Browsing by Author "Upadhyay, Ratna"

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    Anti-ageing effects of CollabZen™ in healthy human volunteers: a randomized, double blind, placebo-controlled study
    (2024-06) Gadani, Mihir C.; Badak, Sneha; Upadhyay, Ratna
    Background: There are several concerns related to combating signs of ageing. Considering the long-term safety concerns of cosmetic formulations, a safe and effective approach using nutritional supplements and naturals should be of great help. CollabZenTMis one such a blend of three plant materials known as Phyllanthus emblica, Camellia sinensis, and Coffea arabica,earlier tested for collagen building in human cells in-vitro. The current study aims to explore its potential as a nutraceutical product for skin ageing.Methods:The study enrolled 64 volunteers both genders (mean age=45.75) with crow's feet wrinkles. One group (n=32) received a placebo capsule (Product A) and other group received CollabZenTMcapsules (Product B). Dermatological parameters were assessed at 0thday, 4thand 8thweek, and self-assessment questionnaires for efficacy and tolerance were collected on 4thand 8thweek. The trial is registered at https://ctri.nic.in/, CTRI/2022/10/046168.Results:The results showed that product B (CollabZenTM) was significantly effective than the placebo in improving deep skin hydration on the face (p=0.009), increasing facial skin elasticity (p=0.001), and enhancing firmness (p=0.001) after 8 weeks. Participants in Group B reported higher levels of satisfaction regarding their perceived skin health compared to group A based on self-assessment at the 8thweeks (p<0.01). Moreover, only one volunteer in each group experienced mild intolerance at the end of 8th week, demonstrating the safety of these nutraceutical ingredients and excipients.Conclusions:CollabZenTM, with its known antioxidant and collagen-boosting properties and current findings can be considered a valuable nutraceutical product for the anti-ageing sector of the cosmetic industryCollabZenTM
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    In vitro anti-estrogenic potential of FertiZen-R™- a nutraceutical ingredient for estrogen modulation
    (Medip Academy, 2023-03) Gadani, Mihir; Upadhyay, Ratna; Raut, Supriya; Badak, Sneha
    Background: According to CDC, polycystic ovarian syndrome (PCOS) is responsible for infertility in women with 6-12% incidences all over the world. The current treatment options available have several side effects such as amenorrhea and obesity amongst others. Dietary interventions such as non-estrogenic and androgen-suppressing foods along with nutraceutical products is considered for treating PCOS with minimum side effects. One such product of Zenherbs lab called FertiZen-R™ is a combination of three phytochemicals from three plants viz., Foeniculum vulgare, Linum Usitatissimum, Glycyrrhiza glabra, hibiscus extract and is developed as a product to treat and control PCOS.Methods: The FertiZen-R™ was quantified for the presence of phytochemicals such as glycyrrhizic acid, polyphenols, and saponins. It was further tested for estrogenic/anti-estrogenic potential on estrogen-positive breast cancer cell line (MCF-7) using an E-Screen assay.Results: The FertiZen-R™ showed presence of 5% glycyrrhizinic acid, 5% saponins, and 2-3% polyphenols. It exhibited a strong anti-estrogenic potential with 40-50% inhibition from concentrations as low as 0.156 mg/ml like tamoxifen (IC50 at 0.156 mg/ml), while inositol, a natural growth promoter, showed no effect on the cell viability.Conclusions: FertiZen-R™ showed anti-estrogenic potential when tested in-vitro and can be used to treat PCOS in women even with ER-positive breast cancer cells. However, clinical studies to determine the dosage are required to warrant the potential of FertiZen-R™.
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    A prospective, randomized double-blind, placebo-controlled study for safety and efficacy of SesZen-Bio™: a proprietary Sesbania grandiflora extract in managing hair and scalp health in healthy adults
    (2024-06) Upadhyay, Ratna; Gadani, Mihir C.; Badak, Sneha; Patel, Nayan; Merja, Apeksha; Patel, Maheshvari
    Background:Hair loss, a common multifactorial condition affecting both genders, results from causes like extrinsic factors (pollution, sun, humidity, and temperature), nutritional variation, or intrinsic factors such as ageing, heredity, hormonal and medical conditions. Some of the damages caused by these factors can be effectively managed with multivitamins, minerals, antioxidant natural products. Present study assessed use of standardised herbal Sesbania grandifloraextract for improving hair density, hair thicknessand scalp health along with a serum biomarker to establish the probable mechanism of action.Methods:The study was approved by the ethics committee and was conducted as per standard national regulations. 51 randomized subjects (mean age: 39.40±5.80 years) received either test-treatment or placebo for consecutive 56 days. Instrumental assessments included a phototrichogram to assess hair density, thickness, and scalp condition.Results:SesZen-BioTMwhich is derived from Sesbania grandifloraextracts showed an improvement in hair density, hair thickness and ferritinin 8 weeks of usage suggesting it stimulates the keratin production which resulted in improved follicle growth. By day 56 of usage, hair density and thickness improved by 58.92±28.69 cm2and 3.68±2.69 ?m respectively from baseline (both p<0.0001) in the treatment group.This indicates towards 25% improvement in hair density,16.94%in hair thickness and almost 72% volunteers indicated an improvement in hair healthalong with 27% increase in serum ferritin. Conclusions: Sesbania grandifloraextract -SesZen-Bio®showed beneficial nutritional effects on research subjects, proving its usefulness as a well-tolerated and efficient daily supplement to improve hair health.