Browsing by Author "Singh, K K"
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Item Acrocephalosyndactyly--type I (Apert's syndrome).(1999-08-25) Singh, S K; Chaturvedi, R; Pal, S K; Singh, K K; Sinha, S K; Singh, S K; Agrawal, J KItem Aminonucleoside nephropathy. An experimental study.(1968-01-01) Mathur, K S; Wahal, P K; Singh, K KItem Anaplastic large cell lymphoma presenting as liver abscess and portal vein thrombosis.(2009-07) Chalamalasetty, S B; Madan, K; Javvaji, S; Singh, K K; Vijayaraghavan, M; Mathur, S; Kumar, L; Paul, S; Acharya, S KItem Artesunate therapy in falciparum malaria--alone or in combination.(1999-05-25) Singh, S K; Mandal, A K; Pal, S; Sinha, S K; Singh, K K; Chaturvedi, R; Singh, S K; Agrawal, J KItem Bilateral spontaneous pneumothoraces in osteogenic sarcoma and extragonadal germ cell tumour.(1994-01-01) Arora, R; Singh, P; Aggarwal, R K; Virdi, H K; Singh, K K; Kang, H SBilateral spontaneous pneumothoraces are uncommon complications of metastatic pulmonary disease especially antedating frank metastases or developing as a complication of chemotherapy. It is seen more often in osteogenic sarcoma and uncommon in extra gonadal germ cell tumour. It may correct spontaneously or need tube drainage.Item Botulinum toxin A in blepharospasm and hemifacial spasm.(1994-03-01) Behari, M; Singh, K K; Seshadri, S; Prasad, K; Ahuja, G KWe report the first Indian experience of botulinum toxin A in the treatment of blepharospasm and hemifacial spasm. Sixteen patients, 7 with essential blepharospasm, 5 with Meige syndrome and 4 with hemifacial spasm received botulinum toxin A injection. One patient received 3 courses of injections, 2 received 2 courses and the rest received only one course. The effect was observed after a latent period of less than 48 hours in all patients and lasted for a mean of 16.65 weeks. More than 70% improvement occurred after 17/20 injections (85%). Poor response was more often seen when blepharospasm was associated with oromandibular dystonia (2/5 injections). Though the duration of response and subjective score of improvement was best in patients with hemifacial spasm, the numbers were very small for any statistical evaluation. The side effects were local, transient, mild and well tolerated. The commonest side effect was blepharoptosis.Item Clinical and etiological profile of ataxic hemiparesis.(1996-06-01) Kumar, N; Sanchetee, P C; Singh, K KWe studied the clinical profile and etiology of 28 cases of ataxic hemiparesis. After a detailed neurological examination, CT scan brain (plain and after IV contrast) was done in all. Age ranged from 18 to 80 years. Acute onset of symptoms was in 22, while 6 had insidious onset. 18 patients had major infarct, while 4 patients had lacunar infarct. 2 patients were found to have haematoma (1 following head injury) and 1 each had tuberculoma, meningioma, glioma and toxoplasma granuloma. The lesions were seen in various parts of brain stem, thalamus, basal ganglion, internal capsule and frontal, parietal and temporal region. Heterogeneity as regards to etiology and localisation is being highlighted.Item Concurrent radiotherapy and weekly gemcitabine treatment of locally advanced squamous cell carcinoma of head and neck.(2013-10) Singh, K K; Jayanthi, Chavva; Nikam, Bhushan; Kharde, RohanHead and neck cancers are not curable yet but survival and local control has been increased due to concurrent treatment approach. Study was conducted to assess the role of concurrent Gemcitabine (2'2' Difluro Deoxycytidine) along with radiotherapy in treatment of Head and Neck cancers and to assess local control as well as disease free survival achieved due to chemoradiation. 100 patients were enrolled in this study, 50 patients received Radiotherapy (Group A- Control group) alone and 50 patients received Concurrent Chemoradiotherapy (Group B- Study group). Patients in study group received Gemcitabine 200mg/m2 on weekly basis for 5-7 cycles over 30 mins. Radiation delivered after 2 hours of IV infusion. Conventional radiotherapy was given in dose ranging from 66-70Gy in 33-37# for 6-7weeks. In this study, Grade 3 mucositis and Grade 2 pharyngeal toxicity were common i.e, 56% and 54% respectively in study group and 30% and 38% respectively in control group. Hematological toxicity i.e., Grade 1 leucopenia was seen in 28%. Even though the toxicities were high in study group compare to control group but they were tolerable and acceptable. The response was better in concurrent group than radiotherapy alone (Control group) CR 52% vs 40%, PR 34% vs 36% and SD 14% vs 24%. Concurrent use of gemcitabine and radiotherapy is a effective modality in treatment of head and neck cancers with acceptable toxicity. Improved local control shows that Gemcitabine acts as a sensitizers and has synergistic action along with radiotherapy.Item Curcuma longa as feed additive in broiler birds and its patho-physiological effects.