Browsing by Author "Thomas, Issac"
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Item Glutathione and associated enzymes in toxic cataractogenesis-selenite model.(2006-10-05) Mathew, Joe Prasad; Joseph, Priya; Thomas, V C; Thomas, IssacGlutathione, gamma-glutamyl cysteine synthetase (gamma -GCS) and glutathione reductase (GSH-R) activity were determined biochemically in the lens during various stages after subcutaneous administration of sodium selenite in multiple low dosages and single high dosages. The GSH concentration and gamma-GCS and GSH-R activity declined progressively after the selenite administration. The changes observed were discussed in relation to the possible role of selenite interaction with GSH and the enzymes.