Browsing by Author "Sharma, Seema"

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    Analysis of Factors Associated with Success Journey of Newly Entered Medical Students in a Rural Medical College of Haryana
    (International Society for Contemporary Medical Research, 2020-01) Sharma, Seema; Kumari, Sneh; Kataria, Pooja; Banga, Diksha; Sindwani, Pooja; Dhingra, Neha; Saini, Jyoti; Ritu
    Introduction: Competition for admission to medical collegein India is intense as the number of applicants for nationaleligibility cum entrance test (NEET) always exceeds theavailable seats. The choice of a career in the medical fieldis a complex personal decision influenced by a multitude offactors. Current study was done with the objectives to studysocio-demographic profile of newly selected medical students,to assess reasons of choosing medical stream as a career andto determine the association of socio-demographic and otherfactors with number of attempts taken by the medical studentsfor selection.Material and methods: This was a cross–sectional studycarried out among 96 newly entered medical students ofMaharaja Agrasen Medical College, Agroha (Dist. Hisar),Haryana. Appropriate statistical tests like chi-square (χ2)test and Fisher’s exact test were applied and mean, mode,percentages were also measured.Result: Out of total 39 students (40.6%) belonged to familywhere one or more member was in medical profession.However 86 students (89.6%) choose the medical professionby their own choice. Most of students (72.9%) were attendingregular classes during 11th & 12th in their schools. Maximumnumber of students (46.9%) cleared the NEET in their 2ndattempt. Maximum selection was in students who spent 9-12hours for study for preparation. Out of total 60.4% studentsspent 5-7 hours for sleep during preparation period. Out oftotal 91.7% students were joined coaching for preparationpurpose. Majority of students (67.7%) migrated from theirnative place for study purpose.Conclusion: In our study maximum students have chosenmedical profession because of their personal interest. Inpresent study maximum newly entered medical students werethose who have attended schools regularly in 11th and 12thclasses. Adequate sleep hours for students play constructiverole in favorable outcome.
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    Awareness about HIV/AIDS in first year medical students of Rohtak.
    (2008-09-28) Kalhan, Meenakshi; Vashisht, B M; Sharma, Seema
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    Basal cell carcinoma in a child with xeroderma pigmentosum: Clinical response with electron beam radiation therapy.
    (2013-07) Sahai, Puja; Singh, Karuna; Sharma, Seema; Kashyap, Seema; Mohanti, Bidhu Kalyan
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    Bone marrow biopsy in Hodgkin's disease.
    (2004-07-22) Sharma, Seema; Ahuja, Arun; Murari, Manjula
    Bone marrow biopsies of 58 untreated patients with Hodgkin's disease were evaluated. Marrow involvement was seen in 36.2 % cases. Positive marrow biopsies were seen mainly in patients with clinical stages III and IV. Bone marrow involvement was most common in patients with less than 15 years of age and in males. HD patients with mixed cellularity had highest incidence of marrow involvement while none of the patients with lymphocytic predominance showed BM involvement. Focal infiltration was found to be more common. Bone marrow aspiration smears were negative in majority of cases with positive marrow biopsies. Thus BM trephine biopsy is a simple tool for assessment of disease spread.
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    Bone marrow involvement by metastatic solid tumors.
    (2003-07-18) Sharma, Seema; Murari, Manjula
    A five year experience with bone marrow aspirates and biopsies positive for metastatic carcinoma is reviewed. Marrow examination in 25 cases detected metastasis. The common primary tumors with marrow metastasis were neuroblastoma, carcinoma breast and prostate. In 56% cases primary site could not be ascertained from bone marrow as metastatic tumor showed undifferentiated morphology. The study demonstrates the usefulness of combining trephine biopsy with aspirate examination for increased detection of bone marrow metastasis.
