Browsing by Author "Srivastava, Sakshi"

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    Comparative study on the efficacy of mifepristone versus mifepristone and misoprostol in the induction of labor in cases of intrauterine fetal demise
    (Medip Academy, 2024-03) Srivastava, Sakshi; Sarkar, Ruma; Bhadkaria, Shivani; Sharma, Pratima
    Background: This study aimed to compare the efficacy of two labor induction methods, mifepristone alone and mifepristone followed by misoprostol, in cases of intrauterine fetal demise (IUFD) beyond 28 weeks of gestation.Methods: A prospective study was carried out at, BRD Medical College in Gorakhpur and aimed to investigate the efficacy of two different methods for labor induction in pregnancies with intrauterine fetal demise (IUFD) beyond 28 weeks of gestation during September 2019 to August 2020. Sixty participants were divided into two groups of 30 each, with mifepristone administered orally in both groups. Group 2 received additional vaginal misoprostol. Patient demographics, Bishop scores, induction to active labor intervals, and induction to delivery intervals were examined. Augmentation methods, side effects, complications, and time to full dilatation were analyzed.Results: The groups exhibited similar patient characteristics, including age, parity, socioeconomic status, and literacy rates. Gestational age at induction and Bishop scores were comparable. Both groups showed substantial improvements in Bishop scores. The induction to active labor interval was shorter in the mifepristone group, and the induction to delivery interval was similar. The mifepristone group required fewer mifepristone tablets, while the combination group used less misoprostol, reducing side effects. Complications were minimal, with a decreased need for augmentation methods in both groups.Conclusions: Mifepristone, whether used alone or followed by misoprostol, proved effective in labor induction for IUFD beyond 28 weeks. Mifepristone's ability to enhance cervical ripening and prostaglandin sensitivity makes it a promising option for reducing the risks associated with delayed birth in cases of IUFD. These findings suggest that mifepristone can be a valuable addition to obstetric practices, particularly in cases where traditional induction methods may pose greater risks.
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    Dengue in India.
    (2012-09) Gupta, Nivedita; Srivastava, Sakshi; Jain, Amita; Chaturvedi, Umesh C
    Dengue virus belongs to family Flaviviridae, having four serotypes that spread by the bite of infected Aedes mosquitoes. It causes a wide spectrum of illness from mild asymptomatic illness to severe fatal dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS). Approximately 2.5 billion people live in dengue-risk regions with about 100 million new cases each year worldwide. The cumulative dengue diseases burden has attained an unprecedented proportion in recent times with sharp increase in the size of human population at risk. Dengue disease presents highly complex pathophysiological, economic and ecologic problems. In India, the first epidemic of clinical dengue-like illness was recorded in Madras (now Chennai) in 1780 and the first virologically proved epidemic of dengue fever (DF) occurred in Calcutta (now Kolkata) and Eastern Coast of India in 1963-1964. During the last 50 years a large number of physicians have treated and described dengue disease in India, but the scientific studies addressing various problems of dengue disease have been carried out at limited number of centres. Achievements of Indian scientists are considerable; however, a lot remain to be achieved for creating an impact. This paper briefly reviews the extent of work done by various groups of scientists in this country.
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    Role of Bacterial Vaginosis in Patients with Idiopathic Pre- Term Labour.
    (2016-03) Gupta, Ranjana; Premi, H K; Srivastava, Sakshi; Dahiya, Sonika; Chandra, Sarita
    Background: To find out the correlation of bacterial vaginosis (BV) in idiopathic preterm labour and find its association with an adverse pregnancy outcome in patients with idiopathic preterm labour. Methods: This is a comparative study, comprising of 150 pregnant females in study group admitted with preterm labour without any obvious cause and 150 pregnant women with singleton pregnancy at term in the control group. Both the groups were tested for BV by using Amsel's criteria and Nugent's criteria. Diagnosis of BV was stamped based on gram staining of vaginal discharge smear. All patients were followed till delivery. Results: In the study group, significantly large number of women tested positive for BV on gram staining of vaginal discharge as compared to control group (20.6% vs 8.0%). In the study group, an adverse pregnancy outcome in the form of preterm delivery (<37 weeks) was noted in 93.4% women testing positive for BV and only in 47.9% women testing negative for BV. The majority of women with BV +ve were more likely to deliver before or at 34 weeks (58.06%) compared to women with BV-ve (14.28%).Conclusion: BV was significantly associated with preterm labour and preterm delivery and adverse perinatal outcomes.
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    Study of demographic profile and causative factor in female infertility
    (Medip Academy, 2023-12) Bhadkaria, Shivani; Srivastava, Sakshi; Mishra, Kalpana; Vibha
    Background: Infertility is a global health concern affecting millions of couples worldwide, with a significant impact on physical health and societal disparities. This study investigates female infertility in a specific population in India.Methods: The study, conducted at Nehru Hospital, BRD Medical College, Gorakhpur during September 2019 to August 2020 involved 150 infertile couples seeking conception assistance. Demographic profiles, causative factors, and management approaches were explored. Data were collected through medical histories, physical examinations, and various investigations.Results: Of the infertile women, 57.33% experienced primary infertility, and 42.66% had secondary infertility, with the 26-30 age group being the most affected. A majority resided in rural areas (64.67%), followed Hinduism (87.33%), and 65.33% had at least a matriculation level of education. Most women were housewives (90%). Male partners exhibited addictive habits in 37.33% of cases. The study revealed the complexity of female infertility, with factors such as pelvic inflammatory disease, polycystic ovarian syndrome, myoma of the uterus, uterine anomalies, endometriosis, and tubal pathology playing crucial roles.Conclusions: This study provides valuable insights into the multifaceted nature of female infertility. It highlights the importance of tailored diagnosis and treatment approaches to address specific causes. The findings challenge assumptions about the correlation between demographic factors, such as religion, education, and occupation, and infertility outcomes. Male factors, particularly addictive habits, are also significant contributors to infertility. Further research is needed to gain a broader understanding of infertility factors in diverse populations.