Browsing by Author "Singh, Geeta"

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    Comparative Study of Effects of Dexmedetomidine as Adjuvant to Bupivacaine and Bupivacaine Alone in Epidural Anesthesia.
    (2016-03) Singh, Vishwadeep; Singh, Geeta; Srivastava, Priyank; Singh, Lalit
    Background: Epidural anesthesia is one of the most used anesthetic technique for a lower abdominal and lower limb surgeries. Aim: The aim of the present study was to compare dexmedetomidine as an adjuvant with bupivacaine with plain bupivacaine in epidural anesthesia with respect to onset and duration of sensory and motor block, duration of analgesia, hemodynamic changes, adverse effects and sedation. Materials and Methods: A total of 60 patients of either sex with age ranging from 18 to 65 years and belonging to ASA Grades I and II physical status, scheduled for surgery under epidural anesthesia. The patients were divided into two groups with 30 patients each. Group 1 was given 20 ml 0.5% plain bupivacaine + 0.5 ml saline and Group 2 was given 20 ml 0.5% plain bupivacaine + 1 μg/kg dexmedetomidine. Results: The time of sensory onset up to T10 was shorter in Group 2 (7.10 ± 2.10 min) as compared to Group 1 (15.02 ± 2.6 min). The time of motor block onset to bromage 3 was shorter in Group 2 (14.50 ± 5.18 min) as compared to Group 1 (20.36 ± 3.4 min). The time of motor block regression to bromage 0 was longer in Group 2 (248.70 ± 28.40 min) as compared to Group 1 (152 ± 12.2 min). The time of sensory block regression and the duration of analgesia were also longer in Group 2. Conclusion: Dexmedetomidine seems to be a good choice as an adjuvant with bupivacaine in epidural anesthesia.
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    Rapid prenatal karyotyping using foetal blood obtained by cordocentesis.
    (2002-03-05) Mathur, Roli; Dubey, Sudhisha; Hamilton, Shireen; Singh, Geeta; Deka, Deepika; Kriplani, Alka; Kabra, Madhulika; Menon, P S N
    BACKGROUND: Prenatal karyotyping using foetal blood samples obtained by cordocentesis is a useful method of detecting abnormal chromosomes in the foetus. METHODS: Cordocentesis was performed in 187 cases for prenatal karyotyping between January 1995 and September 2000. Pregnant women were between 18 and 38 weeks of gestation and their ages ranged from 18 to 40 years. The common indications were ultrasonographic abnormalities (47.6%), history of previous Down syndrome (13.3%), advanced maternal age (11.7%), low maternal serum alpha foetoprotein levels (10.7%), previous child with malformation (10.7%), previous child with trisomy (chromosome 13/18) (2.6%), parent a balanced translocation carrier (1.6%) and high maternal serum alpha foetoprotein levels (1.6%). RESULTS: Analysis of 137 successful cultures showed 8 (5.2%) karyotype abnormalities. The remaining samples could not be reported due to the presence of maternal contamination of the sample (12.3%), inadequate sample (6.4%) or culture failure (9.8%). In those with an abnormal karyotype, obstetric management could be altered appropriately. CONCLUSION: In foetuses at high risk of a chromosomal aberration, a rapidly obtained karyotype is helpful in obstetric management.