Predictive effects of a combined indicator in patients with hepatocellular carcinoma after thermal ablation

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dc.contributor.authorYang, Qien_US
dc.contributor.authorYu, Xiao-lingen_US
dc.contributor.authorWang, Yingen_US
dc.contributor.authorCheng, Zhi-gangen_US
dc.contributor.authorHan, Zhi-yuen_US
dc.contributor.authorLiu, Fang-yien_US
dc.contributor.authorQian, Tong-gangen_US
dc.contributor.authorYu, Jieen_US
dc.contributor.authorLiang, Pingen_US
dc.date.accessioned2020-11-18T10:08:13Z
dc.date.available2020-11-18T10:08:13Z
dc.date.issued2020-09
dc.description.abstractAim: This study aimed to investigate the predictive power of the combination of Systemic Immune-Inflammation Index (SII) and albumin-bilirubin (ALBI) grade in prognosis outcomes of early-stage hepatocellular carcinoma (HCC) after thermal ablation. Materials and Methods: This retrospective study was reviewed and approved by our institutional review board, and written informed consent was obtained from each patient. According to the Milan criteria, a total of 405 treatment-naïve patients with clinicopathologically confirmed HCC were enrolled who subsequently underwent thermal ablation from 2011 to 2016. The outcomes of overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were statistically analyzed. Results: The median follow-up time of this study was 45.1 months (range, 1.3–83.2 months). After thermal ablation in patients with SII-ALBI Grades 1, 2, and 3, the cumulative 5-year OS rates were 81.7%, 63.2%, and 26.9%; the 5-year CSS rates were 82.4%, 67.5%, and 26.9%; and the 5-year RFS rates were 49.3%, 44.6%, and 25.3%, respectively (all P < 0.001). On multivariate Cox regression analyses, SII-ALBI was independently associated with the three outcomes after adjustment for various confounders (all P < 0.05). In addition, SII-ALBI played a predictive role in OS, CSS, and RFS for patients with negative alpha-fetoprotein (AFP) (P < 0.05). Compared with SII and ALBI, the AUCs for the prediction of OS and CSS using SII-ALBI were superior to single indicator (bothP < 0.05). Conclusion: Elevated preablation SII-ALBI is associated with shorter OS, CSS, and RFS in patients with early-stage HCC. Our indicator showed the potential to be a supplement tool for patients with negative AFP during follow-upen_US
dc.identifier.affiliationsDepartment of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, Chinaen_US
dc.identifier.affiliationsDepartment of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, Chinaen_US
dc.identifier.affiliationsDepartment of Ultrasound, The Second Affiliated Hospital of Qiqihar Medical College, Qiqihar, Chinaen_US
dc.identifier.affiliationsDepartment of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, Chinaen_US
dc.identifier.affiliationsDepartment of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, Chinaen_US
dc.identifier.affiliationsDepartment of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, Chinaen_US
dc.identifier.affiliationsDepartment of Ultrasound, Zunhua People's Hospital, Hebei Province, Zunhua 064200, Chinaen_US
dc.identifier.affiliationsDepartment of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, Chinaen_US
dc.identifier.affiliationsDepartment of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, Chinaen_US
dc.identifier.citationYang Qi, Yu Xiao-ling, Wang Ying, Cheng Zhi-gang, Han Zhi-yu, Liu Fang-yi, Qian Tong-gang, Yu Jie, Liang Ping. Predictive effects of a combined indicator in patients with hepatocellular carcinoma after thermal ablation. Journal of Cancer Research and Therapeutics. 2020 Sep; 16(5): 1038-1050en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213751
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber5en_US
dc.relation.volume16en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_1080_19en_US
dc.subjectAlbumin-bilirubin gradeen_US
dc.subjecthepatocellular carcinomaen_US
dc.subjectprognosisen_US
dc.subjectSystemic Immune-Inflammation Indexen_US
dc.subjectthermal ablationen_US
dc.subjectultrasounden_US
dc.titlePredictive effects of a combined indicator in patients with hepatocellular carcinoma after thermal ablationen_US
dc.typeJournal Articleen_US
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