Browsing by Author "Tannirandorn, Yuen"
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Item Animals and ethics.(2005-02-21) Phaosavasdi, Sukhit; Thaneepanichskul, Surasak; Tannirandorn, Yuen; Thamkhantho, Manopchai; Pruksapong, Chumsak; Kanjanapitak, Aurchart; Leong, HughItem Cell therapy: hype or hope.(2006-04-16) Kiatpongsan, Sorapop; Pruksananonda, Kamthorn; Tannirandorn, YuenCell therapy is a promising therapeutic tool for the next decade. It has a potential to cure a number of chronic diseases and conditions related to aging processes or degenerative changes. In addition, it could be used to replace cells and tissues in injured organs. Furthermore, it may provide a novel approach to congenital anomalies and genetic disorders where current therapeutic options are limited However, many crucial questions need answers to ensure a safe, effective and successful solution in the field of cell therapy. In Thailand, innovative knowledge and expertise in stem cell biology and technology are required as the key elements to make cell therapy a "real" hope.Item A comparative study of early postoperative feeding versus conventional feeding for patients undergoing cesarean section; a randomized controlled trial.(2006-10-30) Chantarasorn, Varisara; Tannirandorn, YuenOBJECTIVE: To compare the efficacy and side effects of early postoperative feeding versus conventional feeding for patients undergoing cesarean section. MATERIAL AND METHOD: Women undertaking uncomplicated cesarean section under regional anesthesia were randomly assigned to early feeding or conventional feeding groups. Early-fed women were offered a liquid diet within 8 hours after surgery, advanced to a soft diet on the next meal and then a regular diet. Conventional-fed women were prohibited from mouth-fed for the first 24 hours after surgery, advanced to a liquid diet on the first postoperative day, and then a soft diet on the second postoperative day. RESULTS: Two hundred patients were enrolled in the study; 107 patients were assigned to the early feeding group and 93 patients to the conventional feeding group. There were no significant differences in the demographic data between the two groups. In all cases, consistent anesthetic method was applied with no intraoperative adhesion and no post operative complications were observed. The rate of mild ileus symptoms in the early feeding group was significantly less than the conventional group (19.6% versus 31.1%, p = 0.03). The early feeding group also had significantly shorter time interval to bowel movement (16.7 hours versus 25.3 hours, p < 0.001), duration of intravenous fluid administration (20.5 hours versus 24.8 hours, p < 0.001), and overall length of hospital stays (3.3 days versus 4.0 days, p < 0.001). CONCLUSION: The study results indicated that the early feeding after uncomplicated cesarean section had reduced the rate of ileus symptoms and offer potential benefits associated with shorter interval to bowel movement, intravenous fluid administration, and length of hospital stays. However, management of postoperative feeding requires proper counseling on details of both regimens and flexibilities should be provided to accommodate early feeding when requested by the patients.Item A comparison of vaginal misoprostol 800 microg versus 400 microg for anembryonic pregnancy: a randomized comparative trial.(2005-10-28) Srikhao, Najnapa; Tannirandorn, YuenOBJECTIVE: To compare the efficacy, side effects and patient satisfaction between 800 microg versus 400 microg intravaginal misoprostol for anembryonic pregnancy. MATERIAL AND METHOD: Women who had diagnosed as anembryonic pregnancy were treated as IPD case and randomly assigned to receive either 800 microg or 400 microg intravaginal misoprostol. The second dose was administered in the equal dose if there was no evidence of abortion in 24 hr. The treatment failure was determined by no complete abortion within 48 hr. If spontaneous abortion had not occurred, or had heavy vaginal bleeding or evidence of incomplete abortion either by clinical manifestation or sonographic finding then dilatation and curettage was performed. RESULTS: Fifty patients were enrolled into the study, 25 patients were randomized to receive 800 mg and 25 patients were received 400 mg intravaginal misoprostol. Complete abortion within 48 hr was not different between the 2 groups (72%). However complete abortion within 12 hr was significantly higher in the 800 mg group than in the 400 mg group (64% versus 20%, respectively, p = 0.016). The median time to abortion in the 800 mg group was significantly shorter than in the 400 mg group (9.0 hr versus 16.0 hr, respectively, p = 0.01). There was no significant difference in the side effects and patients' satisfaction between both groups. CONCLUSION: Vaginal misoprostol can be used for termination of pregnancy in case of anembryonic pregnancy with high successful rate of complete abortion and no serious adverse effects. We recommend the 800 microg vaginal misoprostol regimen because within 12 hr the complete abortion rate was higher and the median time to abortion was shorter than the 400 microg regimen with no difference in side effects. This may decrease the suffering time of both physical and psychological trauma to the patient before complete abortion has occurred.Item Conventional and novel methods for embryonic stem cell line derivation.