Browsing by Author "Shroff, Daraius"

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    Bilateral periorbital necrotizing fasciitis following exposure to Holi colors: a case report.
    (2007-09-19) Chauhan, Deepender; Arora, Ritu; Das, Sima; Shroff, Daraius; Narula, Ritesh
    Holi festival is celebrated in India traditionally by applying colors on one another. Various ocular adverse effects of these colors have been reported including conjunctivitis and corneal abrasion. We report a case of bilateral periorbital necrotizing fasciitis, following exposure to Holi colors. General physicians might encounter more such cases after exposure to Holi colors. In India, these colors are prepared on a small scale and lack any quality checks. Use of such toxic colors should be discouraged, and all doctors should caution people against using synthetic dyes. This case report highlights the need to put manufacturing of Holi colors under guidelines of the Food and Drug Cosmetic Act and the Bureau of Indian Standards.
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    Dysmyelination of the Cerebral White matter with Microdeletion at 6p25.
    (2011-09) Kapoor, Seema; Mukherjee, Sharmila Banerjee; Shroff, Daraius; Arora, Ritu
    A 6-year old boy presented with mental retardation, hypotonia, abnormal facies, impaired hearing, protuberant eyes, visual impairment, short stature, Axenfeld- Rieger anomaly, a bicuspid aortic valve, and bilateral sensorineural deafness. CT scan of head suggested dysmyelination of the subcortical and periventricular white matter. FISH revealed a subtelomeric microdeletion encompassing both FOXC1 and FOXF2 loci within 6p25. Dysmyelination of the central nervous system has been infrequently described earlier in patients with 6p25 deletion.
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    Familial calcific band-shaped keratopathy: report of two new cases with early recurrence.
    (2007-01-27) Arora, Ritu; Shroff, Daraius; Kapoor, Seema; Nigam, Sonu; Narula, Ritesh; Chauhan, Deepender; Jain, Priyanka
    We report two siblings with the rare entity of familial calcific band-shaped keratopathy (BSK). Detailed ophthalmic and systemic investigations failed to reveal any underlying causative pathology. Topical disodium ethylenediamine-tetraacetate (EDTA) was applied for 30 min to all four eyes. In addition the right eye of the younger sibling required a superficial keratectomy. An improvement in corneal clarity was seen in the immediate postoperative period in both siblings. Histopathology of the keratectomy specimen revealed linear extracellular sub-epithelial granular calcium deposits. However, an early recurrence was noted in all four eyes at four weeks postoperatively. We report the second instance in the English literature of this entity. Band-shaped keratopathy presenting without an obvious etiology merits a complete systemic and ophthalmic workup. Patients with familial idiopathic BSK could be cases with poor prognosis for treatment with EDTA due to an early recurrence of the disease.
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    Initial experience with brolucizumab for neovascular age-related macular degeneration (nAMD) in India – Multicentric, real-world study
    (Wolters Kluwer – Medknow, 2024-12) Singh, Deependra Vikram; Agarwal, Aniruddha; Goyal, Anubhav; Shroff, Daraius; Singh, Jatinder; Kumar, Pradeep; Reddy, Raja Rami; Venkatesh, Ramesh; Narnaware, Shilpi; Joshi, Shrinivas; Delhi Retina Forum Study Group; Singh, Deependra V; Narula, Ritesh; Joshi, Aishwarya; Agarwal, Aniruddha; Goyal, Anubhav; Gupta, Charu; Shroff, Daraius; Anantharaman, Giridhar; Singh, Jatinder; Kumar, Pradeep; Bawankule, Prashant; Reddy, Raja Rami; Jain, Rajiv; Venkatesh, Ramesh; Tiwari, Ruchir; Sugumar, Shalini; Gupta, Shashank Rai; Narnaware, Shilpi; Joshi, Shrinivas; Choudhary, Somendra P
    Purpose: To evaluate the anatomic and visual outcomes and safety profile of initial Indian eyes with neovascular age?related macular degeneration (nAMD) treated with intravitreal injection (IVI) of brolucizumab. Methods: This retrospective multicentric, real?world study enrolled consecutive eyes with nAMD that were treated with IVI brolucizumab after it was launched in India in October 2020. Data collected for each eye included best?corrected visual acuity (BCVA), central subfield thickness (CSFT), subretinal fluid (SRF), and intraretinal fluid (IRF) status at 6, 12, and 24 months follow?up. Also recorded were the lens status, treatment protocol, number of injections received before enrollment (in switch?over cases), total number of injections, and adverse effects noticed during the study period. Primary outcomes were change in BCVA, CSFT at follow?up visits, and incidence of intraocular inflammation (IOI). Secondary outcomes were profile of macular neovascularization, treatment protocols, mean number of injections, and maximum injection?free interval observed in eyes treated by pro?re?nata(PRN) protocol. Results: In total, 331 eyes received a mean of 3.55± 1.83 injections. Most frequent treatment protocol was PRN(53%). BCVA data was available for 100%, 96%, and 74% eyes at 6, 12, and 24months follow?up. BCVA and CSFT improved significantly (P < 0.001) at all follow?ups. Two hundred and seventy?six(83.38%) out of 331 eyes received more than one injection; out of these, 241 (87.3%) eyes that were treated by PRN protocol could achieve mean “maximum injection?free interval” of 19.43± 8.82 weeks. IOI and retinal vasculitis were reported in 2.11%(7/331) and 0.60% (2/331) eyes, respectively. None of the eyes with IOI or vasculitis lost any vision at the final follow?up.Conclusion: This study demonstrated favorable visual and anatomic outcomes and safety profile for eyes with nAMD treated by IVI brolucizumab. Mean maximum injection?free interval in eyes treated with PRN was 19weeks.
