IMSEAR Repository :: Browsing by Author "Singh, Mamta"

Browsing by Author "Singh, Mamta"

Now showing 1 - 20 of 25

Allergic Conjunctivitis: A Practice Pattern Survey From North India
(World Wide Journals, 2019-11) Singh, Mamta; Sinha, Bibhuti Prassan
PURPOSE: The purpose of this survey was to establish the prevalence of AC and to know the practice pattern of managing ocular allergy in north India. METHODS: A descriptive cross sectional study done in the states of north India, involving registered practicing ophthalmologists (RP). The survey was conducted in the month of May 2019. 14 fourteen survey questionnaire prepared on significant clinical situations related to ocular allergy was sent via goggle form to 300 Ophthalmologists of north India. The response was recorded and analyzed. RESULTS: The survey was participated by 232 RP (77.33%) out of 300 whom the questionnaire was sent. The results analysis involved epidemiological, treatment and complication pattern. CONCLUSION:AC patients form a significant proportion of our clinical patients specially in summer season. The chronic nature of this disease specially VKC needs a judicious use of different pharmacological agents considering their adverse effects. Newer molecules like Alcaftadine, Bepotastine and various Immunomodulators need further study by randomized clinical trials for their relative efficacy as survey are not sufficient to give us a clear indication towards rationalized use.
Asymptomatic essential thrombocythemia: a case report.
(2003-10-18) Kapoor, Meenu; Misra, Vatsala; Singh, Mamta; Mehrotra, Ravi; Dwivedi, Manisha
Essential thrombocythemia (ET) is a clonal disorder of unknown etiology involving multipotent hematopoietic progenitor cell and belongs to the spectrum of chronic myeloproliferative disorders (CMPD). It is rarest of the CMPD with no case reported from India. The case being presented was detected incidentally during routine investigations in an adult female who presented with mild abdominal discomfort.
A Comparable Study on Efficacy of Granisetron and Promethazine in Controlling Hyperemesis Gravidarum
(International Research Organization for Life & Health Sciences (IROLHS), 2019-08) Prasad, Akriti; Singh, Mamta
Purpose: Hyperemesis gravidarum is one of the leading causes of hospitalization during pregnancy. This randomized study wasaimed to compare and evaluate the efficacy of granisetron and promethazine in controlling nausea and vomiting in pregnancy.Materials and Methods: This study was done in the Department of Obstetrics and Gynaecology, Nalanda Medical College andHospital, Patna, Bihar, over a period of 6 months from February 2019 to July 2019. The included patients were administeredgranisetron and promethazine randomly and evaluated for nausea and vomiting by senior gynecologist blinded to designated drugs.Results: This study showed that granisetron was more effective than promethazine in controlling nausea and vomiting inpregnant patients. Greater patient satisfaction and less adverse drug reaction were observed in women receiving granisetron.Conclusion: Hyperemesis gravidarum is a health-related problem with social, economic, and psychological dimensions.All efforts, especially simple outpatient strategies, can reduce the severity of this condition and will help pregnant women tocontinue her pregnancy with satisfaction.
Comparative Study on Serum Calcium Level in Preeclampsia Patients and Normal Pregnancy at Medical College & Hospital
(Society for Health Care & Research Development, 2019-03) Singh, Mamta; Bhattacharjee, Ila
Preeclampsia is a multi-system disorder with varied etiology. Serum calcium derangements have been reported in this group. Methods: The present comparative study included 50 cases with preeclampsia and 50 controls. History was taken from each patient and thorough clinical examination was done. Serum calcium levels were estimated and compared. Result: Serum calcium levels were lower in women with preeclampsia and the difference was statistically significant (p=0.000). Conclusion: Hypocalcaemia may have a role in pre-eclampsia.
