Browsing by Author "Sharma, M"
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Item Acceptance of COVID-19 Vaccination Among Health Care Workers in India(MRI Publication Pvt. Ltd., 2023-03) Tiwari, N; Goyal, A; Sharma, M; Kumar, D; Yadav, C; Gite, A.Background: The coronavirus disease 2019 has been spread almost all over the world in the last two years, including in India. Vaccines are a critical tool in the battle against COVID-19, and India has flagged the largest vaccination drive on 16 January 2021. Although public acceptance was varying, which can lead to non-acceptance. Aim & Objective: To estimate an acceptance of the COVID-19 vaccine and its associated factors. Settings and Design: An analytical cross-sectional study among health care workers in India Methods & Material: It was conducted using a validated, self-administrated online survey questionnaire, and data were analyzed using SPSS 23 version. The outcome variable was healthcare workers’ acceptance of a COVID-19 vaccine. Results: A total of 450 HCWs participated, including 205(45.6%) women and 245(54.4%) men. A total of 270 (60%) subjects will accept vaccines, while 33.3% were unwilling to accept and wait for vaccines. Male gender (OR=3.14), being married and experienced (OR=11.49), vaccine effectiveness (OR=6.4), vaccine safety (OR=3.4), and past history (OR=2.28) were significantly associated. On applying logistic regression for associated factors, gender (B= -1.145, S.E.= 0.200, Wald 32.748), being married (B= -1.482, S.E.= 0.216, Wald 46.937), for experienced (B= -0.865, S.E.= 0.200, effectiveness (B= -1.856, S.E.= 0.245, wald 57.431), Safety (B= -1.224, S.E.= 0.202, Wald 36.633) and past history (B= -0.357, S.E.= 0.248, Wald 2.071) found significant. Recommendation: Proper information is crucial and healthcare workers’ attitudes about vaccines are an important factor for acceptance and recommendation of the vaccine to the public for population-wide coverage.Item Accuracy of noncycloplegic photorefraction using Spot photoscreener in detecting amblyopia risk factors in preschool children in an Indian eye clinic(All India Ophthalmological Society, 2020-03) Sharma, M; Ganesh, S; Tibrewal, S; Sabharwal, S; Sachdeva, N; Adil, M; Chaudhary, J; Siddiqui, ZPurpose: To evaluate the accuracy of Spot photoscreener (PS) as a noncycloplegic photorefractor in detecting amblyopia risk factors (ARFs) in preschool children in an Indian eye clinic setting. Also, to derive appropriate cutoff values for screening to obtain maximum sensitivity and specificity of the device in detecting ARF. Methods: This was a cross-sectional study conducted in the outpatient pediatric eye clinic at a tertiary eye care institute. A Spot PS was used to screen all the children between the ages of 6 months and 5 years that presented to the eye clinic from August 2018 to October 2018. This screening was followed by a complete eye examination, including cycloplegic refraction by a masked examiner. The 2013 American Association for Pediatric Ophthalmology and Strabismus (AAPOS) guidelines were considered the standard cutoff values for clinically significant refractive error in children younger than 5 years of age. Results: The study comprised of 219 children. The Spot PS diagnosed 135 (61.64%) children with ARF as compared with 124 (56.62%) children detected by clinic examination. For ARF detection, the Spot photoscreeneer had 85.48% sensitivity, 69.47% specificity, 78.52% positive predictive value and 78.57% negative predictive value. The sensitivity for detection of strabismus and hypermetropia was very low (42% and 36%, respectively). The 95% limits of agreement ranged from ?5.48 to +5.59 diopters (D) with a bias of 0.06 D for spherical equivalent between noncycloplegic photorefraction and cycloplegic refraction. Conclusion: The Spot PS may be used as a screening tool to detect ARF in children younger than 5 years of age keeping its limitations in consideration. However, the performance can be improved by modifying the cutoff values for the referral.Item Acute phenothiazine reaction.(1988-06-01) Sharma, M; Gandhi, V K; Taluja, R K; Mathur, P SItem Aetiologic factors in male infertility: clinical, microbiological and hormonal evaluation.(1992-03-01) Nalini, K; Sethi, B K; Sharma, M; Dash, R JSeventy two infertile men were studied. History of small pox and mumps infection was noted in 4 and 3 patients respectively. Seven patients had varicocele (9.2%), and small atrophic testes were found in 9 (12.5%). Azoospermia was reported in 41 (58.3%) and oligospermia in 17 (23.6%), and 14 patients (19.4%) had normal sperm counts. Mycoplasma were grown from urethral swabs in 25 (35%) patients. Mean LH and FSH were elevated in azoospermics (p less than 0.001), E2-17B in oligospermics (p less than 0.001) and FSH in normospermic (p less than 0.01) patients. Hypergonadotropism suggestive of primary testicular failure was recorded in 43 (59.7%) patients. Hypogonadotropism was noted in 3 (4%) and hyperprolactinemia due to pituitary microadenoma induced infertility in only one patient. No aetiology could be determined in 11 (16%) patients.Item Alarming resistance of Neisseria gonorrhoeae in a tertiary care hospital of North India(Indian Association of Medical