Browsing by Author "Shimada, M"
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Item Diethylcarbamazine: inhibitory effect on acetylcholinesterase of Dirofilaria immitis and Brugia pahangi.(1989-06-01) Fujimaki, Y; Sakamoto, M; Shimada, M; Kimura, E; Aoki, YAnti-acetylcholinesterase activity of diethylcarbamazine (DEC) was studied. Acethylcholinesterase (AchE) of adult worms of Dirofilaria immitis, those of the 4th-stage larvae, early 5th-stage larvae and adults worms of Brugia pahangi, and that of hamster brain tissue were all inhibited by DEC. Michaelis constant (Km) of D. immitis and B. pahangi adult worm AchE were 1.47 x 10(-4) and 1.81 x 10(-4) M respectively. DEC was a competitive inhibitor of the filarial AchE. Inhibition constant (Ki) for AchE of D. immitis and B. pahangi adult worms were 2.56 x 10(-4) and 6.39 x 10(-4) M, respectively. DEC is a less potent anticholinesterase inhibitor, because Ki of DEC is 10(4) times higher than that of eserine, a potent anti-cholinesterase agent.Item A probable case of Leishmaniasis (Espundia) acquired in Japan.(1977-12-01) Okano, K; Shimada, M; Go, S; Miyano, Y; Tanaka, M; Watanabe, Y; Tagami, E; Asai, T; Inoki, SA case of mucocutaneous leishmaniasis is described in a Japanese patient who had never been abroad, suggesting either contact with an infected person from Brazil or the presence in Japan of indigenous cutaneous leishmaniasis. This case illustrates the value of electron microscopic examination in such infections, since it provided the definitive diagnosis.