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    Peters plus syndrome.
    (2008-06-15) Kapoor, Seema; Mukherjee, Sharmila Banerjee; Arora, Ritu; Shroff, Daraius
    A 10-year-old boy, issue of unrelated parents presented with visual impairment, short stature and mental retardation. The presence of a Peters' anomaly, mental retardation, disproportionate short stature, skeletal abnormalities and distinctive facial features (broad forehead, telecanthus, cupid bow shaped upper lip) established the diagnosis of Peters' plus syndrome. Analysis of his genomic DNA revealed a homozygous deletion in the beta1,3-galactosyltransferase-like gene (B3GALTL), a recently identified gene.
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    Retinal vasoocclusive spectrum following COVID-19
    (All India Ophthalmological Society, 2022-04) Shroff, Daraius; Kumar, Sandeep; Naidu, Anushree; Gupta, Charu; Shroff, Cyrus M
    The coagulation abnormalities and thromboembolic complications of coronavirus 2 (SARS-CoV-2) are now a well-established fact. The hypercoagulable state, the tendency for thromboembolism, and a cytokine surge state have been the exclusive reasons for multiorgan failure and other morbidities that have been regularly reported in COVID-19 patients. Ocular involvement in patients with active disease and those who have recovered is uncommon but not rare. We report a case series of four patients with CRVO, BRVO, CRAO, and vitreous hemorrhage in patients with proven COVID-19 infection and no other systemic ailments. The case series also tries to correlate the elevated D-dimer values, which signify a plausible prothrombotic state with the vaso-occlusive phenomenon in the retina leading to significant visual morbidity.
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    Surgeon’s perceptions and preferences in the management of idiopathic macular hole
    (Wolters Kluwer – Medknow, 2025-01) Kumawat, Devesh; Dave, Vivek Pravin; Venkatesh, Pradeep; Shanmugam, Mahesh P; Nagpal, Manish; Gupta, Vishali; Bhende, Pramod S; Babu, Naresh; Narayanan, Raja; Shroff, Daraius
    Purpose: The management of idiopathic macular holes (iMH) has evolved over time with various modifications in surgical approach. The study aimed to survey the surgeons’ preferences in the management of iMH in current times. Design: Cross?sectional descriptive survey. Methods: A 12?item questionnaire addressing the key aspects of iMH management was sent, between October 2022 to November 2022, by personal correspondence to 104 vitreoretinal specialists, actively practicing and performing iMH surgeries at various institutes in India. The responses were gathered till January 2023 and analyzed as per appropriate statistical methods. Results: Ninety?one retina specialists responded to the survey (response rate of 87.5%) with a median annual surgical load of 30 cases (range: 5–150). Most respondents had similar views on patient selection, combined phaco?vitrectomy, internal limiting membrane (ILM) staining, ILM peel initiation and propagation, tamponade, postoperative positioning, and prognostic factors. The preferred approach for peel initiation was “pinch and peel,” but “scrape and peel” was equally recommended for beginners. Most respondents considered iMH >600 microns in size as large and used additional surgical maneuvers for large and failed cases such as ILM flap, large flap, macular detachment, platelet?rich plasma application, and amniotic membrane graft. The three most important visual prognostic factors were duration, preoperative vision, and MH size. Conclusions: The practice of surveyed surgeons performing iMH surgery was uniform in several aspects. There is a need to create consensus on the preferred ILM peel technique among trainee surgeons, revisit the iMH size classification, and standardize the surgical approach as per hole size and characteristics.
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    Unilateral Purtscher-like retinopathy post-COVID-19
    (All India Ophthalmological Society, 2022-10) Shroff, Daraius; Kumar, Sandeep; Naidu, Anushree; Gupta, Charu
    A 32-year-old male with no known systemic illness presented with unilateral Purtscher-like retinopathy in his left eye 2 weeks after recovering from a severe COVID-19 infection. Fundus examination revealed areas of intraretinal whitening and few cotton wool spots. Multimodal imaging findings were consistent with embolic occlusion of capillaries seen in Purtscher-like retinopathy. The case highlights the effect of virus-directed coagulation cascade activation leading to unilateral microvasculopathy in our patient. The case adds to the spectrum of COVID-19 retinopathy and presses that retina screening strategies should be established for patients suffering from or recovering from severe COVID-19 infection.