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    Clinical, Hormonal and Metabolic Profile of Different Phenotypes of Polycystic Ovarian Syndrome
    (Ibn Sina Academy of Medieval Medicine & Sciences, 2019-01) Mahala, Neeti; Sharma, Seema
    Background: Polycystic ovarian syndrome (PCOS) is one ofthe most frequently encountered hormonal disorder withmetabolic abnormalities in females that can present at puberty,during reproductive age or even after menopause. Therefore,the aim of this study was to evaluate the occurrence of differentphenotypes among PCOS women and to compare thehormonal assay and metabolic profile of different phenotypesof PCOS.Materials & Methods: The present study was an observationalstudy conducted on 160 women of the age group of 16-35years and diagnosed with PCOS, in the department ofobstetrics and Gynecology at Mahatma Gandhi MedicalCollege and Hospital, Jaipur from January 2017 to July 2018.Diagnosis of PCOS was done by using the ESHRE/ASRMcriteria and subjects were divided into 4 phenotypes by usingthe all probable combination of Rotterdam criteria. Hirsutismwas assessed by using Modified Ferriman Gallwey score.Score <8 - Normal, 8-15- Mild and >15 indicate moderate tosevere hirsutism.Results: 160 PCOS women were distributed in 4 phenotypesand the most prevalent phenotype was phenotype D, 40.63%followed by 32.50% phenotype A and 14.38% phenotype C.Mean age of overall women was 24.94±4.86. In this studyoverall prevalence of metabolic syndrome was 37.5%. Almost50% women of phenotype A had metabolic syndrome followedby 35% of phenotype B, 34.78% of phenotype C and leastprevalence was in phenotype D 30.77%.Conclusion: We concluded that the most prevalent phenotypeis nonhyperandrogenic phenotype 40.63% and least commonphenotype is classic nonpolycystic ovaries phenotype(12.50%).
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    Disseminated histoplasmosis in an immunocompetent individual--a case report.
    (2005-04-09) Sharma, Seema; Kumari, Niraj; Ghosh, Parasar; Aggarwal, Amita
    We report a rare case of disseminated histoplasmosis in a immunocompetent young adult person involving bone marrow, liver, spleen and oral cavity. He presented with oral ulcers, weight loss and pancytopenia. His bone marrow aspiration examination revealed Histoplasma capsulatum.
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    Effect of a Quality Improvement Package on Reducing Newborn Mortality from 26 to 14 in a Himalayan North Indian State
    (Wolters Kluwer – Medknow, 2022-06) Sharma, Seema; Sood, Mangla; Sharma, Kavya; Sood, Ishaan
    Background: In India, newborn mortality remains high due to a number of factors, including poor quality of care at health facilities. The experience of executing complete neonatal care quality improvement (QI) package at selected hospitals in Himachal Pradesh and reduction in newborn mortality rate (NMR) is described in this study. Objective: The short-term objective was the participants’ retention of knowledge and skills, and the achievement of uniform QI objectives following training and after a minimum of 6 months. Overall reduction in NMR was long-term objective. Methods: Newborn care QI package was implemented according to India Newborn Action Plan over a period of 48 months from 2013 to 2016, through infrastructure, trainings, and supportive supervision. Results: Total 13 health facilities were upgraded; 350 staff nurses and medical officers were trained. The mean posttraining knowledge score was 75% compared to 29% in the pretraining test, and 63% 1 year later. The competencies of health workers in the care of high?risk babies and 12 QI targets had improved, resulting in a 46% reduction in neonatal mortality in the state across all gestations and weights based on sample registration survey. Conclusion: Implementation of a bundle of evidence-based practices in low-resource setting for health system strengthening for intrapartum and neonatal care was linked to changed care behaviors among health-care providers, and reduction in NMR.
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    Effect of glimepiride compared with glibenclamide on post prandial blood sugar in type II diabetes mellitus patients.
