Browsing by Author "Venkatesh, D"
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Item Cardio-vascular changes during graded exercise.(1988-10-01) Venkatesh, D; Putturaya, K P; Sreekantha, C AIn the present study cardio-vascular adaptation to graded exercise was studied in untrained male medical students. The subjects were given two grades of exercise each lasting for about five minutes with a rest of fifteen minutes in between on a mechanically braked bicycle ergometer. There was a statistically significant rise in the heart rate during both the exercise sessions. This rise was persistent even after fifteen minutes of rest following the second session. The systolic blood pressure also showed a statistically significant rise in both the sessions. However, the diastolic blood pressure showed a significant drop in the second exercise session. Both these changes could possibly be attributed to sustained release of epinephrine.Item Estimation of salivary glucose level and plasma glucose level in subjects with and without diabetes mellitus: a comparative study.(2013-05) Jha, S K; David, C M; Saluja, I P; Venkatesh, D; Chaudhary, S UObjective: The objective of this study was to estimate and correlate salivary glucose levels and plasma glucose levels in non-diabetic subjects, controlled and uncontrolled diabetic subjects and to assess if salivary glucose can be a potentially useful non-invasive tool in diagnosing diabetes mellitus and in monitoring of glycemic control in diabetic patients. Materials and methods: A total of 90 subjects aged between 40-60 years participated in the study. Diabetic status was determined by estimation of random non-fasting plasma glucose levels and Glycosylated haemoglobin levels. Both unstimulated and stimulated saliva were collected and investigated for glucose levels. Salivary glucose levels were measured using the glucose oxidase method. Results: Salivary glucose levels were significantly higher in diabetics than non-diabetics. Mean un-stimulated salivary glucose level was 1.15 mg/dL in control group, 2.04 mg/dL in controlled diabetic group and 3.99 mg/dL in un-controlled diabetic group. There was a significant positive correlation between salivary and plasma glucose levels. Conclusion: These results show that salivary glucose concentration can be used as a potentially useful non-invasive tool for diagnosing diabetes mellitus and monitoring glycemic control in diabetic patients.Item Gender differences in predator induced pain perception in rats.(2003-03-23) Sudhakar, H H; Venkatesh, DPain is an unpleasant sensation. It warns the living being about the impending damage to the tissues. The perception of pain is influenced by physical and psychological factors. The impact of chronic intermittent psychological stress on pain perception and the differences in antinociceptive responses have been studied in male and anestrous female albino rats. Fifteen rats in each group were subjected to psychological stress, by exposing them to their natural predator--cat, for a duration of 20 min daily for 12 consecutive days. Tail flick response latency to radiant heat was used as a measure to evaluate pain perception. It was observed that both the groups had a relatively high pain threshold at the beginning of exposure schedule due to the modulation of opioid analgesic system by the higher level of circulating testosterone in males and low level of estrogen in anaestrous females. However, the threshold for pain perception showed a gradually declining trend in both the groups over the next 11 days to reach the control values. This increase in sensitivity to pain or decreased pain threshold could be attributed to the phenomenon of habituation.Item Impact of psychological stress, gender and colour on visual response latency.(2002-07-05) Venkatesh, D; Ramachandra, D L; Baboo, N Suresh; Rajan, B KThe measure of visual reaction time has been used to evaluate the processing speed of Central Nervous System and the co-ordination between the sensory and motor systems. As the reaction time is influenced by different factors, the impact of psychological stress, gender effect and the colour of objects in modulating the reaction time have been investigated in this study. 32 male and 38 female medical students in the age group of 18-21 yrs participated as subjects. It was observed that a) the males had a visual reaction time lesser than their female counterparts b) response latency for green colour was lesser than that for red in both the males and the female subjects and c) psychological stress resulted in a significant decline in the reaction time to green colour in males. The longer reaction time in females could be due to the effect of female sex hormones, which reduced the velocity of nerve impulse and increased the synaptic delay. Green colour evoked a faster response due to its stronger stimulation on the visual receptors.Item Non-secretor status; a predisposing factor for vaginal candidiasis.(2004-04-04) Kulkarni, Dayaprasad G; Venkatesh, DA secretor is an individual who secretes blood group antigens into body fluids such as saliva, sweat, tears, semen and serum. An attempt has been made to establish the correlation between the secretor status and susceptibility to vaginal candidiasis. The secretor status was determined by haemagglutination inhibition technique. The presence of Candida albicans infection was detected by direct microscopy of the wet smear and confirmed by germ tube test and corn meal agar test. It was observed that out of the 64 patients, 15 were secretors and 49 were non-secretors. However 43 subjects were secretors and 13 non-secretors among the 56 controls. Thus prevalence of vaginal candidiasis was significantly higher in non-secretor group (P<0.01). The absence of blood group antigens in the body fluids and the lack of enzyme glycosyl transferase enhance the attachment of yeast to the epithelial cell and render the non-secretor more prone to infection.Item Predator induced stress and its analgesic potential on estrous and anestrus albino rats.(2001-04-02) Sudhakar, H H; Venkatesh, DIt has been established that physical stress induces antinociceptive effect. In the present study efforts were made to investigate the role of chronic intermittent psychological stress in the induction of the analgesic effect and the probable role of estrous cycle in modulating the antinociceptive response. Albino rats in regular estrous cycle (n = 15) and those in anestrus (n = 15) were exposed to psychological stress for a period of 20 min each day for 12 consecutive days. The predator (domestic cat) was used to induce the psychological stress. At the end of each session tail flick response time to heat was recorded as a measure of pain perception. It was observed that female estrous rats had a low pain threshold in the beginning but its tolerance increased gradually reaching a peak by 6th to 7th day and returned to control level by 11th day. The anestrus female had higher pain threshold at the beginning and showed a gradual decline to reach the control level as estrous females by 12th day. These results suggest that the ovarian hormones and the corticosterone may modulate the impact of stressor on endogenous pain inhibition and other stress responsive systems.