(2006-06-21) Kiatpongsan, Sorapop; Tannirandorn, Yuen; Numchaisrikhabsc, Pranee; Rungsiwiwut, RuttachukCell therapy is the promising therapeutic tool for the next decade. "Regenerative Medicine" based on cell and tissue replacement therapy is proposed as a revolutionary approach to various chronic and incurable conditions. The first key step for successful cell therapy is the establishment of clinical grade human Embryonic Stem Cell (hESC) lines. This article provides a concise summary on conventional and novel methods for hESC line derivation. There is also discussion on progression, future direction and problems in hESC line development. In Thailand, more advance knowledge, skill, and technology are required to develop the first human embryonic stem cell line and step forward to make cell therapy a reality.Item Correlation of 4- and 24-hour urine protein in women with initially diagnosed hypertensive disorders in pregnancy.(2003-06-20) Wongkitisophon, Kitti; Phupong, Vorapong; Yamasmit, Waralak; Pansin, Pongsak; Tannirandorn, Yuen; Charoenvidhya, DhiraphongsOBJECTIVE: To determine whether 4-hour urine protein value correlates with 24-hour urine protein value in women with hypertensive disorders in pregnancy. STUDY DESIGN: Cross-sectional study was performed in 38 in-patient pregnant women who were initially diagnosed as having hypertensive disorders in pregnancy. Urine samples were collected within 24 hours in 2 successive periods: the first 4-hour and the next 20-hour urine, in separate containers. The urine volume, urine protein and creatinine concentrations were thus separately measured. The 4- and 24-hour urine proteins were calculated and the correlation between both groups was determined by simple linear regression analysis. RESULTS: A total of 38 patients were recruited into the study, 26 had mild preeclampsia, 5 had severe preeclampsia, and 7 had superimposed preeclampsia. The result of the 4-hour urine protein was found to correlate with those of the 24-hour urine protein for patients with hypertensive disorders in pregnancy (p < 0.001). CONCLUSION: Total protein values of 4-hour samples positively correlated with values of 24-hour samples of patients with hypertensive disorders in pregnancy. This might be modified and used for urine protein collection in outpatients to improve the compliance.Item Difficulties on ethics in medical practice.(2004-01-20) Phaosavasdi, Sukhit; Taneepanichskul, Surasak; Tannirandorn, Yuen; Uerpairojkit, Boonchai; Pruksapong, Chumsak; Karnchanapitak, AuarchartItem A disputable medical profession.(2004-09-02) Phaosavasdi, Sukhit; Taneepanichskul, Surasak; Tannirandorn, Yuen; Uerpairojkit, Boonchai; Pruksapong, Chumsak; Kanjanapitak, AurchartItem The effects of the new Thai drug bill.(2003-02-08) Phaosavasdi, Sukhit; Taneepanichskul, Surasak; Tannirandorn, Yuen; Karnjanapitak, Aurchart; Pruksapong, Chumsak; Kullavanijaya, PinitItem Embryonic stem cell bank.(2006-07-03) Kiatpongsan, Sorapop; Wacharaprechanont, Teera; Tannirandorn, YuenEmbryonic stem cell bank is a cornerstone for stem cell research. It is providing essential resources to support advances in research in this challenging field that promises broad-ranging cell and tissue therapy. It is important to make good quality and well characterized embryonic cell lines that will be available for both research and clinical purposes. This article provides a concise summary on embryonic stem cell banking processes from cell line characterization, storage, quality assurance, safety testing, distribution, and post-distribution monitoring. It also states the importance of an international network and collaboration for technology and knowledge transfer Moreover, the Bank should play a substantial role as a national reference and a training center for stem cell research.Item Ethical consideration for the senior physician.(2003-04-22) Pruksapong, Chumsak; Phaosavasdi, Sukhit; Taneepanichskul, Surasak; Tannirandorn, Yuen; Kullavanijaya, Pinit; Karnjanapitak, AurchartItem Ethics and laws.(2008-01-05) Phaosavasdi, Sukhit; Taneepanichskul, Surasak; Tannirandorn, Yuen; Phupong, Vorapong; Uerpairojkit, Boonchai; Pruksapongs, Chumsak; Kajanapitak, AurchartItem Ethics and policy.