Human Health Risk Assessment of the Pesticide Simplex with the Active Substances Aminopyralid and Fluroxypyr

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dc.contributor.authorSverdrup, L. E.en_US
dc.contributor.authorBjørge, C.en_US
dc.contributor.authorEklo, O. M.en_US
dc.contributor.authorGrung, M.en_US
dc.contributor.authorKällqvist, T.en_US
dc.contributor.authorKlingen, I.en_US
dc.contributor.authorLåg, M.en_US
dc.contributor.authorRivedal, E.en_US
dc.contributor.authorRopstad, E.en_US
dc.contributor.authorØvrebø, S.en_US
dc.date.accessioned2023-07-14T08:08:10Z
dc.date.available2023-07-14T08:08:10Z
dc.date.issued2022-04
dc.description.abstractSimplex is a new herbicide in Norway containing the active substances aminopyralid and fluroxypyr. Aminopyralid is a new active substance in Norway, but fluroxypyr is found in several authorized products. The application concerns use in established grassland for forage, established ley and pasture and in grass at the first year of sowing. The Norwegian Scientific Committee for Food Safety (VKM) has on a request from the Norwegian Food Safety Authority performed a risk assessment on human health of the active substance and the product. The risk assessment of the product was approved at a meeting May 11 2010 by VKMs Scientific Panel on Pesticides (Panel 2). VKM’s Panel 2 concludes as following: Both Simplex and the active substance aminopyralid are characterized as extremely irritating to the eye based on persistent irritation to the eyes of rabbits. The product Simplex is also found irritating to the rabbit skin. Aminopyralid has low acute toxicity and is not shown to have genotoxic potential, or to be teratogenic or toxic to the reproduction in animals. There may however be a carcinogenic effect of aminopyralid based on an increased number of uterine sarcomas in mice. The main target organs for sub-chronic and chronic toxicity were the caecum (rats), the stomach (dogs, inflammation) and the liver (dogs, hyperthropy). No adverse effects for chronic toxicity were seen in mice. Rabbit was the most sensitive species for toxicity and the no observed effect levels (NOAELs) derived from studies in this species serve as base for calculations of values for acceptable daily intake (ADI) and acceptable operator exposure level (AOEL). The estimated risk for operator is assessed as minimal both by use of boom spraying (46% of AOEL) and knapsack sprayers (81% of AOEL). However, as a result of the hazard classification, a faceshield and gloves are necessary personal protective equipment (PPE) to be worn during mixing and loading operations, due to the risk of serious damage to the eyes and skin irritation.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Det Norske Veritas, Norwayen_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norwegian Enviroment Agency, Norwayen_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norwegian Institute of Bioeconomy Research, Norwayen_US
dc.identifier.affiliationsUniversity of Oslo /Norwegian Scientific Committee for Food Safety (VKM), Norwegian Institute for Water Research, Norwayen_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM),Norwegian Institute of Public Health (FHI), Norwayen_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Oslo University Hospital, Norwayen_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norwegian University of Life Sciences, Norwayen_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), National Institute of Occupational Health, Norway.en_US
dc.identifier.citationSverdrup L. E., Bjørge C., Eklo O. M., Grung M., Källqvist T., Klingen I., Låg M., Rivedal E., Ropstad E., Øvrebø S.. Human Health Risk Assessment of the Pesticide Simplex with the Active Substances Aminopyralid and Fluroxypyr. European Journal of Nutrition & Food Safety. 2022 Apr; 14(4): 1-3en_US
dc.identifier.issn2347-5641
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219568
dc.languageenen_US
dc.publisherSciencedomain Internationalen_US
dc.relation.issuenumber4en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.9734/ejnfs/2022/v14i430488en_US
dc.subjectVKMen_US
dc.subjectassessmenten_US
dc.subjectNorwegian Scientific Committee for Food Safetyen_US
dc.subjectfluroxypyren_US
dc.titleHuman Health Risk Assessment of the Pesticide Simplex with the Active Substances Aminopyralid and Fluroxypyren_US
dc.typeJournal Articleen_US
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