Browsing by Author "Srimal, R C"
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Item 1,3-Bistertiary-aminomethyl pyrrocolines, a new class of hypotensive agents.(1976-01-01) Singh, G B; Gupta, C M; Nityanand, S; Srimal, R C; Nand, N; Dhawan, B NItem Acute toxicity & pharmacology of Centchroman.(1977-12-01) Chak, I M; Dua, P R; Kar, K; Srimal, R C; Dhawan, B NItem Adaptogenic activity of Indian Panax pseudoginseng.(1989-07-01) Dua, P R; Shanker, G; Srimal, R C; Saxena, K C; Saxena, R P; Puri, A; Dhawan, B N; Shukla, Y N; Thakur, R S; Husain, AThe crude extract and saponins of Indian pseudoginseng and saponins of Korean ginseng have been studied using a battery of biological tests in rats and mice. Indian pseudoginseng saponins were found to exhibit better activity than the Korean ginseng saponins in several tests employed. The results indicate a need for in-depth study of Indian pseudoginseng as an adaptogenic agent, after cultivation of the plant under controlled conditions.Item Alteration in systemic hemodynamics & regional brain blood flow by isoprenaline.(1988-09-01) Gulati, A; Srimal, R C; Dhawan, B NItem Anaesthetic technique of ketamine infusion: clinical and biochemical evaluation.(1982-04-01) Suri, Y V; Singh, D; Ansari, A A; Srimal, R CItem Anti-inflammatory and diuretic activity of a new class of compounds--Schiff bases of 3-amino-2-methylquinazolin 4(3H)-ones.(1995-04-01) Mishra, P; Gupta, P N; Shakya, A K; Shukla, R; Srimal, R CEighteen Schiff Bases of 3-amino-2-methylquinazolin-4(3H)-ones were synthesised and screened for anti-inflammatory and diuretic activity. Anti-inflammatory activity was identified in PNG-1, PNG-13, PNG-14, PNG-15 and PNG-17.Item Antiallergic activity of alkyl substituted pyrazolo[3, 4-d]pyrimidine (compound 88-765).(1995-01-01) Gupta, P P; Srimal, R C; Avasthi, K; Garg, N; Chandra, T; Bhakuni, D SCompound 88-765 (4-amino-6-methylthio-1-(2', 2'-diethoxyethyl)-1 H-pyrazolo[3, 4-d]pyrimidine) has shown potent antiallergic activity in experimental models. The compound inhibited the passive cutaneous anaphylaxis (PCA) reaction in rats in dose-dependent manner (5-100 mg/kg, po) by 47 to 87%. In mice it inhibited PCA by 78% at 50 mg/kg, po. It also inhibited mast cell degranulation of normal and passively sensitised rats induced by compound 48/80 and egg albumin, respectively. These effects of Compound 88-765 were comparable with that of disodium cromoglycate (DSCG). The results suggest that compound 88-765 possesses potent antiallergic activity.Item Antihistaminic activity of quinethindole: a 2-substituted pyrazinopyridoindole derivative.(1992-02-01) Patnaik, G K; Saxena, A K; Saxena, M; Srimal, R CQuinethindole, a 2-substituted pyrazinopyridoindole, showed specific antihistaminic (H1) activity in various in vivo and in vitro test models. It also inhibited antigen-induced contraction of ileum of sensitized guinea pig. The antihistaminic activity was of competitive nature.Item Bioactivity of marine organisms: Part VI--Screening of some marine flora from Indian coasts.(1992-06-01) Bhakuni, D S; Dhawan, B N; Garg, H S; Goel, A K; Mehrotra, B N; Srimal, R C; Srivastava, M NAlcoholic extracts of 50 botanically identified species of marine flora have been screened for a wide range of biological activities. Of these, 2 extracts exhibited anti-amoebic and antiviral activity each, 3 of them had anti-implantation activity; 9 had hypoglycaemic activity while hypotensive activity was associated with 11 extracts; 14 extracts were found to be diuretic and 1 of them had anti-inflammatory activity. Further, 10 of these extracts exhibited 2 types of activities while a combination of 3 and 4 types of activities was observed in one extract each. Follow-up studies have been carried out in some plants with confirmed activity. The active principles and results of these studies are reported.Item Bioactivity of marine organisms: Part VII--Effect of seaweed extract on central nervous system.