(2007-03-22) Kumari, P; Gupta, M K; Ranjan, R; Singh, K K; Yadava, RBroiler birds (Vencob chicken of 3 days old) when given feed mixed with powdered rhizome of Curcuma longa (CL; @ 1 g/kg) for 42 days of age, showed significant decrease in serum uric acid and albumin as compared to control, whereas significant increase was recorded in the level of serum total protein and globulin. Level of serum glucose, alkaline phosphatase, aspartate amino transferase and calcium showed no significant variation between the two groups. Micronutrient assay revealed significantly higher level of manganese, zinc, iron and copper in treated group as compared to control group. HA/HI test revealed better humoral response against RD vaccine in CL administered birds. Haematological study showed significantly higher haemoglobin and absolute neutrophil count in treated group. Addition of CL as feed additive also resulted in better growth rate, feed consumption and F:C efficiency in the treated birds. Thus, it could be concluded that powdered CL might be a useful feed additive, since it enhanced the F:C efficiency and had nephroprotective properties.Item The encouraging role of chemo--immunotherapy in the management of recurrent breast cancer.(1982-07-01) Singh, K K; Sinha, C MItem Evaluation of multiplex Polymerase chain reaction utilising multiple targets in Mycobacterium tuberculosis direct test negative but culture positive cases: A potential method for enhancing the diagnosis of tuberculosis.(2013-10) Sharma, K; Ashkin, D; Fiorella, P; Willis, D; Dean, S; Sharma, A; Singh, K K; Lee, Y; Pedrosa, M; Singh, G; Sharma, M; S LaalPurpose: To evaluate multiplex Polymerase Chain Reaction (MPCR) utilising multiple targets (IS6110, Protein b [Pab] and MPB64 genes) in Mycobacterium tuberculosis Direct Test (MTD) negative but culture positive cases and comparison of MPCR with Real-Time polymerase chain reaction (RT-PCR) for diagnosis of tuberculosis. Materials and Methods: MPCR was carried out on 28 culture positive sputum samples. Out of 28 culture positive samples, 17 were originally reported, as MTD test negative and 11 were MTD test positive, respectively. The results of MPCR were compared with RT-PCR. To check the specifi city of the tests, MPCR and RT-PCR were also evaluated with 16 non-tuberculous mycobacterial (NTM) isolates. Results: Out of 28 culture positive sputum samples, MPCR was positive in all 28/28 samples, whereas RT-PCR was positive in 27/28 samples and MTD test was originally tested positive in six sputum samples and on repeating MTD testing, fi ve more sputum samples were positive and thus total number of MTD positive were 11/28 sputum samples, respectively. All the tests were negative on evaluation with all the 16 NTMs, thus giving specifi city of 100% to all the tests; sensitivity of MPCR, RT-PCR and MTD tests were 100%, 96.42% and 39.28%, respectively, in these specifi cally selected samples. Conclusions: MPCR may be an important tool in the rapid diagnosis of tuberculosis especially in disease endemic, resource limited countries.Item Germ cell tumour of testis.(1998-09-23) Singh, K K; Asthana, A K; Chandra, A; Singh, R KGerm cell tumour, though rare, represents most common malignancy among young men aged between 15 to 35 years. In 1990's dramatic improvement has taken place in survival rate of testicular tumours (from 10% in 1970's and 90% in 1990's). This has been possible because of effective diagnostic techniques, accurate monitoring with biological markers and use of effective platinum based combination chemotherapy in its management. The most significant improvement in survival rate has occurred in advanced stage germ-cell tumours. Seminomas are sensitive to radiation therapy and NSGCT (Non Seminomatous Germ Cell Tumours). are effectively treated by combination chemotherapy of 3 drugs of which Bleomycin is most expensive and many patient can not afford it and so compliance is poor. In the present series we have tried only 2 drug regimen consisting of Platinum and Etoposide (PE). Since January 1992 to December 1994, 40 cases of testicular tumours were treated. 