    (2014-01) Rani, Meenu; Yadav, Shailesh; Choudhary, Seema; Sharma, Seema; Pandey, Surya Mani
    Background: Diabetes mellitus is a major public health problem with many complications. The Global Burden of Diabetes Study has projected that there will be a 122% increase in the number of people with diabetes mellitus worldwide in 2025 compared to 1995. Despite the availability of new agents for the treatment of type 2 diabetes mellitus oral sulfonylureas remain a cornerstone of therapy. Glibenclamide and glimepiride are widely used sulfonylurea antidiabetic drugs. Methods: A randomized, open, parallel group study was conducted by the Department of Pharmacology in association with Department of Medicine at Maharishi Markandeshwar Institute of Medical Sciences & Research (MMIMSR), Mullana, Ambala. Total 50 patients were divided into two groups I & II. In Group I (n=25) glibenclamide (5-15 mg/day) & in Group II (n=25) glimepiride (1-6mg/day) was administered for a period of 24 weeks and data analyzed by Student’s “t”- test. Results: There was a significant improvement in the post prandial blood sugar score (p<0.05) in both the study groups (I&II) after 24 weeks but post prandial blood level did not differ significantly (p>0.05) between the two groups. Conclusions: Both the drugs glibenclamide and glimepiride were effectively reduced post prandial blood sugar in both the groups. But these sulfonylurea drugs lowered post prandial blood sugar to a similar degree without significant difference between the two groups.
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    A histopathological study of hysterectomy specimens and their clinical correlation in patients at tertiary health care setup in Bundelkhand region of Uttar Pradesh
    (Medip Academy, 2023-08) Agarwal, Sippy; Sharma, Seema; Pandey, Divya
    Background: Women in their life time are prone to develop several neoplastic and non-neoplastic lesions in her uterus and cervix basically due to hormone responsiveness of female genital tract system. The aim of the study was to evaluate all hysterectomy specimens and to study the pattern of pathological changes of different lesions occurring in cervix and uterus associated with different age groups.Methods: This retrospective cross-sectional, study was conducted on patients undergoing hysterectomy in department of obstetrics and gynecology in MLB Medical College Jhansi and hysterectomized specimens reported to department of pathology for further evaluation. Total 35 hysterectomy specimens were included in the study with age of patients varying from 30 years to 60 years. Detailed clinical and other relevant history were taken followed by thorough gross examination and histopathological evaluation.Results: Majority of hysterectomy specimens were sent for histopathological examination in the department of pathology, out of these 30 (85%) were total abdominal hysterectomy specimen, 5 (14.28%) were of vaginal hysterectomy specimens. Out of all these cases, in 7 (20%) cases bilateral or unilateral salpingopherectomy done.Conclusions: In our study, most common surgical procedure for hysterectomy was abdominal hysterectomy 30 (85.7%) followed vaginal hysterectomy 5 (14.28%) All the vaginal hysterectomy was done for second- and third-degree utero-vaginal prolapse. Most prevalent endometrial histopathological finding in our study is non-secretive 15 (42.8%), secretive 7 (20%) followed by atrophic 6 (17.1%) as most of the patients in our study presents with abnormal uterine bleeding and menorrhagia 23 (65.7%).
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    A histopathological study of hysterectomy specimens and their clinical correlation in patients at tertiary health care setup in Bundelkhand region of Uttar Pradesh
    (Medip Academy, 2023-08) Agarwal, Sippy; Sharma, Seema; Pandey, Divya
    Background: Women in their life time are prone to develop several neoplastic and non-neoplastic lesions in her uterus and cervix basically due to hormone responsiveness of female genital tract system. The aim of the study was to evaluate all hysterectomy specimens and to study the pattern of pathological changes of different lesions occurring in cervix and uterus associated with different age groups.Methods: This retrospective cross-sectional, study was conducted on patients undergoing hysterectomy in department of obstetrics and gynecology in MLB Medical College Jhansi and hysterectomized specimens reported to department of pathology for further evaluation. Total 35 hysterectomy specimens were included in the study with age of patients varying from 30 years to 60 years. Detailed clinical and other relevant history were taken followed by thorough gross examination and histopathological evaluation.Results: Majority of hysterectomy specimens were sent for histopathological examination in the department of pathology, out of these 30 (85%) were total abdominal hysterectomy specimen, 5 (14.28%) were of vaginal hysterectomy specimens. Out of all these cases, in 7 (20%) cases bilateral or unilateral salpingopherectomy done.Conclusions: In our study, most common surgical procedure for hysterectomy was abdominal hysterectomy 30 (85.7%) followed vaginal hysterectomy 5 (14.28%) All the vaginal hysterectomy was done for second- and third-degree utero-vaginal prolapse. Most prevalent endometrial histopathological finding in our study is non-secretive 15 (42.8%), secretive 7 (20%) followed by atrophic 6 (17.1%) as most of the patients in our study presents with abnormal uterine bleeding and menorrhagia 23 (65.7%).
