Browsing by Author "Srinivasan, K."
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Item Analytical Method Development For Simultaneous Determination Of Ubidecarenone And Vitamin E Acetate In Capsule Dosage Form By Hplc(Innovare Academic Sciences Pvt. Ltd., 2019-01) Grace, A. C.; Prabha, T.; Jagadeeswaran, M.; Srinivasan, K.; Sivakumar, T.Objective: To develop and validate a new simple, accurate, precise and sensitive high performance liquid chromatographic method (HPLC) method for simultaneous estimation of ubidecarenone and vitamin E acetate in capsule dosage form as per international conference on harmonization (ICH) guidelines. Methods: The chromatographic separation of drugs were achieved using hypersil C8 column (250 mm x 4.6 mm, 5µ) in isocratic elution mode with a mobile phase of methanol: ethanol: n-hexane (80:10:10 v/v/v) at a flow rate of 1 ml/min with ultra-violet (UV) detection at 210 nm. Results: The optimized method produced sharp peaks with good resolution, minimum tailing factor and satisfactory retention time were found to be 5.745 min and 12.565 min for vitamin E acetate and ubidecarenone respectively. The method was linear in the range of 60-180 µg/ml for ubidecarenone and 20-60 µg/ml for vitamin E acetate with a correlation coefficient of 0.999 and 0.9993 respectively. Mean recoveries observed for ubidecarenone and vitamin E acetate were 99.85% and 99.73% respectively. The percentage relative standard deviation (% RSD) of peak area for system precision, method precision, and intermediate precision were found to be less than 0.37%. The lower degree of % RSD obtained has proved that the method was precise and robust. Conclusion: A new simple HPLC method was developed and validated as per ICH guidelines for the simultaneous estimation of ubidecarenone and vitamin E acetate and the method can be effectively applied for the routine analysis of active pharmaceutical ingredient (API) and formulations.Item A comparative study to assess drinking expectancy and functioning in alcohol dependent patients with and without co-morbid depression(Medip Academy, 2020-08) Mani, Anu Mary; Srinivasan, K.; Sreedaran, PriyaBackground: Alcohol dependence syndrome (ADS) and major depressive disorder are highly prevalent. Much less is known about the expectancy of alcohol use in depressed patients with ADS. Few studies had compared the expectancy of alcohol use in ADS patients with and without co-morbid depression. Assessing the above factors may help to formulate effective prevention strategies. This study was designed to assess the difference in expectancy of alcohol use and functioning in patients with ADS with and without co-morbid depression.Methods: The difference in expectancy of alcohol use in 96 alcohol dependent patients, of which 24 had co-morbid depression and 72 without co-morbid depression was studied using drinking expectancy questionnaire. In addition, we compared the difference in functioning between the two groups using GAF.Results: Prevalence of depression in alcohol dependent patients was 25%. ADS patients with co-morbid depression had less expectancy about alcohol use for sexual enhancement and had lower level of functioning compared to ADS patients without depression.Conclusions: Less expectancy on sexual enhancement in patients with ADS and co-morbid depression could be possibly due to reduced libido in depressed patients. The observed lower functioning in ADS patients with co-morbid depression despite no difference in severity of alcohol use may be possibly explained by the added burden of both the diseases.Item A Cross Sectional, Analytical Study of the Morbidity Pattern among Boys Residing in Social Welfare Hostels in Tirupati Town, A. P..(Akshantala Enterprises Private Limited, 2020-02) Naik, Karamthoti Ravi; Srinivasan, K.; Prameela, B.; Prabhu, G. Ravi; Reddy, K. Ashok KumarThe role of hostels in the educational advancement of backward classes is long recognized. In closed homes like hostels, the morbid conditions especially infectious diseases like skin diseases and respiratory diseases tend to rapidly spread among others and become difficult to control. There is increased nutritional demand in this age group because of pubertal changes. It has been found that several school children especially from socially backward sections of the community suffer from nutritional health problems as well as other physical health problems. We wanted to evaluate the morbidity pattern among boys residing in social welfare hostels.METHODSThis is a cross sectional, analytical study to determine the morbidity pattern among boys residing in social welfare hostels. This present study was conducted from August 2013 to July 2014 among boys residing in three welfare hostels, one each for scheduled castes, scheduled tribes and backward classes in Tirupati town.RESULTSThe common prevalent morbid conditions found were skin disorders (46.4%), nutritional disorders (43.1%), eye diseases (29.0%), respiratory diseases (15.3%) gastrointestinal diseases (13.6%), ENT diseases (9.5%,), musculoskeletal conditions (1.0%), and other diseases (5.7%).CONCLUSIONSHealth education and increasing the nutritional supplements improve the health of children with regard to personal hygiene and common diseases. Provision of necessary materials like soaps, oils etc., under supervision of hostel staff will go a long way in controlling these infections.Item Pattern of alcohol use and drinking antecedents in alcohol dependent patients with and without co-morbid depression: a comparative study(Medip Academy, 2020-08) Mani, Anu Mary; Srinivasan, K.; Sreedaran, PriyaBackground: Few studies have compared the pattern of alcohol use in Alcohol dependence syndrome (ADS) patients with and without co-morbid depression. Assessing the pattern may throw light into prevention of relapses more effectively in alcohol dependent patients with co-morbid depression. This study was undertaken to assess the difference in pattern of drinking of alcohol in patients with alcohol dependence with and without co-morbid depression.Methods: A descriptive comparative study was designed to compare the difference in pattern of alcohol use in alcohol dependent patients with co-morbid depression and without co-morbid depression. Severity of dependence on alcohol was assessed using Alcohol Use Disorders Identification Test (AUDIT). Drinking pattern was assessed using Timeline Follow back Calender and Drinking Pattern Questionnaire. The data were statistically analysed.Results: Total 96 alcohol dependent patients (24 had co-morbid depression and 72 without co-morbid depression) were included in the study. There were no significant differences in alcohol use in both the groups in terms of AUDIT scores, amount of drinking, abstinence days or binge drinking. More frequent drinking was observed in circumstances related to emotional, physiological, financial and children related situations in patients with co-morbid depression (p<0.05).Conclusions: Drinking circumstances like emotional, physiological, financial and children related situations require more attention while assessing, treating and aiming at relapse of prevention in ADS patients with co-morbid depression.