Browsing by Author "Srivastava, R K"
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Item Alveolar stability of rat lung under simulated high altitude.(1976-07-01) Srivastava, R K; Sachan, A S; Sharma, S KItem Antisialogogue activity of some oral anticholinergic formulations.(1985-07-01) Srivastava, R K; Garg, K N; Agarwal, K KItem Aspirin in experimental cataractogenesis.(1984-12-01) Gupta, P P; Pandey, D N; Pandey, D J; Sharma, A L; Srivastava, R K; Mishra, S SItem Atropine propranolol interaction on pupil size and heart rate of conscious rabbits.(1984-03-01) Tripathi, K D; Srivastava, R K; Tayal, GItem Cardiac failure and arrhythmias in lymphocytic lymphoma-reversal by chemotherapy.(1982-01-01) Singhal, S S; Jain, P K; Srivastava, R KItem Cerebral palsy--an etiological study.(1992-11-01) Laisram, N; Srivastava, V K; Srivastava, R KFive hundred and forty four cases of cerebral palsy were studied to find the etiology. Male to female ratio was 1.9:1. Prenatal, natal and postnatal factors were found in 42 (7.72%), 238 (43.75%) and 142 (26.1%) cases respectively. Only 79 (14.52%) cases were found to have more than one factor which could have contributed to brain damage. In 43 (7.9%) cases the prenatal, natal and postnatal history were normal and the cause was not known. Toxemia (1.29%) cases and microcephaly (1.84%) cases were the most common etiological factors in the prenatal category. Among the natal causes, birth anoxia was the most common etiological factor and was observed in 24.45% cases. Infections of the central nervous system comprised the major etiopathogenetic factors of the postnatal causes--11.95% cases had encephalitis, while 5.15% cases had meningitis. In cases where more than one etiology was present, the most frequent causes were a combination of prematurity or birth anoxia in association with toxemia, antepartum hemorrhage, prolonged labour, twins, forceps or caesarean delivery. Anoxia was consistently the most common etiological factor in those cases of monoplegia paraplegia, quadriplegia, diplegia, and ataxia, i.e. in 0.55%, 1.29%, 11.76%, 6.07% and 0.55% cases respectively. The present study reveals that majority of the cases were found to have natal or post natal etiology.Item Cerebral palsy.(1992-08-01) Srivastava, V K; Laisram, N; Srivastava, R KThe clinical pattern and etiology of 544 cases of cerebral palsy were studied retrospectively. Of these cases, 354 (65.1%) were males. Four hundred and ninety seven (91.4%) cases were of spastic type. Hypotonic, ataxic and athetoid cerebral palsy were observed in 5.5, 1.5 and 1.3% cases, respectively. There was one case each of tremor and mixed type. In the spastic group, quadriplegia comprised the maximum number of cases (34.9%). Hemiplegia (28.7%) and diplegia (21.9) were also common. Mental retardation was found in 47.2%, while speech impairment was observed in 37% cases. Other handicaps included visual (9%), seizures (8.8%), and auditory handicap (2.9%). The etiological factors were prenatal in 7.7% cases, natal in 43.8% cases and postnatal in 26.1% cases. More than one etiological factor was observed in 14.5% cases, while in 7.9% cases, no apparent cause could be found.Item Characterisation of adrenoceptors mediating leucocytosis in rabbits.(1985-06-01) Srivastava, V K; Agarwal, A K; Srivastava, R K; Jaju, B PItem Characterization of mycobacteria isolated from bovines by PRA-targetting hsp 65 gene region.(2006-03-22) Parashar, Deepti; Srivastava, R K; Chauhan, D S; Sharma, V D; Singh, Mradula; Lavania, Mallika; Chauhan, Aradhana; Bhatia, A K; Katoch, V MBovine tuberculosis caused by the bacterium Mycobacterium bovis is a major infectious disease of animals and has zoonotic importance for humans. Even though the incidence is believed to be very low in India, human tuberculosis caused by M. bovis has been increasingly recognized in many other countries of the world. As differentiation of mycobacterial species take long time, a method for the rapid identification of mycobacteria isolated from bovine samples to the species level was used, which is based on polymerase chain reaction (PCR) of the gene encoding for the 65-kD protein followed by restriction analysis. The method involves restriction enzyme analysis of PCR products obtained with primers common to all mycobacteria and generate M. tuberculosis complex specific pattern. PRA was performed on 33 bovine isolates of which 90.9% (30/33) isolates were identified clearly as M. tuberculosis complex, M. fortuitum, M. phlei and M. smegmatis using restriction enzyme Hae III.Item Clofibrate, fibrinolysis and experimental myocardial damage.(1981-01-01) Saxena, K K; Gupta, B; Srivastava, R K; Singh, R C; Prasad, D NItem Coronary occlusion in the dog & pig: its effect on fibrinolysis & coagulation.(1981-06-01) Saxena, K K; Tayal, G; Kapoor, S C; Gupta, B; Srivastava, R K; Prasad, D NItem Differential modulation of nociceptive responses to mu and kappa opioid receptor directed drugs by blood glucose in experimentally induced diabetes rats.