Study of Cerebrospinal Fluid (CSF) and Clinical and Electrophysiological Features of Hospitalized Patients with Gullain-Barre´ Syndrome.
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Date
2015-09
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Abstract
Background: Since the elimination of poliomyelitis from most part of the world Gullain-Barre'
Syndrome (GBS) has been the leading cause of acute flaccid paralysis which leads to substantial
morbidity and mortality. Though GBS has received a lot of attention in developed countries, there
is a paucity of reports on the GBS from the developing world including Bangladesh. Objective: The
objective of the study was to correlate clinical, cerebrospinal fluid (CSF) and electrophysiological
findings of hospitalized Gullain-Barre´ syndrome patients for early diagnosis and appropriate
management. Materials and Methods: A total of 47 clinically diagnosed GBS patients admitted in
Neurology, Medicine and Pediatrics departments of Dhaka Medical College Hospital (DMCH)
were included in this quasi-experimental study. Biochemical, cytological and bacteriological
studies of CSF of these patients were done. Electrophysiological studies of all subjects were done
and values were compared with upper and lower limits of normal. Results: In this study,
antecedent event were present in 55.30% cases and upper respiratory infection (23.40%) and
gastroenteritis (21.30%) were the commonest antecedent disorders. All the study patients had
numbness or paresthesia and limb weakness, and muscle pain was in 44.7% cases, facial weakness
in 36.2% cases, ophthalmoplegia or ptosis in 6.4% and bulbar involvement was in 6.4% cases.
Most of the patients (95.7%) had deep tendon hypo/areflexia followed by respiratory distress
(21.3%), and ataxia (19.1%). Majority of the study patients (57.4%) required one week time to
develop maximum deficit. Maximum subjects (70.2%) had motor type GBS followed by sensorimotor
type (21.3%), Miller-Fisher type (6.4%) and sensory type (2.1%). Eighty three percent of the
study patients had CSF protein concentration >45 mg/dL with mean ± SD of 71.32 ± 20.20 mg/dL
(37–112 mg/dL). The cell count in CSF was <5 per mm3 in 95.7% of the study patients with mean
±SD cell count of 3.2 ± 1.80/mm3 (2–15 cells per mm3). The mean ± SD time to perform EMG
was 9.4 ± 3.6 days with a range from 5–17 days and the mean ± SD disability grade at that time to
EMG was 3.6 ± 0.9 with a range from 2–5. Regarding the electrodiagnostic types, the commonest
pattern (40.40%) was found AIDP, AMAN was 29.80%, AMSAN 19.15% and mixed pattern was in
10.65% of the patients. Conclusion: This study reveals that clinical, CSF and electrophysiological
findings accurately diagnose the GBS patients along with typing of GBS.
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Keywords
Gullain-Barre´ syndrome, Cerebrospinal fluid, Electrophysiology
Citation
Huda Md Nazmul, Khan Mohammed Momenuzzaman, Azam Bakhtiar, Uddin Md Jalal. Study of Cerebrospinal Fluid (CSF) and Clinical and Electrophysiological Features of Hospitalized Patients with Gullain-Barre´ Syndrome. Journal of Enam Medical College. 2015 Sept; 5(3): 145-150.