Comparison of targeted management versus syndromatic management for abnormal vaginal discharge and the common microorganisms sensitivity associated with it
(Medip Academy, 2023-06) Singh, Mamta
Background: Abnormal vaginal discharge usually occurs in women of reproductive age group. There are many etiologies related to abnormal vaginal discharge. Abnormal vaginal discharge is second most frequent issue, behind menstrual problem in women. The main aims and objectives of this study were to compare the targeted management to syndromic management in achieving the complete cure for vaginal discharge; and to find out the common organism in vaginal discharge, in high vaginal swab culture and sensitivity.Methods: The study was a randomized control trial, where 200 patients were enrolled. The study participants were divided into 2 groups, A and B. Group A was given treatment according to the lab results. Group B was treated according to the syndromic management of vaginal discharge.Results: In group A, 88% patients having bacterial infection were cured, 10 patients were partially cured by antibiotics. 40% patients in sub group B1 were cured, 40% patients with their partners cured in subgroup B2, 37% in sub group B3 were cured. In group A, 94 patients out of 100 had organism detected on lab test. 14 patients on per speculum examination had vaginitis with cervicitis, but in lab test only vaginitis was present.Conclusions: We can conclude that syndromic management of vaginal discharge is not an efficient approach for treatment. Low response in syndromic management is due to low sensitivity of clinical examination in diagnosing the nature of vaginal discharge. Development of simple and affordable diagnostic tests that can be used is of highest priority.
Evaluation of Changing Axial Length in Eyes after Paediatric Cataract Surgery
(Society for Health Care & Research Development, 2018-09) Singh, Mamta; Sinha, BP; Mishra, Deepak
Background: Evaluation of changing axial length in eyes after paediatric cataract surgery. Aim – To assess the change in axial length of eye after paediatric cataract surgery which will help us to determine the amount of under-correction required in IOL power with increase in age. Methods: 32 patients were divided in three age groups; 0-2 years, 2-5 years and 5-10 years. Post cataract surgery, in all the patients axial length measurement, intraocular pressure recording and cycloplegic refraction was done at 6month, 1 year and after 2year of surgery. An unpaired T-test was performed to check the significance of study. Results: The change in axial length in first group(0-2 years) was higher at the end of 2 years (1.82mm) than second (1.74mm) and the third group (0.85mm). The mean axial growth of aphakic eye was higher (1.65mm) than the pseudophakic eyes of the same age group. Maximum growth rate (40-56% of the total growth) was observed in the first 6months of surgery in all the three groups. Myopic eyes in group 2 had higher mean axial growth (2.28) than the non-myopic eyes (1.28) of the same study group. Myopic eyes in the other group also had higher growth rate. Conclusion: Paediatric eye is a growing system with an eminent myopic shift which necessitates the required adjustment in IOL power to achieve emmetropia at adult age. As the rate of growth in axial length is maximum between 0-2 years of age, the required reduction in IOL power is more in this group to achieve the final status of emmetropia.
Evaluation of diagnostic efficacy of hepatobiliary scintigraphy as a diagnostic procedure in pediatric practice with special reference to cholestatic jaundice.
(2014-10) Singh, D K; Yadav, Rajesh Kumar; Singh, Mukesh Veer; Singh, Mamta; Hazra, D K; Singh, Meena
Background: The objective was to assess the diagnostic efficacy of hepatobiliary scintigraphy (Tc99 mebrofenin) in case of cholestatic jaundice in pediatric practice. Method: Study conducted on 45 cases from 0-6 yrs. of age. Out of 45 pt 20 pt excluded from study Hepatobiliary Scintigraphy (Tc99m Mebrofinin) was performed in 25 cases. Injection of Tc99m mebrofinin (1-2 mCi) IV was given to each subject. Dynamic hepatic scan was done upto initial 1 hour study and additional delayed images were taken at 4 & 24 hrs only in case of non-visualization of tracer in the intestine after initial 1 hr. study. Results: In this study hepatobiliary scintigraphy was 100% sensitive, 93.73% specific, 80% positive predictive values, 100% negative predictive value, 6.23% false positive result and virtually no false negative result for biliary atresia. Conclusion: It is concluded that Tc99m mebrofenin hepatobiliary scintigraphy has proven to be reliable noninvasive imaging modality in evaluating cholestatic jaundice in pediatric practice as it carries a high sensitive & specific value, good positive & no negative predictive value, few false positive & virtually no false negative results.
Extramedullary blast crisis in chronic myeloid leukemia--a case report.
(2005-04-09) Tondon, Rashmi; Singh, P A; Misra, Vatsala; Singh, Mamta; Mohan, Suyash
Presence of focal poliferation of myeloblasts at an extramedullary site even when peripheral blood/bone marrow blast count is less than 20% in a case of chronic myeloid leukaemia leads to a diagnosis of blast crisis. A case of focal extramedullary blast crisis with chronic myeloid leukaemia is reported here.