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    Implantation Rates after Two and Five Days of Embryo Culture: A Comparative Study.
    (2013-10) Kaur, Prabhleen; Swarankar, M L; Maheshwari, Manju; Sharma, Seema
    The aim of our study was to compare the Implantation rates of embryos transferred after two and five days of culture. A Randomized, prospective study was conducted in Infertility clinic, Department of Obstetrics & Gynecology,Mahatma Gandhi Hospital, Jaipur on 300 patients aged 25-40 years undergoing in-vitro fertilization (IVF)/ intra-cytoplasmic sperm injection (ICSI) cycle from May 2010-April 2011. When three or more Grade-I embryos were observed on day 2 of culture, patients were divided randomly into two study groups, day 3 transfer group and blastocyst transfer group or day 5 transfer group having 150 patients each. IVF outcome in terms of Implantation rate was compared between the groups. The results were analyzed using proportions, standard deviation and chi-square test.Both the groups were similar for age, indication and number of embryos transferred. Embryo transfers on day 5 resulted in significantly higher ongoing pregnancy and implantation rates as compared with day 3 embryo transfers(44% and 35.17% versus 29.33% and 21.35%, respectively)(P< 0.001). No significant difference was found in terms of multiple gestations in both the groups. Embryo transfers on day 5 of culture give significantly higher chance of ongoing pregnancy and implantation rates per cycle and per transfer than day 3 transfers.
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    Implantation Rates after Two and Five Days of Embryo Culture: A Comparative Study.
    (2014-01) Kaur, Prabhleen; Swarankar, M L; Maheshwari, Manju; Sharma, Seema
    The aim of our study was to compare the Implantation rates of embryos transferred after two and five days of culture. A Randomized, prospective study was conducted in Infertility clinic, Department of Obstetrics & Gynecology,Mahatma Gandhi Hospital, Jaipur on 300 patients aged 25-40 years undergoing in-vitro fertilization (IVF)/ intra-cytoplasmic sperm injection (ICSI) cycle from May 2010-April 2011. When three or more Grade-I embryos were observed on day 2 of culture, patients were divided randomly into two study groups, day 3 transfer group and blastocyst transfer group or day 5 transfer group having 150 patients each. IVF outcome in terms of Implantation rate was compared between the groups. The results were analyzed using proportions, standard deviation and chi-square test.Both the groups were similar for age, indication and number of embryos transferred. Embryo transfers on day 5 resulted in significantly higher ongoing pregnancy and implantation rates as compared with day 3 embryo transfers(44% and 35.17% versus 29.33% and 21.35%, respectively)(P< 0.001). No significant difference was found in terms of multiple gestations in both the groups. Embryo transfers on day 5 of culture give significantly higher chance of ongoing pregnancy and implantation rates per cycle and per transfer than day 3 transfers.
