Browsing by Author "Sharma, Ashok K"

Now showing 1 - 11 of 11
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    Corneo- Conjunctival Auto Grafting in Pterygium Surgery
    (2004-07) Sharma, Ashok K; Wali, Vijaya; Pandita, Archana
    To evaluate the efficacy of conjunctival auto grafting in surgical management of primary and recurrent pterygium, the record of 150 patients comprising 47 females and 103 males who underwent corneocunjunctival auto graft transplant surgery for primary and recurrent pterygia from 1997 to 2003 was reviewed retrospectively. Follow up was done for six months after the surgery. Recurrence of pterygium was considered as failure. All grafts were transplanted promptly. Recurrence was noted in four patients (2.6%). Mild discomfort in the immediate post-operative period was noted in all the patients. Donor site healed without any complication in all the patients.The results indicate that corneo-conjunctival autograft transplantation is an effective treatment for management of both primary & recurrent pterygia.
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    E-Learning Versus Traditional Teaching in Medical Education: A Comparative Study
    (JK Science, 2020-10) Sharma, Ashok K; Sharma, Hans Raj; Choudhary, Uzma
    Background: Traditional method of learning via face to face lecture has been in curriculum since timesimmemorial. E-learning via multimedia has been a recent introduction in education system. Purpose: Tocompare e-learning with the traditional method of teaching in medical education. Material and Methods: Thetwo different methods of teaching were applied on the same group of students. A total of six lectures wereconducted. Three of them were taught by traditional method of teaching and three by e-leaning. Formativeassessment in the form of written examination was carried out, followed by qualitative assessment at the endof session. Results: The mean marks obtained after Exam-1 (i.e. following traditional teaching method) was6.46 ± 1.48 and mean marks obtained after Exam-2 (i.e. following e-learning) was 8.37 ± 1.27. The meandifference score was 1.91 ± 1.55. The paired t-test was applied, and the value of t was 11.96 with p-value<0.001. The results between two teaching methods were statistically significant. For qualitative analysisLikert scale was used. 66% of students strongly agreed that e-learning is a superior method than traditionalmethod of learning. Conclusion: The e-learning proved to be more efficient and uniform method of studentlearning with revision facilities.
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    Effect of Inula racemosa root extract on cardiac function and oxidative stress against isoproterenol-induced myocardial infarction.
    (2011-02) Ojha, Shreesh; Bharti, Saurabh; Sharma, Ashok K; Rani, Neha; Bhatia, Jagriti; Kumari, Santosh; Arya, Dharamvir Singh
    The cardioprotective potential of Inula racemosa root hydroalcoholic extract against isoproterenol-induced myocardial infarction was investigated in rats. The rats treated with isoproterenol (85 mg/kg, s.c.) exhibited myocardial infarction, as evidenced by significant (P<0.05) decrease in mean arterial pressure, heart rate, contractility, relaxation along with increased left ventricular end diastolic pressure, as well as decreased endogenous myocardial enzymatic and non-enzymatic antioxidants. Isoproterenol also significantly (P<0.05) induced lipid peroxidation and increased leakage of myocyte injury marker enzymes. Pretreatment with I. racemosa extract (50, 100 or 200 mg/kg per day, p.o.) for 21 consecutive days, followed by isoproterenol injections on days 19th and 20th significantly (P<0.05) improved cardiac function by increasing the heart rate, mean arterial pressure, contractility and relaxation along with decreasing left ventricular end diastolic pressure. Pretreatment with I. racemosa also significantly (P<0.05) restored the reduced form of glutathione and endogenous antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase from the heart, which were depleted after isoproterenol administration. In addition to restoration of antioxidants, I. racemosa significantly (P<0.05) inhibited lipid peroxidation and prevented the leakage of myocytes specific marker enzymes creatine phosphokinase-MB and lactate dehydrogenase from the heart. Thus, it is concluded that I. racemosa protects heart from isoproterenol-induced myocardial injury by reducing oxidative stress and modulating hemodynamic and ventricular functions of the heart. Present study findings demonstrate the cardioprotective effect of I. racemosa and support the pharmacological relevance of its use and cardioprotection mechanism in ischemic heart disease as well as substantiate its traditional claim
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    Effects of calcium channel blocker, nifedipine, on antidepressant activity of fl uvoxamine, venlafaxine and tianeptine in mice.
