Browsing by Author "Verma, Saurabh"

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    Effect of sleep on blood pressure among adults of urban slums: A Cross sectional study
    (MRI Publication Pvt. Ltd., 2024-02) Verma, Saurabh; Kumar, Arun; Gautam, Neelam; Mittal, Chhaya
    Introduction: Hypertension, the “Silent, Invisible killer” - is a modern day’s universal epidemic. The adult populations in slum area are more vulnerable for hypertension as they are so busy in the fulfilment of even day to day basic needs and care, family commitments and economic stress. Aim and objectives: To estimate the prevalence of hypertension among the adults (25-44 years) and to study the effect of sleep on blood pressure levels. Methodology: The present cross-sectional study was carried among adults aged between 25 to 44 years residing in the slums of Meerut District. 30 Cluster Sampling technique was used. The slum was selected as a cluster unit. During the visit by house-to-house survey, members of the family were listed and eligible person were interviewed and examined. Data collected on a structured and pretested questionnaire. Results: Prevalence of hypertension among those who had sleep duration of >8 hours per day was 44.8% followed by 20.1% and 17.5% among those who had 7-8 hours and less than 7 hours of sleep time respectively. It was found that 24.2% monophasic sleep pattern follower were hypertensives while the prevalence was 19.4% in biphasic pattern. Conclusion: Majority (55.4%) had a sleep duration between 7-8 hours, followed by 33.9% and 10.7% with <7 hours and >8 hours of sleep time respectively. Majority (61.3%) of the study population were having monophasic sleep pattern, while 36.3% were biphasic and 2.4% were multiphasic.
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    Intraoperative aberrometry-assisted refractive optimization of SFIOL
    (Wolters Kluwer – Medknow, 2025-01) Verma, Saurabh; Venkatesh, Pradeep; Azad, Shorya Vardhan; Kumawat, Devesh; Khokhar, Sudarshan
    Scleral?fixated intraocular lens (SFIOL) is a widely used technique for IOL implantation in patients where capsular support is insufficient. Most surgeons have shifted away from sutured to sutureless SFIOL techniques where haptics of a multifocal IOL are inserted in scleral tunnels/flaps. Large?scale publications have shown wide variation in the refractive status of eyes post?SFIOL even in the best of the hands. This is because even slight variations in the site of scleral flap/tunnel formation and tension on haptics due to the variable length of haptics placed in scleral flaps/tunnels can alter the effective lens position and induce significant residual refractive error, especially cylindrical astigmatism due to IOL tilt. Our technique aims to reduce residual refractive error after SFIOL implantation. This is achieved by using intraoperative aberrometry and adjusting haptics accordingly to achieve minimal refractive error intraoperatively.
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    Malignant nodular hidradenoma with angiolymphatic invasion: a case report.
    (2007-07-22) Singh, Avninder; Sharma, Shruti; Verma, Saurabh; Khanna, Aarti
    Malignant nodular hidradenomas are rare variants of sweat gland carcinomas characterized by aggressive clinical behaviour. We report a case of 42-year-old female with 3 x 2 x 1 cm nodule on her foot followed by cutaneous and regional lymph node metastasis. Flow cytometry showed S-phase fraction of 72.6% and 15.8% of aneuploid cells corroborating with its aggressive nature.
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    Scleral buckling in retinal detachment due to retinal dialysis – A vitreoretina fellow’s perspective
    (Wolters Kluwer – Medknow, 2025-01) Balaji, Akshaya; Verma, Saurabh; Shaikh, Nawazish; Azad, Shorya V; Kumar, Parmanand; Chawla, Rohan; Kumar, Vinod
    Purpose: To analyze the efficacy of scleral buckling in the hands of vitreo?retina (VR) fellows under training in eyes with retinal detachment associated with retinal dialysis and analyze the patient and retinal characteristics in these eyes. Methods: We carried out a retrospective consecutive case review at a tertiary eye care center in North India. Records of all the patients who had undergone scleral buckling (SB) for retinal dialysis?associated rhegmatogenous retinal detachment by VR fellows (with less than 2 years’ experience) between January 2017 and January 2020 were reviewed. Results: Fifty?three eyes of 53 patients with a mean age of 20.77 years were analyzed. Of the patients, 73.58% were males. History of eye trauma was present in 71.69% patients. A total of 21 residents operated these 53 eyes. SB was able to achieve retinal attachment in a single surgery in 84.9% (45/53) eyes. Mean preoperative best corrected visual acuity was 1.9 ± 1.05 log of minimum angle of resolution (logMAR), which improved postoperatively to 1.07 ± 0.72 logMAR (P < 0.001). Surgical success rate was 85.71% (24/28) in eyes with no proliferative vitreoretinopathy (PVR), 66.66% (2/3) in eyes with PVR?A, 91.66% (11/12) in eyes with PVR?B, and 80% (8/10) in eyes with PVR?C1. Fifty?two eyes had a single dialysis and one eye had two separate dialysis. Six eyes had giant retinal dialysis (dialysis greater than 3 clock hours) and all were due to trauma. Five patients had retinal dialysis in the fellow eye and were diagnosed with bilateral idiopathic retinal dialysis. Conclusion: Scleral buckling is a safe and effective management for retinal dialysis retinal detachment even in the hands of VR fellows under training.