Microbiologists, 2018-06) Sharma, M; Rizvi, M; Gupta, R; Azam, M; Khan, HM; Parvez, A; Shukla, IBackground: This study attempted to elucidate the spectrum of sexually transmitted infections in a tertiary care centre in North India and to assess the antimicrobial resistance in Neisseria gonorrhoeae. Materials and Methods: Antimicrobial resistance pattern of N. gonorrhoeae was determined by the standard techniques. Genotypic detection of gyrA, parC and blaTEM genes was also carried out. The results of gyrA gene by polymerase chain reaction were confirmed by DNA sequencing. Results: N. gonorrhoea was identified in 10 (4.98%) patients, and antimicrobial sensitivity was performed in seven patients. All the seven patients tested were quinolone-resistant N. gonorrhoeae (QRNG), 5/7 were penicillinase-producing N. gonorrhoeae, 1/7 was chromosomally mediated penicillin-resistant N. gonorrhoeae and 3/7 were tetracycline-resistant N. gonorrhoeae. Minimal inhibitory concentration (MIC) by E-test was performed in five strains, and we observed that MIC90 for ciprofloxacin was ?4 ?g/ml, for penicillin was ?6 ?g/ml and for tetracycline was 12 ?g/ml, which clearly brackets them as resistant isolates. The presence of TEM gene was confirmed genotypically in six out of seven cases. In all seven cases, gyrA and parC were observed, thus confirming their QRNG status. Conclusion: Alarming increase in the resistance to commonly used antimicrobials for gonorrhoea in our study, especially of fluoroquinolones, is a clarion call for the urgent need for prudence in prescribing them. Observing the rampant resistance exhibited by N. gonorrhoeae, it is clear that the day is not far when it will acquire a superbug status and become intractable to treatment by the available antibiotics.Item Alteration in the acceptor side of photosystem II of chloroplast by high light.(1996-06) Dwivedi, U; Bhardwaj, R; Sharma, MThe effect of high light on the acceptor side of photosystem II of chloroplasts and core particles of spinach was studied. Both Vmax and apparent Km for DCIP were altered in photoinhibited photosystem II core particles. The double reciprocal plot analysis as a function of actinic light showed increased slope in chloroplasts photoinhibited in the presence of DCMU. Exposure of chloroplasts to high light in the presence of DCMU did not protect the chloroplast against high light induced decrease in Fm, level. Further the high light stress induced decrease in Fm level was not restored by the addition of DCMU. These results suggest that the high light stress induced damage to chloroplast involves alteration in the binding site for QB on the DI protein on the acceptor side of photosystem II.Item Antiepileptic activity of Panax ginseng against pentylenetetrazole induced kindling in rats.(2001-10-09) Gupta, Y K; Sharma, M; Chaudhary, GIn the present study, Panax ginseng was evaluated for its antiepileptic activity against pentylenetetrazole (PTZ) induced chemical kindling in rats. PTZ was injected at the dose of 30 mg/kg, i.p. on alternate days and the occurrence of generalized tonic clonic convulsions were considered as the end point. One group received Panax ginseng every day, at a dose of 100 mg/kg, 30 min prior to PTZ injection whereas the other group received an equal volume of distilled water to serve as control. In a separate group the rats were evaluated for motor performance tests after Panax ginseng. The rats treated with Panax ginseng showed significant protection as compared to vehicle treated PTZ injected rats. The study suggests to potential of Panax ginseng against seizures.Item Antimicrobial resistance in the environment: The Indian scenario(Indian Council of Medical Research, 2019-02) Taneja, N; Sharma, MAntimicrobial resistance (AMR) continues to pose a significant public health problem in terms of mortality and economic loss. Health authorities of several countries including India have formulated action plans for its containment. In this fight against AMR, it is important to realize the contribution by all the following four spheres: humans, animals, food and environment. This review incorporates all the spheres of One Health concept from the Indian perspective. India has one of the highest rates of resistance to antimicrobial agents used both in humans and food animals. The environment, especially the water bodies, have also reported the presence of resistant organisms or their genes. Specific socio-economic and cultural factors prevalent in India make the containment of resistance more challenging. Injudicious use of antimicrobials and inadequate treatment of waste waters are important drivers of AMR in India. Use of sludge in agriculture, improper discard of livestock animals and aquaculture industry are considered AMR contributors in other countries but Indian data regarding these are lacking. Efforts to combat AMR have been initiated by the Indian health authorities but are still at preliminary stages. Keeping in view the challenges unique to India, future directions are proposed.Item Arteriovenous malformation of the pancreatic head – difficulties in diagnosis and treatment.