(1994-06-01) Kamat, S Y; Wahidulla, S; D'Souza, L; Naik, C G; Ambiye, V; Bhakuni, D S; Jain, S; Goel, A K; Srimal, R CAlcohol extracts of marine algae (Rhodophyceae, Phaeophyceae and Chlorophyceae) were screened for their effect on central nervous system. Of 69 species investigated 8 appeared biologically active, 6 being CNS stimulant and two depressant, sites and dates of collection are given.Item Characterisation of dopamine receptors of central thermoregulatory mechanism in pigeons.(1980-03-01) Srimal, R C; Dhawan, B N; Dubey, M PItem Clinical pharmacology studies with Centchroman.(1977-12-01) Chandra, H; Srimal, R C; Kamboj, V P; Dhawan, B N; Gupta, N NItem Effect of anti-platelet therapy (aspirin + pentoxiphylline) on plasma lipids in patients of ischaemic stroke.(1993-04-01) Gaur, S P; Garg, R K; Kar, A M; Srimal, R CTwenty-one patients of ischaemic stroke were put on prolonged administration of antiplatelet drugs (aspirin 320 mg once daily with pentoxiphylline 400 mg thrice daily). The serum lipids along with other biochemical parameters were estimated before starting the treatment and after completion of 2 months of therapy. No significant changes were observed in any of the biochemical parameters including lipid profile except in serum high density lipoprotein (HDL) which increased significantly (< 0.05) after 2 months therapy. It is concluded that 2 months antiplatelet therapy has no adverse metabolic effect in patients of ischaemic stroke and the raised serum HDL may contribute to cerebral protective effect.Item Effect of centbucridine & lignocaine on biochemical changes in isoproterenol induced ischemia in rats.(1991-08-01) Dikshit, M; Srimal, R CEffect of lignocaine and centbucridine against isoproterenol-induced biochemical changes was studied in the rat. Isoproterenol (40 mg/kg twice) increased the heart weight, level of manolaldehyde (MDA) and activity of acid phosphatase, but decreased the myocardial phospholipid content at 48 h. In addition, increase in plasma triglyceride, cholesterol, MDA and creatine phosphokinase activity was observed. Pretreatment of the animals with lignocaine (10 mg/kg) or centbucridine (1, 3 and 10 mg/kg) protected the animals against these biochemical changes. However, increase in heart weight consequent to isoproterenol treatment could not be prevented. Total protection against creatine phosphokinase release in the blood was also not observed. The results suggest that the two drugs inhibit lipolysis. They may also inhibit phospholipases leading to protection against ischemia-induced changes in the rat.Item Effect of RO 15-1788 on diazepam, GABA & pentobarbitone induced EEG changes in rabbits.(1986-06-01) Singh, H K; Gulati, A; Srimal, R C; Dhawan, B NItem Effects of some antimicrobial agents on neuromuscular blocking activity of chandonium iodide.(1984-08-01) Suri, Y V; Singh, D; Mukherjee, K C; Raghubir, R; Srimal, R C; Dhawan, B NItem Evaluation of histamine H2 receptor blocking activity of a new 2-substituted pyrazinopyridoindole: diphenethindole.(1980-01-01) Patnaik, G K; Srimal, R C; Das, P K; Dhawan, B NItem Experimental evaluation of anti-inflammatory activity of 3,4-dimethoxyphenylethylamino-3-aminopyridine (Compound 64-92).(1973-05-01) Srimal, R C; Sharma, J N; Tangri, A N; Dhawan, B NItem Hypotensive activity of 1,3-disubstituted-1,2-propane diols & 1,3-distributed-2-hydroxy propylene diamines.(1981-11-01) Srimal, R C; Kansal, V K; Bhaduri, A PItem Modification of certain inflammation-induced biochemical changes by curcumin.(1985-02-01) Srivastava, R; Srimal, R C