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    Serum and salivary interleukin-1? level in oral precancer: An observational study
    (Wolters Kluwer - Medknow, 2024-04) Selvan, T Thamarai; Patil, Ranjit K.; Singh, Vandana; Verma, Saurabh; Tripathi, Anurag; Khanna, Vikram; Chaurasia, Akhilanand; Shetye, Akanksha G.
    Background and Aim: Precancer biomarkers help in early detection and management of oral potentially malignant disorders (OPMDs). Interleukin?1? (IL?1?), a biomarker, is known to be altered in oral submucous fibrosis (OSMF) and oral leukoplakia (OL). Therefore, we evaluated and compared the serum and salivary IL?1? levels in patients with OSMF/oral leukoplakia and in gender? and age?matched healthy individuals. Materials and Methods: An in vivo, prospective, observational study was conducted on 40 subjects. Subjects were divided into two groups with 20 individuals in each group, that is, Group I: OSMF/oral leukoplakia and Group II: control group. Salivary and serum IL?1? levels were quantitatively estimated using enzyme?linked immunosorbent assay (ELISA). The statistical tests used were unpaired t?test and Chi?square test. Results: The serum IL?1? levels were significantly (P 0.001) lesser in Group I in comparison to Group II. The salivary IL?1? levels remained insignificant between both the groups. However, in both the groups, the salivary IL?1? levels were significantly higher compared to the serum IL?1? levels. Conclusion: We found that the serum IL?1? level can be considered as a prospective biomarker for dysplasia, whereas salivary IL?1? alone needs more elaborated studies to account for its application as a potential biomarker in OPMD.
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    Topographic distribution of retinal neovascularization in proliferative diabetic retinopathy using ultra-wide field angiography
    (All India Ophthalmological Society, 2023-08) Nidhi, Vatsala; Verma, Saurabh; Shaikh, Nawazish; Azad, Shorya V; Chawla, Rohan; Venkatesh, Pradeep; Vohra, Rajpal; Kumar, Vinod
    Purpose: To analyze the topographic distribution of neovascularization (NV) and capillary nonperfusion (CNP) using ultra?wide field fluorescein angiography (UWFFA) in patients with proliferative diabetic retinopathy (PDR). Methods: This was a prospective, single?center, observational study in which all patients who presented between March 2019 and December 2020 and satisfied the inclusion criteria were recruited. In our study, patients with treatment?naïve PDR without any fibrovascular proliferation underwent UWFFA. The images were analyzed qualitatively for the topographic distribution of NV and the CNP area was quantified. The number of lesions picked by UWFFA was compared with 7 standard field (7SF) image using overlay of 7SF. The main outcome measure was characteristics of neovascularization, such as the number, location, and area of CNP, measured using UWFFA, which was considered with 95% confidence intervals (CI). Results: Two hundred and fifty?three eyes of 187 patients with a mean age of 56.03 ± 8 years were included. Mean neovascularization elsewhere (NVE) was 2.91 ± 3.43. Maximum NVEs were seen in the superotemporal (ST; 0.9 ± 1.13) quadrant, followed by the inferotemporal (IT; 0.7 ± 1.08), inferonasal (IN; 0.66 ± 1.02) and superonasal (SN; 0.66 ± 1.01) quadrants. Maximum CNP area was seen in the SN (13.75 ± 8.83 disc diameter square [DD2]) quadrant, followed by the IN (13.48 ± 8.59 DD2), IT (11.34 ± 8.37 DD2), and ST (11.3 ± 8.34 DD2) quadrants. Mean CNP area was maximum in patients with only neovascularization of disc (NVD; 64.99 ± 41.47 DD2), followed by both NVD and NVE (61.37 ± 35.61 DD2), and was minimum in patients with only NVE (36.44 ± 22.03 DD2). Eighty?one (32%) eyes out of 253 had NVE and 189 (75%) out of 253 had CNP area outside 7SF (overlay) of Early Treatment Diabetic Retinopathy Study (ETDRS). Conclusion: Diabetic NV lesions and CNP areas are distributed asymmetrically throughout the retina and are not restricted to the posterior pole. Compared to conventional 7SF imaging, UWFFA reveals significantly more retinal vascular pathology in patients with PDR.