Browsing by Author "Ticku, M K"
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Item N-methyl-D-aspartate (NMDA) receptor: friend or foe?(1998-10-05) Robichon, R; Ticku, M KItem Pharmacological effects of Withania somnifera root extract on GABAA receptor complex.(1991-08-01) Mehta, A K; Binkley, P; Gandhi, S S; Ticku, M KA methanolic extract of W. somnifera root inhibited the specific binding of [3H]GABA and [35S]TBPS, and enhanced the binding of [3H]flunitrazepam to their putative receptor sites. The extract (5 micrograms) inhibited [3H]GABA binding by 20 +/- 6 per cent whereas a concentration of 1 mg of the extract produced 100 per cent inhibition. The extract (5-100 micrograms) produced 20 +/- 4 to 91 +/- 16 per cent enhancement of [3H]flunitrazepam binding. In functional studies using 36Cl-influx assay in mammalian spinal cord neurons, W. somnifera root extract increased 36Cl-influx in the absence of GABA. This effect on 36Cl-influx was blocked by bicuculline and picrotoxin; and enhanced by diazepam. These results suggest that the W. somnifera extract contains an ingredient which has a GABA-mimetic activity.