Stem cell through present and future.

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dc.contributor.authorSharma, Vijay Ken_US
dc.contributor.authorSingh, Utpal Ken_US
dc.contributor.authorPrasad, Rajnitien_US
dc.contributor.authorFletcher, Sophieen_US
dc.date.accessioned2009-01-12en_US
dc.date.accessioned2009-05-30T14:37:19Z
dc.date.available2009-01-12en_US
dc.date.available2009-05-30T14:37:19Z
dc.date.issued2009-01-12en_US
dc.description.abstractStem cell transplantation (SCT) has the potential to transform the lives of children with a wide variety of genetic diseases, ranging from inherent defects of hemopoietic cell production or function through to metabolic diseases mostly affecting solid organs. For these children life expectancy or quality of life would otherwise be very poor. It ranks as one of the most remarkable therapeutic advances of the past 40 years. Despite rapid technological improvements, however, there are still many short term risks and potential long term toxicities. Consequently, the rapid emergence of alternative therapies (including new drugs, enzyme and gene therapies), necessitate constant re-evaluation of the risk/benefit ratio for each disease and hence the appropriateness of SCT. This review describes the major aspects of the transplant process, indications for transplantation, outcome statistics, and areas where alternative therapies are becoming available. SCT remains a highly experimental therapy. Due to the relatively short history of the discipline no data exists on truly long term follow up. This is important as some organs benefit relatively poorly or problems may emerge which were never apparent as part of the untreated disease. The speed of technological change makes randomised trials on these diseases, which are individually quite rare, almost impossible to perform.en_US
dc.description.affiliationDewsbury District Hospital, Dewbury, UK.en_US
dc.identifier.citationSharma VK, Singh UK, Prasad R, Fletcher S. Stem cell through present and future. Indian Journal of Pediatrics. 2009 Jan; 76(1): 51-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/82832
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshChimerism
dc.subject.meshForecasting
dc.subject.meshGenetic Diseases, Inborn --therapy
dc.subject.meshHumans
dc.subject.meshImmune System Diseases --therapy
dc.subject.meshMetabolism, Inborn Errors --therapy
dc.subject.meshStem Cell Transplantation --methods
dc.subject.meshStem Cell Transplantation --trends
dc.titleStem cell through present and future.en_US
dc.typeJournal Articleen_US
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