(2000-03-06) Tandon, M; Srivastava, R K; Nagpal, R K; Khosla, P; Singh, JThe study has evaluated the effect of diabetes associated hyperglycaemia on nociception and antinociception induced by morphine, buprenorphine and pentazocine in female albino rats. Rats were allocated into 3 groups of 20 each--group I consisted of control having normal blood glucose levels (BGLs), group II consisted of streptozotocin-induced diabetics (STZ-D) having hyperglycaemia and group III consisted of diabetic rats controlled with insulin treatment. Immediately before and 15, 30 min, 1, 2 and 3 hr after injection with test drugs, rats were subjected to a thermal noxious stimulus using tail withdrawal from hot water and tail-flick latencies (TFL) so generated were recorded. Similarly, before and 30, 45 min and 1 hr after injection with drugs rats were subjected to abdominal writhing with hypertonic saline and number of writhes were counted per 90 sec. In STZ-D animals (BGLs 317.95 +/- 3.8 mg/dl) a decreased TFL with an increase in the number of writhes compared to control and diabetes controlled with insulin treatment was observed. Percent maximum possible effect of morphine (5 mg/kg, s.c.) and buprenorphine (2 mg/kg, s.c.) was significantly lower when compared to control as well as STZ-D controlled with insulin treatment groups. Similarly percent protection from writhing of morphine (0.05 mg/kg, s.c.) and buprenorphine (0.01 mg/kg, s.c.) was significantly less in comparison to control and STZ-D controlled with insulin treatment group. However, percent maximum possible effect of pentazocine (20 mg/kg, s.c.) and percent protection from writhing of pentazocine (1 mg/kg, s.c.) was significantly high in STZ-D rats when compared to control and STZ-D rats controlled with insulin treatment groups. The results suggest that both mu and kappa--opioid receptors may be modulated by blood glucose levels possibly involving cellular energetics mediated change in potassium (KATP) channels in females rats, albeit differentially.Item Effect of 5-fluorouracil on rat bone marrow.(1984-07-01) Tewari, S P; Srivastava, R K; Verma, P; Zaidi, S HItem Effect of exercise on dyspnoea in rats inhaling sublethal concentration of methyl isocyanate (MIC).(1988-06-01) Srivastava, R K; Pant, S C; Vijayaraghavan, R; Kumar, P; Sachan, A S; Kaushik, M PItem Effect of garlic pretreatment on isoprenaline-induced myocardial necrosis in albino rats.(1980-07-01) Saxena, K K; Gupta, B; Kulshrestha, V K; Srivastava, R K; Prasad, D NAlbino rats were pretreated orally for seven days with different doses of the essential oil and juice of garlic. These animals were challenged with isoprenaline (85 mg/kg, s.c.) on day six and seven to induce myocardial necrosis. The same rats were also subjected to swimming test before and after forty eight hr of first injection of isoprenaline. Pretreatment with essential oil (2.0 and 4.0 mg/kg) and juice (2.0 and 4.0 ml/kg) significantly protected the myocardium from isoprenaline-induced necrosis. These animals also exhibited better swimming performance. In separate group of animals, pretreatment with garlic juice (4.0 ml/kg) or essential oil (4.0 mg/kg) improved the chances of survival in isoprenaline-challenged animals.Item Effect of high altitude stress on lung compliance in rats.(1976-11-01) Srivastava, R K; Sachan, A S; Sharma, S KItem Effect of nitrendipine, nimodipine and nisoldipine on experimentally induced myocardial infarction in rats.(1995-06-01) Kaur, A H; Singh, J; Srivastava, R K; Mathur, S KCardiac necrosis was produced in rats by administering isoproterenol sulphate (85 mg/kg, sc for 4 days). The myocardial damage was proved by observing the elevated levels of serum aspartate aminotransferase, ++alanine aminotransferase and lactate dehydrogenase and the changes were confirmed by his topathology. Nitrendipine, nimodipine and nisoldipine (10 mg/kg, ip) significantly reduced the elevated levels of these enzymes. The average degree of cardiac necrosis in these rats when observed microscopically and histologically was also found to be significantly reduced on pretreatment with these drugs. Nisoldipine was more effective in preventing cardiac necrosis as compared to nitrendipine and nimodipine.Item Effects of inhaled sublethal concentration of methyl isocyanate on lung mechanics in rats.(1987-08-01) Srivastava, R K; Vijayaraghavan, R; Kumar, P; Pant, S C; Sharma, S K; Sachan, A S; Kaushik, M PItem Efforts to improve nutritional status in rural areas of Gujarat, India.(2003-07-21) Bansal, R K; Srivastava, R K; Sharma, VItem Enhancement of insulin hypoglycaemia by beta adrenoceptor antagonists.(1978-01-01) Singh, R C; Srivastava, V K; Tayal, G; Srivastava, R K; Prasad, D NInteraction of insulin with beta-adrenoceptor antagonists was studied in conscious rabbits. Propranolol and metoprolol did not modify the peak of insulin hypoglycaemia but delayed its recovery. Practolol, sotalol and 1-INPEA enhanced the peak effect and delayed the recovery of insulin-induced hypoglycaemia. H 35/25 and d-INPEA did not modify insulin hypoglycaemia. The beta-blockers did not produce significant hypoglycaemia per se. Since sotalol, 1-INPEA (specific beta-adrenoceptor antagonists devoid of local anaesthetic activity); practolol and metoprolol (selective cardiac beta-1 adrenoceptor antagonists) enhanced hypoglycaemic action of insulin and H 35/25 (a selective beta-2 adrenoceptor antagonist) failed to affect it, it seems that selective beta-adrenoceptor blockade (similar to cardiac beta-1 adrenoceptors) mediates enhancement of insulin hypoglycaemia. Caution should, therefore, be exercised in administering beta-adrenoceptor antagonists and insulin together. A reduction in the dose of insulin may be necessary.
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