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    Improving the Breastfeeding Practices in Healthy Neonates During Hospital Stay Using Quality Improvement Methodology
    (Indian Academy of Pediatrics, 2018-09) Sharma, Seema; Sharma, Chanderdeep; Kumar, Dinesh
    Objective: To demonstrate the applications of the principles ofQuality Improvement (QI) in a tertiary-care centre with the aim toimprove the breastfeeding practices during hospital stay.Methods: An operational team was formulated to identify thereasons for low proportion of exclusive breast feeding (EBF) inhealthy neonates. Reason specific solutions were proposed,discussed, prioritized and tested using Plan-Do-Study-Act Cycle(PDSA Cycle). Strategies included clear departmental policy planand creation of Breastfeeding support package (BFSP). PDSAcycles were tested and implemented over 6 weeks period and itssustainability was measured monthly for five months duration.Results: After implementation of PDSA cycles, the proportion ofneonates receiving early breastfeeding within one hour of birthincreased from 55% to 95%, and the proportion of neonates onEBF during hospital stay increased from 72% to 98%.Conclusion: Quality Improvement principles are feasible andeffective to improve breastfeeding practices in the hospitalsetting.
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    Knowledge of Accredited Social Health Activist (ASHA) Workers Regarding Maternal Health Services: A Comparative Study between Rural and Urban Areas of a Block of Haryana
    (Indian Association of Preventive and Social Medicine (IAPSM), 2022-12) Sharma, Seema; Kumar, Amit; Kansal, Divyae; Kumari, Sneh; Pandey, S M
    Introduction: All people, everywhere, deserve the right care, right in their community. In any community, maternal mortality ratio strongly reflects the overall effectiveness of health systems. To increase utilization of existing health services, Accredited Social Health Activist (ASHA) is the key component of the National Rural Health Mission. o assess compare the level of knowledgeO : bjective T any of ASHA workers regarding maternal health services in between rural and urban areas of a block of Haryana. Method: The present cross-sectional, community-based study was conducted in block Barwala, district Hisar of Haryana. The assessment of knowledge of ASHA workers was done on the basis of scoring. Appropriate statistical tests like percentages and chi-square (?2) test were applied. RegardingResult :s maternal health services majority of ASHA workers had good knowledge, assessed by score gained by them and none of them was having poor knowledge about maternal health services. However in rural area score, gained was better than urban area & the observed difference was found to be statistically significant. Knowledge of identification & treatment of anaemia and identification of danger signs during pregnancy were inadequate among ASHA workers of both areas. Knowledge of ASHA workers wasConclusion: inadequate as far as anaemia and danger signs during pregnancy were concerned. Frequent and regular refresher training should be organized in their working area.
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    Lymphoid aggregates in bone marrow biopsies in patients with hypereosinophilia.
    (2008-07-30) Sharma, Seema; Dhameja, Neeraj
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    Microfilariae in bone marrow aspirate of a case of myelofibrosis: A cause or coincidence?
    (Wolters Kluwer India Pvt. Ltd., 2020-04) Khaliqur, Rahman; Shivangi, Harankhedkar; Gupta, Ruchi; Gupta, Tanvi; Sharma, Seema; Nityanand, Soniya
    Filariasis is among the common parasitic infestations found in India, with Wuchereria bancrofti being the most common causative organism. Presentation ranges from clinically asymptomatic to profound elephantiasis. It is also detected incidentally in diagnostic samples such as body fluids, fine needle aspirates, peripheral blood smears, and other cytological smears. Its detection in bone marrow aspirates with an associated hematolymphoid neoplasm is rare, with only a few case reports. We report one such case of young male who presented with leukocytosis of 253 × 109/L with basophilia and massive splenomegaly. Bone marrow aspirate smears showed the presence of microfilariae along with other features of a myeloproliferative neoplasm (MPN). The present case is probably the first case of finding a microfilaria in a case of MPN
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    Microfilariae in bone marrow aspiration smears, correlation with marrow hypoplasia: a report of six cases.
    (2006-10-23) Sharma, Seema; Rawat, Amit; Chowhan, Amit
    Microfilariae have been reported in various cytological preparations, however there are very few case reports describing microfilariae in bone marrow aspirates. We report six such cases with the interesting finding of marrow hypoplasia in five of these cases.