Predictive effects of a combined indicator in patients with hepatocellular carcinoma after thermal ablation
dc.contributor.author | Yang, Qi | en_US |
dc.contributor.author | Yu, Xiao-ling | en_US |
dc.contributor.author | Wang, Ying | en_US |
dc.contributor.author | Cheng, Zhi-gang | en_US |
dc.contributor.author | Han, Zhi-yu | en_US |
dc.contributor.author | Liu, Fang-yi | en_US |
dc.contributor.author | Qian, Tong-gang | en_US |
dc.contributor.author | Yu, Jie | en_US |
dc.contributor.author | Liang, Ping | en_US |
dc.date.accessioned | 2020-11-18T10:08:13Z | |
dc.date.available | 2020-11-18T10:08:13Z | |
dc.date.issued | 2020-09 | |
dc.description.abstract | Aim: This study aimed to investigate the predictive power of the combination of Systemic Immune-Inflammation Index (SII) and albumin-bilirubin (ALBI) grade in prognosis outcomes of early-stage hepatocellular carcinoma (HCC) after thermal ablation. Materials and Methods: This retrospective study was reviewed and approved by our institutional review board, and written informed consent was obtained from each patient. According to the Milan criteria, a total of 405 treatment-naïve patients with clinicopathologically confirmed HCC were enrolled who subsequently underwent thermal ablation from 2011 to 2016. The outcomes of overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were statistically analyzed. Results: The median follow-up time of this study was 45.1 months (range, 1.3–83.2 months). After thermal ablation in patients with SII-ALBI Grades 1, 2, and 3, the cumulative 5-year OS rates were 81.7%, 63.2%, and 26.9%; the 5-year CSS rates were 82.4%, 67.5%, and 26.9%; and the 5-year RFS rates were 49.3%, 44.6%, and 25.3%, respectively (all P < 0.001). On multivariate Cox regression analyses, SII-ALBI was independently associated with the three outcomes after adjustment for various confounders (all P < 0.05). In addition, SII-ALBI played a predictive role in OS, CSS, and RFS for patients with negative alpha-fetoprotein (AFP) (P < 0.05). Compared with SII and ALBI, the AUCs for the prediction of OS and CSS using SII-ALBI were superior to single indicator (bothP < 0.05). Conclusion: Elevated preablation SII-ALBI is associated with shorter OS, CSS, and RFS in patients with early-stage HCC. Our indicator showed the potential to be a supplement tool for patients with negative AFP during follow-up | en_US |
dc.identifier.affiliations | Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China | en_US |
dc.identifier.affiliations | Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China | en_US |
dc.identifier.affiliations | Department of Ultrasound, The Second Affiliated Hospital of Qiqihar Medical College, Qiqihar, China | en_US |
dc.identifier.affiliations | Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China | en_US |
dc.identifier.affiliations | Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China | en_US |
dc.identifier.affiliations | Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China | en_US |
dc.identifier.affiliations | Department of Ultrasound, Zunhua People's Hospital, Hebei Province, Zunhua 064200, China | en_US |
dc.identifier.affiliations | Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China | en_US |
dc.identifier.affiliations | Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China | en_US |
dc.identifier.citation | Yang Qi, Yu Xiao-ling, Wang Ying, Cheng Zhi-gang, Han Zhi-yu, Liu Fang-yi, Qian Tong-gang, Yu Jie, Liang Ping. Predictive effects of a combined indicator in patients with hepatocellular carcinoma after thermal ablation. Journal of Cancer Research and Therapeutics. 2020 Sep; 16(5): 1038-1050 | en_US |
dc.identifier.issn | 0973-1482 | |
dc.identifier.place | India | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/213751 | |
dc.language | en | en_US |
dc.publisher | Wolters Kluwer India Pvt. Ltd. | en_US |
dc.relation.issuenumber | 5 | en_US |
dc.relation.volume | 16 | en_US |
dc.source.uri | https://dx.doi.org//10.4103/jcrt.JCRT_1080_19 | en_US |
dc.subject | Albumin-bilirubin grade | en_US |
dc.subject | hepatocellular carcinoma | en_US |
dc.subject | prognosis | en_US |
dc.subject | Systemic Immune-Inflammation Index | en_US |
dc.subject | thermal ablation | en_US |
dc.subject | ultrasound | en_US |
dc.title | Predictive effects of a combined indicator in patients with hepatocellular carcinoma after thermal ablation | en_US |
dc.type | Journal Article | en_US |
Files
Original bundle
1 - 1 of 1