Browsing by Author "Yan, Yinqiu"
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Item The Role of Twist1 in Stem Cell Differentiation through Mechanical Cues: A Review and Hypothesis.(2016) Yan, Yinqiu; Tian, Zeyun; Guan, Qiuyue; Bai, Ding; Zhang, Jing; Han, XianglongDue to the pivotal role of stem cell differentiation in regeneration and disease cure, the study of it has always been a research highlight during the recent years. Stress microenvironment has a great impact on cell growth, proliferation, differentiation and apoptosis. Twist1, as a core epithelial-mesenchymal transition (EMT) regulatory factor, plays an important role in these processes. Moreover, Twist1 gene can express in alveolar bone – periodontal ligament interface and the expression can be regulated by changes in the occlusal force. In this article, we will present a review of Twist1 gene, especially in the aspect of the biological functions in stem cell differentiation under mechanical signals and explore whether Twist1 involved in tissue remodeling in alveolar bone - periodontal membrane interface under stress.