Nitrogen and sulphur mustard induced histopathological observations in mouse visceral organs.
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Date
2010-11
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Abstract
Nitrogen mustards (HN) and sulphur mustard (SM) are potent alkylating blister inducing chemical warfare agents. Single 1.0 LD50
dose produced a progressive fall in body weight from second day onwards in all groups of mustard agents exposed animals. Histological
examination of spleen, liver, skin and kidney revealed significant histopathological lesions in nitrogen mustards and sulphur mustard. These
lesions include granulovascular degeneration with perinuclear clumping of the cytoplasm of hepatocytes and renal parenchymal cells. Renal
lesions were characterized by congestion and hemorrhage. The maximum toxic manifestation were noted in spleen and skin of HN-3
exposed mice while sulphur mustard reported maximum toxicity in liver and kidneys. The study suggests both nitrogen mustards and
sulphur mustard to be extremely toxic by percutaneous route based on histopathological observation and can contributed to earlier reported
free radical generation by these toxicants.
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Keywords
Nitrogen mustard, Mechlorethamine, Sulphur mustard, Acute toxicity, Percutaneous, Subcutaneous, Oxidative stress
Citation
Sharma Manoj, Pant S C, Pant J C, Vijayaraghavan R. Nitrogen and sulphur mustard induced histopathological observations in mouse visceral organs. Journal of Environmental Biology. 2010 Nov; 31(6): 891-905.