Browsing by Author "Singh, Avninder"

Now showing 1 - 20 of 30
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    Angioma serpiginosum: A case series of 4 patients.
    (2016-09) Bhushan, Premanshu; Thatte, Sarvesh Sunil; Singh, Avninder
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    Annular epidermolytic ichthyosis: A rare phenotypic variant of bullous congenital ichthyosiform erythroderma.
    (2015-03) Jha, Aditi; Taneja, Jitender; Ramesh, V; Singh, Avninder
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    Asymptomatic conchal papules.
    (2013-05) Kandhari, Rajat; Ramesh, V; Singh, Avninder
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    Atypical teratoid/rhabdoid tumor of the central nervous system associated with congenital cataract.
    (2008-07-30) Singh, Avninder; Jairajpuri, Zeeba; Gupta, Vikas; Sharma, Shruti; Chand, Karam
    Atypical teratoid /rhabdoid tumor (AT/RT) of the central nervous system is a rare but highly aggressive neoplasm that usually affects young children and infants and follows a rapidly fatal course. We report a case of AT/RT in a 3-month-old male infant who also had coincidental unilateral congenital cataract even though there was no associated congenital infectious disease.
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    Choroid plexus carcinoma: Report of two cases.
    (2009-07) Singh, Avninder; Vermani, Sarvjot; Shruti, Sharma
    Choroid plexus carcinomas (CPCs) are rare malignant counterparts of choroid plexus papilloma which occur in infants and children with a predilection for the posterior fossa and have a poor prognosis. We report two cases of CPC diagnosed in a 5-year-old boy and a 12-year-old boy and discuss the clinicopathologic features.
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    Clear cell meningioma of the cauda equina in an adult.
    (2012-04) Mallya, Varuna; Singh, Avninder; Sharma, Karamchand
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    Clear cell syringoma--association with diabetes mellitus.
    (2005-07-10) Singh, Avninder; Mishra, Sharmila
    Clear cell syringomas are rare histological variants of syringoma and are clinically indistinguishable from ordinary syringomas. We report a case of clear cell syringoma associated with diabetes mellitus.
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    Disseminated cutaneous glomuvenous malformation.
    (2014-11) Jha, Aditi; Ramesh, V; Singh, Avninder
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    Exogenous ochronosis.
    (2014-02) Singh, Avninder; Ramesh, V
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    Familial reactive perforating collagenosis in three siblings.
    (2014-01) Kandhari, Rajat; Sharma, Vikas; Ramesh, V; Singh, Avninder
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    A fleshy protuberant growth on the leg.
    (2015-11) Bhushan, Premanshu; Thatte, Sarvesh Sunil; Singh, Avninder
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    Histopathological characteristics of post kala-azar dermal leishmaniasis: A series of 88 patients.
    (2015-01) Singh, Avninder; Ramesh, V; Ramam, M
    Background: Post kala azar dermal leishmaniasis (PKDL) is a sequel to visceral leishmaniasis or kala azar seen predominantly in the Indian subcontinent and Africa. Histopathological descriptions of the condition are limited. Methods: Biopsies of 88 skin and 16 mucosal lesions were evaluated for histopathological findings on formalin-fixed, paraffin-embedded tissues. Results: There were 71 (80.7%) males and 17 (19.3%) females with a mean age of 24.8 and 28.5 years, respectively. A past history of kala azar was present in 64 (72.7%) patients and post kala azar dermal leishmaniasis developed a mean of 6.2 years after visceral leishmaniasis. Of the biopsies studied, the clinical lesions were macular in 14 (15.9%), papulo-nodular in 32 (36.3%) and showed both macules and papulo-nodules in 42 (47.8%). Follicular plugging was a common epidermal finding. A clear Grenz zone was frequently noted. The dermal infiltrates were arranged mainly in three patterns: superficial perivascular infiltrates in 16 (18.1%), perivascular and perifollicular infiltrates in 24 (27.3%) and diffuse infiltrates in 41 (46.6%) biopsies. Leishman-Donovan (LD) bodies were noted in 13 (44.9%) of 69 cases on slit-skin smear and in 25 (28.4%) of 88 biopsies. In 16 patients, where both skin and mucosal biopsies were available, LD bodies were identified in 10 (62.5%) mucosal biopsies as compared to 3 (18.7%) skin biopsies. Limitations: The retrospective nature of the study and the lack of controls were limitations. Conclusion: The various histomorphological patterns of post kala azar dermal leishmaniasis are a useful clue to the diagnosis even when LD bodies have not been detected. This study also suggests that LD bodies are more frequently seen in mucosal biopsies in comparison to cutaneous biopsies.