(2003-11-31) Phaosavasdi, Sukhit; Taneepanichskul, Surasak; Tannirandorn, Yuen; Pruksapong, Chumsak; Karnjanapitak, Aurchart; Kullavanijaya, PinitItem Ethics and the comprehensive application of epistemology in medical practice.(2005-12-08) Phaosavasdi, Sukhit; Taneepanichskul, Surasak; Tannirandorn, Yuen; Uerpairojkit, Boonchai; Thamkhantho, Manopchai; Pruksapong, Chumsak; Kanjanapitak, Aurchart; Phupong, VorapongOur simple definition of ethics is good thought, speak and action. Epistemology means the hypothesis of facts about thought, speech and action. Medical practice is all means of medicine. Medicine classifies people into normal and abnormal. The abnormal are the sick. They loose some organs or those normal looking organs are dysfunctional. They are social problems, some can be treated, and some do not get the appropriate care. The problems of society of normal people are overeating and obesity, abortion, drug abuse, promiscuity, torture, terrorism, disobeying rules and order, corruption, brain-washing and unethical advertisements, etc. On the other hand, the social problems of the abnormal are down, deafness, blindness, dumb, hypertension, hypercholesterolemia, diabetes mellitus and cancer, etc. An example of the social-doctor problem is the mal distribution of doctors in rural areas. It was reported by the ministry of public health that the ratio of doctor to population to be 1:800 in Bangkok and 1:5, 700 in some rural areas in the north eastern part of Thailand. The doctors, themselves, are at a high grade of worker and intelligent quotient. They know all the problem and, at the same time, create problems, both, faster than the general population can do. It affects good and bad in the society. In the past, present and the foreseeable future the medical students get their studies in the western style. Their medical schools are situated in big cities. These schools are old and famous. They learn their medical procedure in a big hospital of more than 400 beds in the inpatient department wards. Their instructors and professors are highly qualified, are middle class people and well accepted in the society. Their families are lovely and warm. Their children study in the first class schools in town. The medical students feel very happy and appreciate seeing their professors in television routinely at prime time. In conclusion, their professors are an example of role model for them to follow. Everyone looks for security in her/his profession. Facts need no proof and reference. People with justice in mind should believe and understand the above mentioned. This leads to the problem of mal distribution of doctors in rural areas, why do doctors live in big cities or wish to be in the private sector? In fact, not many a number of doctors serve in the rural area. About 4-5 of them, their name will be announced yearly as the best rural doctor award. After the big ceremony, lasted not longer than a month, it is hard to remember their name. They are proud to be praised, it pushes them into stress intentionally with all the best of their intelligence and the total of their body strength to work harder in rural. Unfortunately their earning, the security of their profession, the increased chance of being sued, to get caught in the medical litigation, the expenses of their family social status and the study of their children cannot be compared to of those doctors in big city and/or in the private sector. Mal distribution of doctors in remote rural areas has been a persisting unresolved problem in many parts of the world, why not apply the principles of ethics and epistemology? They have been left, untouched forever.Item Ethics and the drafting of the "National Health Insurance Bill".(2002-08-31) Phaosavasdi, Sukhit; Tannirandorn, Yuen; Kullavanijaya, Pinit; Taneepanichskul, Surasak; Karnjanapitak, AurchartItem Ethics in general practice.(2003-10-03) Phaosavasdi, Sukhit; Taneepanichskul, Surasak; Tannirandorn, Yuen; Pruksapong, Chumsak; Karnjanapitak, Aurchart; Kullavanijaya, PinitItem Ethics in the education system.(2003-06-22) Phaosavasdi, Sukhit; Taneepanichskul, Surasak; Tannirandorn, Yuen; Pruksapong, Chumsak; Kullavanijaya, PinitItem Ethics of clinical trials in human.(2002-12-08) Phaosavasdi, Sukhit; Taneepanichskul, Surasak; Tannirandorn, Yuen; Karnjanapitak, Aurchart; Pruksapong, Chumsak; Kullavanijaya, PinitItem Ethics of doctors during difficult period.(2003-01-08) Phaosavasdi, Sukhit; Taneepanichskul, Surasak; Tannirandorn, Yuen; Karnjanapitak, Aurchart; Pruksapong, Chumsak; Kullavanijaya, PinitItem The ethics of elderly physicians.(2003-05-16) Phaosavasdi, Sukhit; Taneepanichskul, Surasak; Tannirandorn, Yuen; Pruksapong, Chumsak; Kullavanijaya, Pinit; Karnjanapitak, Aurchart
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