
dc.contributor.authorMadhavan, H Nen_US
dc.date.accessioned1997-06-01en_US
dc.date.accessioned2009-05-29T08:34:17Z
dc.date.available1997-06-01en_US
dc.date.available2009-05-29T08:34:17Z
dc.date.issued1997-06-01en_US
dc.description.abstractThe purpose of this study was to evaluate the immunological responses against mycobacterial antigens in Eales' disease. Fifty six patients with Eales' disease and fifty age-and-sex-matched healthy volunteers with normal fundus findings taken as controls, were subjected to Mantoux test, using 2 TU/0.1 ml of purified protein derivative (PPD), lymphocyte proliferation assay to PPD, and ELISA to detect IgM and IgG antibodies against mycobacterial A-60 antigen. The results of Mantoux test and lymphocytes proliferation assay did not differ significantly in the two groups suggesting a similar cellular immune response. The number of individuals with recent exposure/reexposure to tuberculosis (IgM+) was significantly higher among patients. However the number of people with past exposure (IgM-IgG+) was significantly higher among controls. Our study indicates that there are no statistically significant differences in the humoral and cellular immune responses to mycobacterial antigens between the patients with Eales' disease and controls, except for a significantly higher IgM positivity among the patients.en_US
dc.description.affiliationMedical and Vision Research Foundation, Chennai, India.en_US
dc.identifier.citationBiswas J, Narain S, Roy S, Madhavan HN. Evaluation of lymphocyte proliferation assay to purified protein derivative, enzyme linked immunosorbant assay, and tuberculin hypersensitivity in Eales' disease. Indian Journal of Ophthalmology. 1997 Jun; 45(2): 93-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/70625
dc.language.isoengen_US
dc.source.urihttps://www.ijo.inen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAntibodies, Bacterial --analysisen_US
dc.subject.meshAntigens, Bacterial --immunologyen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypersensitivity, Delayed --immunologyen_US
dc.subject.meshImmunoglobulin G --analysisen_US
dc.subject.meshImmunoglobulin M --analysisen_US
dc.subject.meshLymphocyte Activation --immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMycobacterium tuberculosis --immunologyen_US
dc.subject.meshRetinal Diseases --immunologyen_US
dc.subject.meshTuberculin --immunologyen_US
dc.subject.meshTuberculin Testen_US
dc.subject.meshTuberculosis, Ocular --immunologyen_US
dc.subject.meshVasculitis --immunologyen_US
dc.titleEvaluation of lymphocyte proliferation assay to purified protein derivative, enzyme linked immunosorbant assay, and tuberculin hypersensitivity in Eales' disease.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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