16 cases received PEB regimen and 24 cases were treated by PE regimen of which only 6 cases in the former and 20 cases in the later group completed the scheduled course. Patients were given 6 cycles of PE regimen (inj. Platinum 20 mg/m2 D1-D5, VP-16 (ETOPOSIDE), 100 MG/M2 1.V. D1-D5) repeated every three weeks. Final evaluation was done in June 1996. 17/20 (85%) patients on PE regiment exhibited complete regression of the disease by the end of June 1996, I was lost to follow up, and 2 of them had the disease in progressive stage and were considered for another regimen. 18 months disease free survival was 85%. Table I. Royal Marsden Staging System Stage I: Disease econfined to testes Stage II: Intradiaphragmatic node involvement A: Less than 2 cm B: 2-5 cm C: Greater than 5 cm Stage III: Supradiaphragmatic node involvement Stage IV: Extralymphatic disease Lung, Liver, Bone etc.Item Histiocytic lymphoma simulating lepromatous leprosy--a case report.(1987-07-01) Balachandran, C; Srinivas, C R; Singh, K K; Venugopal, NHistiocytic lymphomas are known to begin with skin lesions and remain localised to the skin for months or years before visceral involvement becomes evident. We report a case of nodular histiocytic lymphoma with clinical features simulating lepromatous leprosy.Item ICMR Task Force National Collaborative Study on Identification of High Risk Families, Mothers and Outcome of their Off-springs with particular reference to the problem of maternal nutrition, low birth weight, perinatal and infant morbidity and mortality in rural and urban slum communities. Summary, conclusions and recommendations.(1991-12-01) Bhargava, S K; Singh, K K; Saxena, B NItem Images in medicine: Hashimoto's thyroiditis with orbitopathy and dermopathy.(2000-10-04) Singh, S K; Singh, K K; Sahay, R KItem In vivo and in vitro measurement of cell mediated immunity in Marek's disease: role of reticuloendothelial system.(1990-11-01) Gupta, M K; Chauhan, H V; Jha, G J; Singh, K KDinitrofluorobenzene (DNFB) contact-sensitivity test and leucocyte adherence inhibition (LAI) test were performed in this study as in vivo and in vitro tests to measure the cell-mediated immunity (CMI) in chickens subjected to stimulation of reticuloendothelial (RE) system, depletion of RE system and other experimental groups after being challenged with Marek's disease (MD) virus. It was found that CMI was lower in the birds with depleted RE system and infected control birds, whereas CMI was higher in the birds with activated RE system and vaccinated birds as revealed by DNFB contact-sensitivity test. In cases of LAI test, the number of LAI-positive birds were highest in the chicks with depleted RE system particularly in 3rd and 4th month of age, when the incidence of MD was also maximum.Item Indian experience of home based mothers card: ICMR task force study.(1991-11-01) Abraham, S; Joshi, S; Kumar, V; Patwary, A; Pratinidhi, A; Saxena, V B; Maitra, K; Singh, K K; Saxena, N C; Saxena, B NTo improve the quality of MCH services, a Home Based Mothers Card (HBMC) prepared and recommended by World Health Organization was adapted to Indian situation, and introduced in 1.5 lakh population of rural area covered by 6 participating centres under the aegis of Indian Council of Medical Research. Two thousand four hundred and forty six mothers were given this card and were followed up for a period of 2 years. Only 89.2 percent retrieval of the cards was possible after a period of 18 months. Screening of the population for "at risk" women monitoring and referral could be undertaken with the help of this card. Improved antenatal, and referral services were observed during the study period. The card (HBMC) was acceptable to the mothers as well as to the health workers, as a tool for improving the quality and coverage of MCH services being rendered at the Primary Health Centre.Item Management of eyelid lymphoma (radiotherapeutic concept).(1984-03-01) Singh, J K; Singh, K KItem Molluscum contagiosum type lesions in histoid leprosy.(1992-04-01) Mohan, L; Bhatia, P S; Nigam, P; Mishra, R; Singh, K K; Mukhija, R DItem A multicentre collaborative study of the care of mothers and infants with a comprehensive MCH care package utilizing high risk approach strategy at primary health centres: summary, conclusions and recommendations.(1995-01-01) Maitra, K; Singh, K K; Sekhar, C C; Saxena, B N