Alcohol abuse-duration dependent decrease in plasma testosterone and antioxidants in males.

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dc.contributor.authorManeesh, Men_US
dc.contributor.authorDutta, Sanjibaen_US
dc.contributor.authorChakrabarti, Amiten_US
dc.contributor.authorVasudevan, D Men_US
dc.date.accessioned2006-07-30en_US
dc.date.accessioned2009-06-01T08:26:41Z
dc.date.available2006-07-30en_US
dc.date.available2009-06-01T08:26:41Z
dc.date.issued2006-07-30en_US
dc.description.abstractEthanol is a testicular toxin and it causes fertility abnormalities with low sperm count and impaired sperm motility in men. The present study was designed to investigate plasma testosterone level and hypothalamic pituitary gonadal (HPG) axis function in alcoholic men and also effect of ethanol on systemic oxidative stress. Forty six male alcohol abusers in the age group 20-40 years were selected. Fifty five, males in the same age group served as control. Alcohol abusers had significantly low plasma testosterone with low luteinizing hormone and follicle stimulating hormone. In addition they had significantly high thiobarbituric acid reactive substances (TBARS), superoxide dismutase and glutathione S-transferase, and low glutathione, ascorbic acid, catalase, glutathione reductase and glutathione peroxidase. Moreover, serum testosterone level in alcoholics negatively correlated with duration of alcohol abuse, and TBARS. Duration dependent decreased serum testosterone level in alcohol abusers might be due to 1) increased oxidative stress which can damage Leydig and supporting Sertoli cells and 2) impaired HPG axis.en_US
dc.description.affiliationDepartment of Biochemistry, Melaka Manipal Medical College, Manipal 576 104. manu_only@hotmail.comen_US
dc.identifier.citationManeesh M, Dutta S, Chakrabarti A, Vasudevan DM. Alcohol abuse-duration dependent decrease in plasma testosterone and antioxidants in males. Indian Journal of Physiology and Pharmacology. 2006 Jul-Sep; 50(3): 291-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108913
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAlcoholism --blooden_US
dc.subject.meshAntioxidants --analysisen_US
dc.subject.meshCentral Nervous System Depressants --toxicityen_US
dc.subject.meshEthanol --toxicityen_US
dc.subject.meshFollicle Stimulating Hormone --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshLeydig Cells --metabolismen_US
dc.subject.meshLuteinizing Hormone --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshOxidative Stress --drug effectsen_US
dc.subject.meshPituitary Gland --metabolismen_US
dc.subject.meshSertoli Cells --metabolismen_US
dc.subject.meshSperm Counten_US
dc.subject.meshSperm Motility --drug effectsen_US
dc.subject.meshTestosterone --blooden_US
dc.subject.meshTime Factorsen_US
dc.titleAlcohol abuse-duration dependent decrease in plasma testosterone and antioxidants in males.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
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