Female infertility: role of vaginal hormonal cytology, endometrial biopsy and endocrinological evaluation.
(2006-03-17) Afroz, Nishat; Singh, Mamta; Verma, Manju; Bansal, Vandana
Female infertility can be categorised into those who fail to ovulate (anovulatory infertility) because of some defect at hypothalamic-pituitary-ovarian axis and those who are ovulatory (ovulatory infertility), but are infertile because of some lesion present in genital tract. The role of vaginal hormonal cytology, endometrial biopsy and endocrinological evaluation in the detection of ovulation and various ovulatory dysfunction was studied in 42 infertile female patients. On the basis of cytological findings, of the 42 patients, 14 were found to be ovulatory, 26 anovulatory (which include 5 cases of atrophic changes) and 2 inconsistent due to inflammatory changes. Endometrial biopsy showed evidence of ovulation in 15, anovulation in 27 cases. Hormonal evaluation indicated some sort of endocrinological disorders in 15 patients, which may underlie anovulatory infertility in these patients, while results were within normal range in the rest 27 patients. Results of vaginal cytology and endometrial biopsy showed correlation in respect to ovulation in 93.33% of the cases.
HIV seroprevalence in patients with tuberculosis in Allahabad, North India.
(2006-04-29) Mehrotra, Ravi; Chaudhary, Mukesh Kumar; Singh, Mamta
250 patients with evidence of pulmonary tuberculosis and 50 nontubercular patients as a control group were subjected to Tuberculin test, Chest X-Ray, sputum microscopy, screening for HIV by ELISA and confirmation by Western blot if ELISA test was found positive. In the study group, 11 tested positive for HIV-1 and 239 tested seronegative, however, in the control group all patients were HIV seronegative. HIV infection was most prevalent in young males in the 21-40 year age group, with a history of tuberculosis, either residing, or working in an urban area away from their family. All our cases were of the HIV-1 serotype.
Hypertensive disorders of pregnancy: a clinical study in a rural tertiary care centre of western Uttar Pradesh, India
(Medip Academy, 2019-03) Swaroop, Neelam; Singh, Mamta; Kumari, Kalpana; Verma, Vandana
Background: The aim of study was to find out the frequency and clinical outcome in hypertensive disorder of pregnancy (HDP) in a rural tertiary care centre. Hypertensive disorder of pregnancy is a commonest medical disorder which constitutes about 12-22% of all pregnancies and it is a major cause of maternal morbidity as well as mortality world wide.Methods: It is a retrospective hospital-based study to find out the clinical outcome in different hypertensive disorder of pregnancy in a rural tertiary care centre of western Uttar Pradesh.Results: Present study showed the prevalence of HDP was 4.01% among the study population. Most of the patients were primipara ,unbooked and less than 25 years of age. The most common HDP was mild preeclampsia and HELLP was its commonest complication.Conclusions: Hypertensive disorder of pregnancy (HDP) is still a major cause of maternal mortality and morbidity. Authors intend to aware the pregnant women regarding high risk factors of pregnancy and motivate them for regular antenatal care so that complications of hypertensive disorders can be managed timely.
In-vitro studies of some chalcones on acid phosphatase.
(2011-04) Raghav, N; Jangra, Suman; Singh, Mamta; Kaur, Ravinder; Rohilla, Anita
Chemicals/compounds interact with biologically significant molecules such as enzymes, proteins, receptors, nucleic acids etc. due to the presence of various reactive groups. These interactions may result in physiological changes and are also responsible for a compound to be pharmacologically/ therapeutically active. Chalcones are known to possess significant therapeutic activities such as antiinflammatory, analgesic, antimicrobial, antioxidant, anticancer, antimalarial, antiviral, antitubercular, etc. In the present work we have evaluated the effect of chalcones on the activity of acid phosphatase of two different sources.
Intramuscular myxoma report of a case diagnosed on fine needle aspiration cytology.
(2004-04-22) Mehrotra, Ravi; Singh, Mamta; Azad, Vertika
Intramuscular myxoma is a relatively rare soft tissue tumour. Here we present a case which was diagnosed as intramuscular myxoma on cytology and confirmed on histopathology. This is the first such reported case from this country.
