Polymorphism of Glutathione S-Transferase Omega 2 and Patient Outcome in Breast Cancer

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dc.contributor.authorSunanta Chariyalertsaken_US
dc.contributor.authorWichai Purisaen_US
dc.contributor.authorPensri Saeleeen_US
dc.date.accessioned2011-02-22T08:15:50Z
dc.date.available2011-02-22T08:15:50Z
dc.date.created2011-02-11en_US
dc.date.issued2011-02-11en_US
dc.description.abstractA new class of glutathione S-transferase enzymes, named omega, (GSTO) has recently been identified and shown to be expressed in various human tissues. Though GSTO1 and GSTO2 polymorphisms have been reported and found to be associated with the risk of certain cancers, their correlation with cancer-patient outcomes has been demonstrated in a very small number of studies. The aim of this study was to evaluate the potential relationship between GSTO2 polymorphism and clinical outcome parameters and the disease-free survival of breast-cancer patients. DNA was extracted from the formalin-fixed, paraffin-embedded breast-cancer tissues of 83 patients; gene polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). No significant association was found between GSTO2 polymorphism and clinical outcome parameters or five-year disease-free patient survival. It was concluded that GSTO2 polymorphism does not influence the clinical outcome or survival of breast cancer patients. (Thai Cancer J 30;4:153-159)en_US
dc.identifier.citationThai Cancer Journal; Vol.30 No.4 October-December 2010; 153-159en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/132397
dc.language.isoen_USen_US
dc.publisherThai Cancer Journalen_US
dc.rightsNational Cancer Institute of Thailand, Bangkok, Thailanden_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/TCJ/issue/archiveen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/TCJ/article/view/5286en_US
dc.titlePolymorphism of Glutathione S-Transferase Omega 2 and Patient Outcome in Breast Canceren_US
dc.typeResearch Articlesen_US
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