Browsing by Author "Subhalakshmi, V"

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    Beyond Toothpaste: The Role of Intraoral Fluoride Devices in Oral Health Maintenance
    (People's University, 2024-12) Nagappan, JS; Dhanabalan, O; Subhalakshmi, V; Parthasarathi, S.
    Dental caries remains a significant concern, particularly among medically compromised individuals, those with mental disabilities, and the elderly. Fluoride has long been utilized as a preventive measure against dental caries through various modalities, including water fluoridation, systemic intake, and topical applications. Intraoral fluoride-releasing devices represent an innovative advancement in preventive dentistry, offering a targeted and sustained approach to reducing caries incidence. These devices provide controlled, long-term fluoride release directly into the oral cavity, ensuring optimal fluoride levels in saliva and dental plaque. This mechanism supports enamel remineralization, inhibits demineralization, and suppresses the activity of cariogenic bacteria. Diverse designs, such as fluoride- releasing elastomers, polymer-based systems, and bioadhesive materials, have demonstrated effectiveness in both clinical and experimental settings. This review examines the types and clinical applications of intraoral fluoride-releasing devices, emphasizing their role in caries prevention and potential directions for future research.
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    Immunohistochemical Expression of BCl2 Oncoprotein in Varying Histological Grades of Oral Squamous Cell Carcinoma.
    (Light House Polyclinic, 2025-03) Subhalakshmi, V; Jaiswal, R; Priyadharshini, IK; Ambika, M
    Oral cancer has been rising in alarming numbers in the world which is anticipated to escalate at 70% by 2030. Although a lot of factors are responsible for the disease, genetics, and gene mutations play a major role in uncontrolled proliferation. Another major factor is apoptosis which is programmed cell death. Apoptosis generally happens in two pathways Extrinsic pathway which involves trans-membrane receptor-mediated interaction and by Intrinsic pathway which is a mitochondrial-initiated event. There are Pro-apoptotic genes that support apoptosis like Caspases, TNF, and P53 families, and Anti-apoptotic genes like BCL-2 which stop the programmed cell death leading to cellular proliferation and tumor progression. This study was done to find the role of the anti-apoptotic protein BCL2 in varying histological grades of oral squamous cell carcinoma by immunohistochemistry.