    (2015-01) Sharma, Ashok K; Khadka, Anjan; Dahiya, Navdeep
    Background: Cardiovascular diseases are commonly associated with depression. Calcium channel blockers (CCBs) form commonly used group of drugs for the treatment of a number of cardiovascular diseases. Nifedipine, a CCB, has been shown to possess antidepressant activity and potentiate antidepressant activity of imipramine and sertraline, however, literature on its interaction with newer antidepressant drugs such as fl uvoxamine, venlafaxine and tianeptine is limited. Hence, the present study was undertaken. Methods: The study was carried out in albino mice in two phases. In Phase I, antidepressant activity of nifedipine, fl uvoxamine, venlafaxine and tianeptine were confi rmed after their single dose administration using forced swim test (FST) and tail suspension test (TST) and their minimum antidepressant doses were determined. In Phase II, the effect of nifedipine on antidepressant activity of fl uvoxamine, venlafaxine and tianeptine was studied by orally administering sub-antidepressant doses of these drugs for 28 days. FST and TST were carried out on 1st, 14th and 28th day of the study and change in immobility period was observed. Results: In Phase I, all the studied drugs exhibited dose dependent antidepressant activity in both FST and TST. Minimal antidepressant dose of nifedipine, fl uvoxamine, venlafaxine and tianeptine was observed as 10, 25, 25 and 10 mg/kg respectively. In Phase II, combinations of sub-antidepressant dose of nifedipine (5 mg/kg) with sub-antidepressant doses of fl uvoxamine (12.5 mg/kg), venlafaxine (12.5 mg/kg) and tianeptine (5 mg/kg) exhibited enhanced antidepressant activity when compared to the control group and individual drug groups after same duration of treatment. Conclusions: Nifedipine, fluvoxamine, venlafaxine and tianeptine possess antidepressant activity and nifedipine exhibits synergistic antidepressant activity with fl uvoxamine, venlafaxine and tianeptine.
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    Gamma Linolenic Acid in Dry Eye
    (2006-01) Sharma, Ashok K; Raj, Hans; Pandita, Archana; Tandon, Vishal R; Mahajan, Annil
    In this prospective study to evaluate the role of gamma linolenic acid in the management of dry eye, 100 patients of dry eyes were studied by dividing randomly into two groups of 50 each. In the test group, all the 50 patients were put on medication which consisted of cap gamma linolenic acid - 120 mg once daily dose, artificial tears solution/ointments 4-6 times daily with a topical mild steroid (loteprednol etabonate 0.5%) thrice daily. In the control group all the 50 patients were put on artificial tear solution/ointments and topical mild steroid (loteprednol etabonate 0.5%) thrice daily. All the patients were subjected to slit lamp examination, schirmer test, and fluorescien stain for tear film break up time (TBUT). In the test group symptomatic relief was shown by all 50 (100%) patients after one week of treatment. There was not much improvement in the schirmer test and TBUT results at 1 week. At 1 month follow up the result showed improvement and at 6 months there was definite increase in the schirmer test & TBUT values. The results were not influenced by the age & gender of the patients. In the control group though there was definite symptomatic relief in all the patients, but there was no change in the major study parameters i.e. tear film meniscus height; schirmer test and TBUT. At six month of the study there was marginal improvement of the major parameters but there was a lot of difference between the test and control groups. Thus gamma linolenic acid has a definite role in the management of dry eye.
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    Late omental gangrene following corrosive ingestion.
    (2011-04) Nayeem, Mohammed; Saluja, Sundeep S; Sharma, Ashok K; Saran, Ravindra K; Mishra, Pramod K
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    Psycho- Social Adjustments and Rehabilitation of The Blind.
    (2008-01) Bhagotra, Sudhir; Sharma, Ashok K; Raina, Bhavna
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    Reversible Blindness in Severe Preeclampsia and Eclampsia
    (2004-01) Jyotsana; Sharma, Ashok K; Bhatt, Sunil
    Visual disturbances are common with severe preeclampsia, however, blindness either alone or accompanying convulsions is uncommon. Most women with varying degree of amaurosis are found to have radiographic evidence of extensive occipital lobe hypodensities.In this case report, we present the clinical course of two women in whom preeclampsia was further complicated by blindness. These were managed by standard pre eclampsia- eclampsia regimen used at our hospital which includes Diazepam /Phenytoin therapy to control seizures, nifedipine to lower elevated blood pressure, intravenous fluid restriction and termination of pregnancy. Abnormal findings in these women were seen by computed tomography and magnetic resonance imaging technique. CT demonstrated low density areas localized predominantly in occipital area. Blindness persisted from 24 hrs to 72 hrs, it subsequently resolved completely in both.
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    Squamous Cell Carcinoma of the Conjunctiva
    (2002-01) Sharma, Ashok K; Bhardwaj, Subhash
    A rare case of squamous cell carcinoma of the conjunctiva is presented here. This highlights the significance of aggressive management of such cases surgically and the use of adjuants per operatively to prevent recurrence.
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    Sympathetic Ophthalmia: Mangement and Role of Immunosuppressants.
    (2000-04) Kapoor, R.; Sharma, Ashok K; Bhardwaj, Subhash
    Presented here is a case of sympathetic ophthalmia that provided us an opportunity to evaluate the eficacay of immunosuppressive drugs with steroids in reduced doses and their outcome in improving thevisual loss in a young patient who had fast deterioration in his visual acuity.
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    The Transplantation of Human Organs Act
    (2001-01) Sharma, Ashok K; Bhagotra, Sudhir K; Nanda, Dheeraj