Phytochemical Characterization and Anticancer Screening of Cladophora goensis and Cladophora glomerata Extracts

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dc.contributor.authorSundaramoorthy, Sharanyaen_US
dc.contributor.authorDakshinamoorthy, Anushaen_US
dc.contributor.authorL. V. K. S., Bhaskaren_US
dc.date.accessioned2024-12-02T09:58:56Z
dc.date.available2024-12-02T09:58:56Z
dc.date.issued2024-01
dc.description.abstractBackground: Cladophora goensis and Cladophora glomerata has been widely identified in the Indian Oceans. Marine algae have been identified as potential pharmacological agents useful in the treatment of diabetes, hypertension, infections, and cancers. Objectives: The present study aimed to evaluate the phytochemicals in C. goensis and C. glomerata using gas chromatography-mass spectroscopy (GC-MS), and to study the molecular interactions with cancer-related proteins using molecular docking techniques. Materials and methods: GC-MS analysis was done using electron impact ionization at 70eV and the data was evaluated using total ion count for compound identification and quantification. AutoDock 4.0 version was used for the molecular docking analysis. Results: The methanolic extracts of algae when subjected to GC-MS analysis, 19 compounds from C. goensis and 11 phytocompounds from C. glomerata were identified. The significant molecular interactions of phytochemicals of C. goensis (6-nitro-3H-quinazolin-4-one, Isoquinoline, 1,2,3,4-tetrahydro-7-methoxy-2-methyl-8-(phenyl methoxy) and 9-Decen-1-ol, pentafluropropionate) and C. glomerata (phytol, palmitic acid, and octadec-9-enoic acid) against human epidermal growth factor receptor (4WRG), poly (ADP-ribose) polymerase-1 (4UND), human estrogen receptor alpha ligand-binding domain (3ERT), human peroxisome proliferator-activated receptor alpha ligand-binding domain (3VI8), and human topoisomerase (1EJ9) have been demonstrated. Conclusion: The phytochemicals of methanolic extracts of C. goensis and C. glomerata showed potential interactions with cancer-related proteins.en_US
dc.identifier.affiliationsDepartment of Pharmacology, SRMC & RI, Sri Ramachandra Institute of Higher Education and Research-DU, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, SRMC & RI, Sri Ramachandra Institute of Higher Education and Research-DU, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, Indiaen_US
dc.identifier.citationSundaramoorthy Sharanya, Dakshinamoorthy Anusha, L. V. K. S. Bhaskar . Phytochemical Characterization and Anticancer Screening of Cladophora goensis and Cladophora glomerata Extracts. Journal of Pharmacology and Pharmacotherapeutics. 2024 Jan; 15(1): 78 –88en_US
dc.identifier.issn0976-500X
dc.identifier.issn0976-5018
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/239312
dc.languageenen_US
dc.publisherSage Publications India Pvt. Ltd.en_US
dc.relation.issuenumber1en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.1177/0976500X241235721en_US
dc.subjectMarine biologyen_US
dc.subjectpharmacologyen_US
dc.subjectbioinformaticsen_US
dc.subjectcancer biologyen_US
dc.subjectmolecular biologyen_US
dc.titlePhytochemical Characterization and Anticancer Screening of Cladophora goensis and Cladophora glomerata Extractsen_US
dc.typeJournal Articleen_US
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