(2011-01) Sharma, M; Bedi, M M S; Mahesh, S; Gandhi, M D; Antony, R; Mukkada, R J; Lekha, V; Ramesh, HA patient with pancreatic arteriovenous malformation who presented diagnostic and therapeutic difficulties is presented. The initial tests appeared to suggest inflammatory bowel disease, but the diagnosis was clinched by the finding of blood issuing from the ampulla of Vater. Repeated angiographic embolization did not obliterate the vascular malformation, and the symptoms eventually resolved after Whipple’s pancreaticoduodenectomy.Item Assessment of malnutrition in alcoholic and non alcoholic cirrhotics.(1999-07-01) Narayanan, L; Chawla, Y; Bhalla, A K; Sharma, M; Dilawari, J BOBJECTIVE: To study the nutritional status in patients with chronic liver disease using anthropometric techniques. METHODS: A total of 60 cirrhotic patients (30 Alcoholic (AC), 30 Non-alcoholic (NAC) and 30 control (CO) subjects were studied. Nutritional status was assessed using anthropometric measurements such as stature, body weight, body mass index, (BMI), skinfold thickness measurements and mid upper arm muscle circumference. Serum protein, serum albumin and globulin were measured. RESULTS: The skinfold thicknesses were significantly lower in NAC group of patients. In contrast the AC group of patients showed significantly lower mid upper arm muscle circumference values. Both groups of cirrhotic patients showed significantly lower total serum protein and serum albumin levels. CONCLUSION: Body fat is relatively more affected in NAC group of patients and muscle mass is more affected in AC group of patients.Item Assessment of mental well-being in first year medical students(Mrs Dipika Charan of MedScience (India) Publications, 2023-02) Sharma, M; Gupta, S; Sharma, SK.Background: Mental health is one of the most important domains of the overall health of an individual and has received a worldwide concern as an important public health issue. In the present times, health professionals have to face a lot of issues regarding the work stress for providing the best healthcare to the needed ones. Hence, the foundation for emerging as an efficient health-care provider starts from the time when one enters into a medical college. Aim and Objectives: The aim of the study was to assess the status of mental health in first medical students. Materials and Methods: A self-administered questionnaire based on Depression, Anxiety, and Stress Scale-21 (DASS-21) scale was provided to the participants who were willing to participate in the study. Percentage of total subjects enrolled was categorized into normal, mild, moderate and severe degrees of depression, anxiety, and stress depending on feedback provided by them based on DASS-21 scale. Results: Mild depression was present in 40% and moderate degree of depression was seen in 50% of total subjects taken. About 70% of students reported a state of moderate anxiety and 20% students reported severe anxiety. Severe stress was seen in 30% of total subjects taken and 60% of subjects reported moderate degree of stress. Conclusion: It was reported that moderate level of depression, anxiety, and stress is present in a significant percentage of 1st year medical students as indicated by the score of DASS-21 scale.Item Association of plasma lipoproteins with angiographically defined coronary artery disease.(1995-05-01) Bahl, V K; Vashish, S; Chandra, S; Sharma, M; Wasir, H SLipoprotein (a) and other lipoprotein variables have been correlated with angiographic severity of coronary artery disease. However, pattern of lipoprotein (a) distribution in various racial groups has been found to be different. To study this relationship in the Indian patients, plasma levels of lipoprotein (a) and other lipoprotein variables were examined in 144 consecutive patients undergoing coronary angiography. Total cholesterol and cholesterol content of various lipoproteins were assayed by chemical methods, and in 116 patients lipoprotein (a) was detected by gel electrophoresis. Lipoprotein (a) was positive in a total of 78 (67%) patients, and its positivity in the four angiographic groups with normal coronaries, single vessel, double vessel, and triple vessel disease was 69, 78, 61 and 67 percent respectively. Interestingly, lipoprotein (a) greater than 75 percentile tended to be more frequent in patients with increasing severity of coronary artery disease: 15%, 21%, 25% and 28% in the four groups, respectively. However, this was not statistically significant. Plasma levels of total cholesterol, cholesterol content of other lipoproteins and triglycerides were not significantly different in these four groups of patients. This study, therefore, shows that there is no significant correlation of lipoprotein (a) positivity with angiographic severity of coronary artery disease in our group of Indian patients, although higher values are more frequently present in patients with severe disease.Item Auramine-O Staining vs Ziehl Neelsen Staining: Advantages and Disadvantages(Jaypee Brothers Medical Publishers Pvt. Ltd, 2023-03) Sharma, M; Broor, S; Maheshwari, M; Sharma, M; Sudan, DS.Background: Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is still a major public health concern around the world. Prompt detection of active tuberculosis cases helps in timely therapeutic intervention and reduces community