Influence of pretreatment of carbamates on dynamic pulmonary mechanics in rats exposed to sarin aerosols.

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dc.contributor.authorHusain, Ken_US
dc.contributor.authorKumar, Pen_US
dc.contributor.authorVijayaraghavan, Ren_US
dc.contributor.authorSingh, Ren_US
dc.contributor.authorDas Gupta, Sen_US
dc.date.accessioned1993-07-01en_US
dc.date.accessioned2009-06-01T05:30:22Z
dc.date.available1993-07-01en_US
dc.date.available2009-06-01T05:30:22Z
dc.date.issued1993-07-01en_US
dc.description.abstractThe effect of pretreatment of two carbamates, pyridostigmine and physostigmine on dynamic pulmonary mechanics has been studied in rats exposed to sarin aerosols. Sign-free dose of pyridostigmine (0.075 mg/kg, i.m.) or physostigmine (0.1 mg/kg, i.m.) did not significantly alter the parameters of the dynamic pulmonary mechanics 20 min after treatment. However, sarin (51.2 mg/m3, for 15 min) depressed the respiratory rate, air flow and minute volume and enhanced the transthoracic pressure and tidal volume. Pretreatment with carbamates 20 min prior to sarin exposure significantly modified or counteracted the above induced changes. It is concluded that the protective effect of carbamates is mainly due to the correction of respiratory changes caused by sarin aerosols in rats.en_US
dc.description.affiliationDivision of Pharmacology and Toxicology, Defence R & D Establishment, Gwalior.en_US
dc.identifier.citationHusain K, Kumar P, Vijayaraghavan R, Singh R, Das Gupta S. Influence of pretreatment of carbamates on dynamic pulmonary mechanics in rats exposed to sarin aerosols. Indian Journal of Physiology and Pharmacology. 1993 Jul; 37(3): 249-51en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106665
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAerosolsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCarbamates --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPhysostigmine --pharmacologyen_US
dc.subject.meshPyridostigmine Bromide --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshRespiratory Mechanics --drug effectsen_US
dc.subject.meshSarin --administration & dosageen_US
dc.titleInfluence of pretreatment of carbamates on dynamic pulmonary mechanics in rats exposed to sarin aerosols.en_US
dc.typeJournal Articleen_US
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