Browsing by Author "Sood, Vikrant"

Now showing 1 - 5 of 5
  • Thumbnail Image
    Item
    Hepatitis A Virus-related Pediatric Liver Disease Burden and its Significance in the Indian Subcontinent
    (Indian Academy of Pediatrics, 2019-09) Sood, Vikrant; Lal, Bikrant Bihari; Gupta, Ekta; Khanna, Rajeev; Siloliya, Manish K; Alam, Seema
    Objectives: To study the Hepatitis A virus (HAV) infection-related pediatric liver diseaseburden. Methods: Hospitalrecords of 431 children (age <18 y) diagnosed to be sufferingfrom acute HAV infection during 2011 to 2018 were extracted and analyzed. Additionally, aseroprevalence study was done on 2599 participants (696 children and 1903 adults).Results: HAV infection accounted for about half (48.6% of acute hepatitis and 46.5% (92/198) of acute liver failure cases) of all acute onset icteric illness, with significant morbidity andmortality. As per seroprevalence data, 16.2% of children between 10-18 years of age, and10.3% of adults aged 18-30 years remained susceptible to HAV infection. Conclusion: HAVinfection is the major contributor the overall pediatric liver disease burden. A significantproportion of subjects remain susceptible to HAV infection even after 10 years of age.Population-based studies are required to further delineate the epidemiology of HAV infectionin India for deciding introduction of HAV vaccine in the national immunization schedule.
  • Thumbnail Image
    Item
    Outcome of Pediatric Living Donor Liver Transplantation in India
    (Indian Academy of Pediatrics, 2018-04) Sood, Vikrant; Alam, Seema
  • No Thumbnail Available
    Item
    Prevalence and clinicopathological Spectrum of Auto-Immune Liver Diseases & Overlap syndrome
    (Wolters Kluwer – Medknow, 2024-03) Varadarajan, Annapoorani; Rastogi, Archana; Maiwall, Rakhi; Bihari, Chhagan; Thomas, Sherin; Sood, Vikrant; Shasthry, Saggere Muralikrishna
    Aims: Autoimmune liver diseases (AILD) represent a spectrum of related yet distinct immune?mediated disorders. The literature on the prevalence of these AILDs in Indian population is scarce. This study aims to assess the prevalence and clinicopathological spectrum of various AILDs especially the overlap syndrome. Materials and Methods: A 10?year (2011–2020) cross?sectional, retrospective observational study of histological proven cases of AILD was conducted. Clinical, demographic, and laboratory parameters were retrieved. Two pathologists independently reviewed the liver biopsies and reassessed 18 histopathological parameters. Results: During the study period, 17664 liver biopsies were received, out of which 1060 (6%) biopsies of AILD were identified. After exclusion, we had 721 cases which revealed a distribution of autoimmune hepatitis (AIH)?64.7%, primary biliary cholangitis (PBC)?14.8%, primary sclerosing cholangitis (PSC)?7.6%, overlap AIH?PBC 11%, and overlap AIH?PSC 1.7%. AIH patients had significantly higher prevalence for severe lobular inflammation (27%, P ? 0.001), several lobular plasma cells (37%, P ? 0.001), central perivenulitis (30%, P ? 0.001), hepatic rosettes (51%, P ? 0.001), and necrosis (35.5%, P ? 0.001), while PBC patients had significantly higher frequency of florid duct lesions (11.2%, P ? 0.001), duct loss (83.17%, P ? 0.001), bile duct damage (76.6%, P ? 0.001), and periportal copper deposits (19.6%, P ? 0.001). Overlap AIH?PBC group had the highest proportion of severe portal inflammation (27.5%, P ? 0.001), prominent portal plasma cells (75%, P ? 0.001), moderate interface activity (53.7%, P ? 0.001), Mallory?Denk bodies (27.5%, P ? 0.001), and periportal cholate stasis (25%, P ? 0.001). Conclusion: Prevalence of biopsy?proven AILDs in our study cohort is 6%. AIH (64.7%) is the most common AILD followed by PBC (14.8%). Overlap syndrome (AIH?PBC) showed prevalence of 11%.
  • Thumbnail Image
    Item
    Study of Family Clustering and PNPLA3 Gene Polymorphism in Pediatric Non Alcoholic Fatty Liver Disease
    (Indian Academy of Pediatrics, 2018-07) Sood, Vikrant; Khanna, Rajeev; Rawat, Dinesh; Sharma, Shvetank; Alam, Seema; Sarin, Shiv Kumar
    Objectives: To find association of pediatric NAFLD with metabolicrisk factors, and Patatin-like phospholipase domain-containingprotein 3 (PNPLA3) gene polymorphism.Design: Cross-sectional studySetting: Pediatric Hepatology unit of a tertiary care hospitalParticipants: Overweight/obese children (<18 years) with (69patients) or without (30 patients) NAFLD (ultrasonographybased), and their parents.Intervention: Metabolic screening, PNPLA3 gene polymorphism,and transient elastographyOutcome measure: Association of pediatric NAFLD with parentalmetabolic risk factors and PNPLA3 gene polymorphism.Results: In the NAFLD group, there was high parental incidenceof metabolic diseases, fatty liver (80%) and low high-densitylipoproteins levels (84%). Family history of NAFLD (in any parent),higher alanine aminotransferase levels and higher totalcholesterol levels in the child independently predicted possibilityof NAFLD, but similar results could not be replicated for PNPLA3gene polymorphism. Controlled attenuation parametermeasurement (by transient elastography) had high sensitivity andspecificity to diagnose steatosis.Conclusion: There is high familial incidence of metabolicdiseases in children with NAFLD. Controlled attenuationparameter can be useful as a non-invasive modality to screen fattyliver in children.
  • Thumbnail Image
    Item
    Tetanus in Pediatric Patients - Predictors Affecting Mortality and Role of Immunoglobulin.
    (2011-12) Aggarwal, Mukul; Sood, Vikrant; Aggarwal, K C
    Analysis of pediatric tetanus cases was carried out to study the predictors of mortality and role of tetanus immunoglobulin (TIG). Shorter incubation period, onset time and autonomic dysfunction were significantly associated with mortality and may be used to stratify patients requiring intensive care. TIG may not have independent role in decreasing mortality in sick patients.