transmission. Despite limited sensitivity, conventional microscopy is still used to diagnose pulmonary tuberculosis in high-burden nations such as India. This study, therefore, was aimed at assessing the diagnostic performance of microscopy by Ziehl Neelsen (ZN) and auramine (AO) staining in the diagnosis of pulmonary tuberculosis. Materials and methods: A prospective comparative study was done on the sputum samples of 2,395 adult patients from November 2018 to May 2020 suspected of having pulmonary tuberculosis visiting the Designated Microscopic Centre of SGT Medical College, Budhera, Gurugram. Each sample was subjected to ZN staining, and AO staining as per NTEP guidelines. Results: Out of the 2,395 samples studied, 161 (6.76%) and 224 (9.35%) were positive by ZN and AO staining methods respectively. Pauci-bacillary cases detected by AO were more than ZN staining. There were 63 more sputum samples detected by AO staining which were missed by ZN microscopy. Conclusion: When compared to conventional ZN staining, the auramine staining technique is more sensitive and takes less time to diagnose pulmonary tuberculosisItem Ayurvedic Medicinal Plants as Psychotherapeutic Agents-A Review.(2013-04) Sharma, M; Sahu, S; Khemani, N; Kaur, RDuring the last decade herbal drugs has been gaining growing popularity throughout the world. According to world federation for mental health, the mental and neurological disorders affect more than 450 million people around the world. Modern science is trying to control this problem but in most cases it has become unsuccessful. Under such conditions herbal drugs can produce beneficial effects. Modern psychotropic drugs have many side effects. So there is a need to find an alternative treatment from herbal plants which can cure these diseases. Studies undertaken in different parts of the world have proved presence of important pharmacological activities in many plants. This review describes some important plants effective in mental disorders.Item B-Lynch brace suture simple surgical technique for managing post-partum haemorrhage - report of three cases.(2005-10-02) Saha, R; Sharma, M; Karki, C; Pande, SPost-partum haemorrhage is a major contributor to maternal morbidity and mortality. Numerous medical and surgical therapies have been used but none has been uniformly successful. Three cases which were managed successfully with brace suture following failure of medical management for post-partum haemorrhage are being presented. The ease and usefulness of this procedure as a life saving measure, its relative safety and its capacity for preserving the uterus and thus fertility is high lighted.Item Bilateral variation in the Origin of Sternocleidomastoid muscle.(2013-07) Kaur, J; Sharma, T; Wadhwa, A; Sharma, MMorphological variations of sternocleidomastoid are not uncommon. During our routine dissection, in the department of anatomy PIMS Jalandhar, we encountered a rare case of presence of third head of sternocleidomastoid, bilaterally. This anomalous head is arising from clavicle lateral to the clavicular head of sternocleidomastoid muscle. This report not only adds to the knowledge of anatomists but will hold good to surgeons, anaesthetists and radiologists as well.Item Biochemical responses of Camellia sinensis (L.) O. Kuntze to heavy metal stress.(2001-01-02) Basak, M; Sharma, M; Chakraborty, UThree heavy metals-mercury (II), copper (II) and nickel (II), each at a concentration of 10 and 100 micrograms/ml, were tested for their effects on various biochemical constituents of tea leaves. Both NI (II) and Hg (II) decreased the phenolic contents, while Cu (II) increased it to some extent. The metal treatments enhanced the activity of phenyl alanine ammonia lyase (PAL), while the activity of poly phenol oxidase (PPO) showed a decline. Heavy metal stress also decreased the chlorophyll content of the leaves, along with a significant reduction in Hill activity. Proline content increased significantly in all treatments.Item Biological basis of treatment of stage III breast cancer. A pilot study.(1987-09-01) Sharma, M; Shukla, HItem Biomedical waste management: Incineration vs. environmental safety.(2010-07) Gautam, V; Thapar, R; Sharma, MPublic concerns about incinerator emissions, as well as the creation of federal regulations for medical waste incinerators, are causing many health care facilities to rethink their choices in medical waste treatment. As stated by Health Care Without Harm, non-incineration treatment technologies are a growing and developing field. Most medical waste is incinerated, a practice that is short-lived because of environmental considerations. The burning of solid and regulated medical waste generated by health care creates many problems. Medical waste incinerators emit toxic air pollutants and toxic ash residues that are the major source of dioxins in the environment. International Agency for Research on Cancer, an arm of WHO, acknowledged dioxins cancer causing potential and classified it as human carcinogen. Development of waste management policies, careful waste segregation and training programs, as well as attention to materials purchased, are essential in minimizing the environmental and health impacts of any technology.