Management of acute corneal hydrops with compression sutures and air tamponade
(All India Ophthalmological Society, 2022-06) Singh, Mamta; Prasad, Nagendra; Sinha, Bibhuti P
Background: Acute corneal hydrops is a vision threatening complication of corneal ectasia like keratoconus, keratoconus, keratoglobus, Pellucid marginal degeneration, Terrien’s marginal degeneration and post refractive surgery keratectasia. The associated risk factors for development of corneal hydrops (CH) are early onset of keratoconus, microtrauma associated with contact lens use, eye rubbing, allergic conjunctivitis, atopy, and Down’s syndrome. With the conservative approach of management of CH, it takes longer time (in months) for corneal oedema to get resolved and there is development of vascularization and scarring. This video presents the simple technique of using compression sutures along with pneumodescemetopexy by intracameral air injection for management of CH. It led to rapid resolution of corneal oedema. It is a simple technique, with no need of special gases like C3F8 or SF6 and can be easily performed at a very basic set up. Purpose: To highlight the efficacy of simple technique of applying compression sutures and air tamponade in management of CH and to demonstrate the efficacy of anterior segment OCT in diagnosis and to assess the prognosis of a case of CH. Synopsis: A 9-year-old boy presented with CH, with anterior segment OCT showing torn descemet’s membrane and fluid pockets in corneal stroma. Four full-thickness compression sutures were applied and intracameral sterile air was used for pneumodescetopexy. The serial post operative clinical and OCT picture showed rapid resolution of corneal oedema. Highlights: This video highlights the use of OCT imaging in the diagnosis of CH and full-thickness compression sutures as the safe and effective technique in the management of acute CH.
Murine models of Aspergillosis: Role of collectins in host defense.
(2015-11) Singh, Mamta; Mahajan, Lakshna; Chaudhary, Neelkamal; Kaur, Savneet; Madan, Taruna; Sarma, P Usha
Aspergillus fumigatus, a ubiquitous fungus, causes a wide spectrum of clinical conditions ranging from allergic to invasive aspergillosis depending upon the hosts’ immune status. Several animal models have been generated to mimic the human clinical conditions in allergic and invasive aspergillosis. The onset, duration and severity of the disease developed in models varied depending on the animal strain/fungal isolate, quantity and mode of administration of fungal antigens/spores, duration of the treatment, and type of immunosuppressive agent used. These models provide insight into host and pathogen factors and prove to be useful for evaluation of diagnostic markers and effective therapies. A series of studies established the protective role of collectins in murine models of Allergic Bronchopulmonary Aspergillosis and Invasive Pulmonary Aspergillosis. Collectins, namely surfactant protein A (SP-A), surfactant protein D (SP-D) and mannan binding lectin (MBL), are pattern recognition molecules regulating both innate and adaptive immune response against pathogens. In the present review, we discussed various murine models of allergic and invasive aspergillosis and the role of collectins in host defense against aspergillosis.
Ormeloxifene can be used as first line drug in abnormal uterine bleeding: a cross sectional prospective interventional study
(Medip Academy, 2024-07) Singh, Mamta
Background: Abnormal uterine bleeding (AUB), affecting up to 30% of women globally, disrupts quality of life due to heavy or irregular menstrual bleeding without a clear underlying cause, untreated anovulatory cycle leads to hyperplasia and endometrial cancer. DUB can occur from menarche to menopause. Ormeloxifene, a selective estrogen receptor modulator (SERM), offers potential advantages for DUB treatment. Its tissue-specific effects provide both estrogenic and anti-estrogenic properties, potentially regulating AUB. This study aimed to evaluate its efficacy in managing various types of AUB (excluding pregnancy, incomplete abortion and malignancy conditions) due to its tissue-specific effects, which provide both estrogenic and anti-estrogenic properties.Methods: This cross-sectional prospective, single-center study enrolled 112 patients (menarche to perimenopause) experiencing abnormal vaginal bleeding. attending gynae OPD at Sparsh hospital (January 2023-Mar 2024). Patients with suspected malignancies, pregnancy and incomplete abortions were excluded.Results: Ormeloxifene treatment significantly improved hemoglobin levels (mean increase: 1.92 g/dl, p<0.001) and reduced endometrial thickness (mean reduction: 2.37 mm, p<0.001) across all patient. Additionally, bleeding scores (PBAC score) decreased significantly (mean reduction: 245.1, p<0.001), indicating effective control of abnormal bleeding. Notably, 4 out of 66 patients with dysfunctional uterine bleeding (DUB) did not respond to treatment.Conclusions: Our findings suggest ormeloxifene as a potential first-line therapy for various forms of DUB, particularly for women at reproductive extremes who may tolerate delayed or infrequent periods. This could be especially beneficial considering the potential side effects associated with other treatment options.
