Browsing by Author "Verma, R. K."

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    Anti-albuminuric effects of spironolactone and its effect along with ramipril in type-2 diabetic nephropathy
    (Medip Academy, 2019-01) Giri, Richa; Naresh, Ashish; Kushwaha, J. S.; Kumar, Brijesh; Verma, R. K.; Khan, Mohd. Imran
    Background: The study was conducted to evaluate and compare the protective effects of spironolactone (alone) and its effects along with ACE inhibitor (ramipril) on diabetics (30-70year) in relation to proteinuria and state of diabetic nephropathy.Methods: A comparative, prospective, non-randomized, non-blinded experimental study was conducted on 56 patients (30-70year) of diagnosed type 2 diabetes mellitus showing proteinuria. Total duration of study was about one year from October 2017 to October 2018. Patients were divided in two groups, group A (n=28, spironolactone 25mg and ramipril 5mg) and group B (n=27, spironolactone 25mg). Subjects were followed over 12weeks and baseline and 12-week urine ACR being compared.Results: Both the group after receiving respective drug were followed for 3month duration and response were assessed by measuring urine ACR value at end of 3months. Mean values of baseline and follow up urine ACR for group A and group B were 471.5±465.62, 244.66±237.54 and 474.88±438.94, 268.42±268.16 respectively, P value found to be >0.05 at 95%C.I. It was observed that percentage reduction of urine ACR were 48% and 43.47% in group A and group B respectively.Conclusions: In the study, it was concluded that spironolactone had significant effect over proteinuria reduction over follow up period in patient with diabetic nephropathy though there was no additional statistically significant advantage of addition of spironolactone and ACE inhibitor over proteinuria reduction. Significant reduction of proteinuria occurred in both group A and group B over 12weeks follow up period, 48 % reduction in group A and 43.47% in group B. This difference proved statistically not significant after applying independent t-test.
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    Comparative study of dexmedetomidine and clonidine as an adjunct to levobupivacaine in transversus abdominis plane block in patients undergoing total abdominal hysterectomy: a randomized control study
    (Medip Academy, 2019-10) Gupta, Bharti; Gupta, Amit; Verma, R. K.; Shah, Payal
    Background: Ultrasound guided TAP block is safe, simple and effective method of providing postoperative analgesia in surgeries involving abdominal wall incision by blocking anterior branches of thoracolumbar nerves originating from T6-L1. Our aim to study the efficacy of dexmedetomidine and clonidine as an adjunct to levobupivacaine in ultrasound guided TAP block for postoperative analgesia in patients undergoing TAH.Methods: Prospective, double blind randomized control study. Ninety ASA I and II patients scheduled for TAH were randomly assigned in a double blinded study and divided into three groups. Group L received 18ml of 0.25% levobupivacaine+2ml of NS to make total volume of 20ml on each side. Group LC and Group LD received 18ml of 0.25% levobupivacaine + 1 mcg/kg of clonidine or dexmedetomidine diluted in NS to make total volume of 20ml on each side. USG guided TAP block was given when subarachnoid block level regressed to T10 level. Postoperatively patients were assessed for pain scores, HR, SBP, DBP, nausea vomiting, sedation and satisfaction scores at 0, 2, 4, 6 and 12 and 24 hours. Statistical analysis was performed using SPSS software 17. p value<0.05 was considered significant.Results: Pain scores were significantly lower in LD and LC groups as compared to L group and demand for first rescue analgesic was delayed in LD group (491.50±73.29min) and group LC (268.00±35.47min) as compared to group L (129.17±10.67min). The total number of demand doses in 24 hours were significantly less in group LD (1.00±0.00) followed by group LC (2.03±0.18) and group L (2.77±0.57) respectively. Incidence of hypotension, bradycardia and sedation was more in LD group as compared to LC and L groups.Conclusions: TAP block with dexmetomidine as an adjunct to levobupivacaine provides prolonged postoperative analgesia as compared to clonidine as an adjunct and plain levobupivacaine.
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    Radiological features of dengue fever in cases and control
    (Medip Academy, 2022-06) Bajpai, Gautam; Verma, R. K.
    Background:Dengue (pronounced Dengee) fever is a painful, debilitating mosquito-borne disease caused by any one of four closely related dengue viruses. Aim of the study was to study radiological features of dengue fever in cases and control.Methods:Randomized, double blind, placebo controlled, parallel group study conducted among 100 seropositive dengue patients,18-60 years of age (fulfilling inclusion and exclusion criteria) at Lala Lajpat Rai hospital, Kanpur for December2019 October 2021. Selected patients were subjected to history, examination, necessary investigations and then were managed according to national vector borne disease control programme (NVBDCP) guidelines. A total of 100 serology proven dengue patients were included and followed up. Two groups (fifty in each) were allocated by simple first and then systematic random sampling. Case group was given doxycycline and control group was given placebo. Results:USG findings commonly seen in both the cases and control group were hepatomegaly, splenomegaly, ascites right pleural effusion, thickened GB wall and edema. In both the groups, pleural effusion was the most common complication.Conclusions: Ultrasound examinations detected plasma leakage in multiple body compartments around time of defervescence. Presence of plasma leakage in form of ascites and pleural effusion was more in control group as compared to case group seems doxycycline decrease the plasma leakage. Pleural effusion is most common finding ofplasma leakage.
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    Study on Arboreal Floristic Diversity, Phytosociology and Conservation Strategy of Endangered Species in Chandi Beat of Majathal Wildlife Sanctuary, Himachal Pradesh, Western Himalaya
    (Ms. M. B. Mondal, 2023-10) Kumari, Krishna; Verma, R. K.; Kumar, Ranjeet; Thakur, Ashish
    Himachal Pradesh, a land of snow-abode mountains is significant for its natural wealth and unique habitat, flora, and fauna. Majathal Wildlife Sanctuary, the site of the present study was located in Solan and Shimla districts (Wildlife Division, Shimla) of Himachal Pradesh spread over an area of 37.71 sq km. Phytosociological studies for arboreal flora were conducted in the Chandi beat, of the sanctuary by using the quadrate method and quantitative analysis. The altitude of this beat varied from 625m to 1960m amsl. Total number of plant species recorded in the study area was 155, belonging to 46 families and 97 genera. The dominant families included Fabaceae, Moraceae, Asteraceae, Malvaceae, Lamiaceae, and Rosaceae. Pinus roxburghii recorded the highest value of IVI and is the most dominant tree species in the forest followed by Quercus leucotrichophora. Results revealed that the range of Concentration of dominance (C) 0.04-0.06, Index of Diversity (H) 2.55-3.58, Richness index (R) 3.47-7.78 and Evenness Index (E) 0.84-0.93 was for trees and range of Concentration of dominance (C) 0.03-0.04, Index of Diversity (H) 3.37-3.86, Richness index (R) 6.22-6.12 and Evenness Index (E) 0.91-0.93 for shrubs at different elevation in Chandi beat. There were three woody plant species found as threatened category plant according to CAMP, 2013 i.e., Pleurolobus gangeticus, Oroxylum indicum and Zanthoxylum armatum which require conservation efforts suggested except Zanthoxylum armatum which has shown a good population in nature. Phytosocial and floristic diversity study on woody plants was not done before in this sanctuary so it will provide baseline information on the biodiversity status of the woody vegetation of the sanctuary and encourage conservation efforts, sustainable utilization of resources, and bio-perspective.