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    Histopathological features in leprosy, post-kala-azar dermal leishmaniasis, and cutaneous leishmaniasis.
    (2013-05) Singh, Avninder; Ramesh, V
    Leprosy, cutaneous leishmaniasis, and post-kala-azar dermal leishmaniasis are common infectious diseases, the latter two being seen mainly in endemic areas. With increased migration within the country, these diseases are now frequently being seen in major cities. This brief review article focused mainly on histopathology will be useful for the dermatologists and pathologists to be familiar with the basic histopathology of these lesions.
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    Hypophyseal tuberculoma masquerading as pituitary adenoma.
    (2007-10-01) Singh, Avninder; Sharma, Shruti; Vermani, Sarvjot
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    Inoculation leprosy developing after tattooing.
    (2007-10-01) Singh, Avninder; Sharma, Shruti; Sarvjot, Vermani
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    Is CXCL10/CXCR3 axis overexpression a better indicator of leprosy type 1 reaction than inducible nitric oxide synthase.
    (2015-12) Sharma, Ira; Singh, Avninder; Mishra, Ashwani K; Singh, L C; Ramesh, V; Saxena, Sunita
    Background & objectives: Leprosy type 1 reactions (T1R) are acute episodes of immune exacerbation that are a major cause of inflammation and nerve damage. T1R are diagnosed clinically and supported by histopathology. No laboratory marker is currently available that can accurately predict a T1R. Increased plasma and tissue expression of inducible nitric oxide synthase (i-NOS) and chemokine CXCL10 have been demonstrated in T1R. We studied the gene expression and immunoexpression of i-NOS, CXCL10 and its receptor CXCR3 in clinically and histopathologically confirmed patients with T1R and compared with non-reactional leprosy patients to understand which biomarker has better potential in distinguishing reaction from non-reaction. Methods: Gene expression of i-NOS, CXCL10 and CXCR3 was studied in 30 skin biopsies obtained from patients with borderline tuberculoid (BT), mid-borderline (BB) and borderline lepromatous (BL) leprosy with and without T1R by real-time PCR. Further validation was done by immunhistochemical expression on 60 borderline leprosy biopsies with and without T1R. Results: Of the 120 patients histopathological evaluation confirmed T1R in 65 (54.2%) patients. CXCR3 gene expression was significantly (P<0.05) higher in BT- and BB-T1R patients compared to those without T1R. The CXCL10 gene expression was significantly higher (P<0.05) in BB leprosy with T1R but the difference was not significant in patients with BT with or without T1R. Immunoexpression for CXCR3 was significant in both BB-T1R and BB (P<0.001) and BT and BT-T1R (P<0.001). Immunoexpression of CXL10 was significant only in differentiating BB from BB-T1R leprosy (P<0.01) and not the BT cases. i-NOS immunoexpression was not useful in differentiating reactional from non-reactional leprosy. Interpretation & conclusions: Both CXCL10 and CXCR3 appeared to be useful in differentiating T1R reaction in borderline leprosy while CXCR3 alone differentiated BT from BT-T1R. CXCR3 may be a potentially useful immunohistochemical marker to predict an impending T1R.
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    Lipomatous metaplasia occurring within meningiomas--two case reports.
    (2005-10-22) Singh, Avninder; Sharma, Karam Chand
    Lipomatous meningiomas have recently been described as rare well defined variants of meningiomas characterized by meningothelial cells which undergo a metaplasia to adipocytes. Presence of intratumoral fat can sometimes cause confusion in preoperative radiological diagnosis. We report two such histologically unusual cases of meningiomas with significant adipose tissue metaplasia.
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    Malignant nodular hidradenoma with angiolymphatic invasion: a case report.
    (2007-07-22) Singh, Avninder; Sharma, Shruti; Verma, Saurabh; Khanna, Aarti
    Malignant nodular hidradenomas are rare variants of sweat gland carcinomas characterized by aggressive clinical behaviour. We report a case of 42-year-old female with 3 x 2 x 1 cm nodule on her foot followed by cutaneous and regional lymph node metastasis. Flow cytometry showed S-phase fraction of 72.6% and 15.8% of aneuploid cells corroborating with its aggressive nature.