Pleomorphic lipoma of the tonsillar fossa--a case report.
(2003-07-18) Singh, Nidhi; Dabral, Charul; Singh, P A; Singh, Mamta; Gupta, S C; Jain, Sachin
Pleomorphic lipoma is a benign adipocytic tumor, commonly located in the shoulder and posterior neck region. The presence of bizarre, hyperchromatic stromal cells along with multinucleated giant cells often poses difficulty in diagnosis, especially when it arises at an unusual site like tonsillar fossa.
Prevalence and biochemical profile of subclinical hypothyroidism among female patients attending OPD of a teaching hospital in Bihar: A hospital based observational study
(Educational Society for Excellence, 2019) Singh, Mamta; Ila, Bhattacharjee.
Background: Hypothyroidism is one of the leading endocrine problems worldwide. Prevalence of high rates of subclinical hypothyroidism has been found in hilly areas. It leads increased risk of cardiovascular diseases, dyslipidemia and proneness to fractures. Materials and methods: The present cross-sectional study was conducted upon female patients above the age of 18 years attending OPD and thorough clinical and biochemical evaluation of thyroid disease was done. Results: 67.1% of the females were euthyroid. 27.2% suffered from hypothyroidism of which 9.1% was overt and 18.1% was subclinical in nature. Prevalence of subclinical hypothyroidism was higher when the age advanced. Conclusion: The prevalence of subclinical hypothyroidism is high in this area.
Prevalence of oral pre-malignant and malignant lesions at a tertiary level hospital in Allahabad, India.
(2008-04-21) Mehrotra, Ravi; Pandya, Shruti; Chaudhary, Ajay Kr; Kumar, Mahendra; Singh, Mamta
OBJECTIVE: In a previous article, we reported the prevalence rates of oral mucosal lesions in this hospital from 1990-2001. This study was planned to study the spectrum of potentially malignant and malignant oral lesions in Allahabad, North India in the subsequent years till 2007 and to assess change in pattern of prevalence, if any. MATERIALS AND METHODS: This is a single institutional retrospective study in and around Allahabad from 1990 to 2007. Data was collected year wise with reference to age, sex, site involved and histopathological findings. RESULTS: 1,151 oral biopsies were reviewed. Of these, 365 biopsies were benign, 344 were potentially malignant and 442 were malignant. The buccal mucosa was the most frequently involved site in benign and premalignant lesions, however in malignant lesions, the tongue was most common site. Oral submucous fibrosis constituted the highest number of patients in premalignant group, while in malignant group, squamous cell carcinoma was most prevalent. CONCLUSION: This study showed that potentially malignant and malignant oral lesions were widespread in the patients visiting the hospital in this region.
Radiation-related cytological changes in oral malignant cells.
(2004-07-22) Mehrotra, Ravi; Goel, Neeta; Singh, Mamta; Kumar, D
Carcinoma of the oral cavity constitutes approximately 40% of overall malignant tumours in India, with an incidence of about 56,000 cases per year. Radiation responses in oral cancer cells by cytology have not been extensively studied. 102 patients with squamous cell carcinoma of the oral cavity treated by fractionated radiotherapy were studied. Serial scrape smears were taken from each tumour before and after irradiation. The abnormal nuclear counts per 1000 malignant cells were 1.6 and 14.1(p<0.001) for micronucleation, 0.9 and 5.5 (p<0.001) for nuclear budding, 7.6 and 28.1(p<0.001) for binucleation and 2.4 and 11.7(p<0.001) for multinucleation respectively. The study showed a significant rise in radiation induced cytological responses. In addition, radiation changes observed included abnormal and incomplete divisions of a nucleus, fibroblast like appearance cells, and enlargement of nuclear size as well as cytoplasmic granulation. These changes may have an important role to play in understanding the mechanism of cell killing after radiotherapy.

Browsing by Author "Singh, Mamta"

Results Per Page

Sort Options