Browsing by Author "Sengupta, D"
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Item Abnormal glucose tolerance test after acute myocardial infarction in higher income group patients. A study of 120 cases.(1968-01-01) Lal, H B; Caroli, R K; Behl, A N; Sengupta, DItem Age related changes of gluconeogenic activity in human placenta during foetal development.(1986-10-01) Sengupta, T; Datta, C; Dasgupta, J; Sengupta, DItem Age-related changes of glycogen metabolism in human fetal heart.(1989-04-01) Dasgupta, J; Datta, C; Sengupta, T; De, S; Sengupta, DThe changes in the activities of three important glycogen metabolising enzymes, viz. glycogen synthetase, glycogen phosphorylase and alpha-D-glucosidase, along with glycogen content have been measured in adult human heart and human fetal heart collected at 13-36 weeks of gestation. At an early period, particularly 13-16 weeks of gestational age, the activity of glycogen synthetase and glycogen content were found to be maximum. However the activity of glycogen phosphorylase remained constant throughout the gestation and that of alpha-D-glucosidase showed a peak at 25-28 weeks of gestation, thereby indicating that fetal heart tissue has the capacity to utilise glycogen for energy.Item AIDS in India: recent trends in opportunistic infections.(1998-06-14) Misra, S N; Sengupta, D; Satpathy, S KThe first case of AIDS in India was reported in 1986. Subsequently, a surveillance system was developed in 1987. The data from this surveillance activity suggest that the HIV infection has now spread to the general population and to all parts of the country, except Arunachal Pradesh in North-eastern India. With the changing scenario of the AIDS epidemic, a host of opportunistic infections add to the present endemic state of some already existing infections like tuberculosis. This report analyses the AIDS cases in India, reported to the National AIDS Control Organization over the years between 1986 to 1997. A total of 3,551 AIDS cases had been reported till 31st May 1997. Tuberculosis (pulmonary and extrapulmonary) is the major opportunistic infection affecting 62% of the cases followed by candidiasis seen in 57% of the patients. In 1997, of the 390 AIDS cases analysed, tuberculosis (pulmonary and extrapulmonary) accounted for 56.5% of the total cases whereas candidiasis was seen in 61% of the cases. An increasing trend was observed with tuberculosis from 58% in 1986-1992 to 68.5% in 1995. No trend could be established in the case of candidiasis, though, a high prevalence of 66% was seen in the cases between 1986 and 1992. An increase was also observed in cases of PCP, cerebral toxoplasmosis and Kaposi sarcoma. In the AIDS cases, chronic diarrhea (76%), weight loss (87%) and fever (85%) appeared to be the major presenting symptoms. But, of the 390 AIDS cases reported in 1997, only 47% of them were suffering from chronic diarrhea. With increase in the number of AIDS cases, India is burdened with a dual epidemic of HIV/AIDS and tuberculosis. The National AIDS Control Organization in India, is involved in training clinicians and laboratory personnel in the diagnosis and management of the AIDS cases. With better diagnosis of the opportunistic infections, especially diarrhea, in AIDS patients, a better picture will emerge regarding the opportunistic infections which would help clinicians and health planners to tackle the AIDS epidemic in a more effective manner.Item AIDS-case surveillance.(1994-01-01) Lal, S; Khodakevich, L; Sengupta, DItem Alternative pathway of glucose metabolism in developing human foetal heart.(1985-12-01) Dasgupta, J; Sengupta, T; Datta, C; De, K; Saha, U; Sengupta, DItem Amoebic abscess of the spleen.(1975-01-16) Sengupta, D; Mukherjee, BItem Biochemical effect of non-antiovulatory doses of different progestins on cycling rat uterus.(1980-04-01) Guin, A K; Das, S; Datta, S C; Dey, S; Sengupta, DItem Biochemical profile of erythrocyte membrane of jaundiced neonates.(2000-01-10) Mazumder, S; Sarkar, U; Sengupta, DStudies in newborn humans have demonstrated alteration in the lipid, phospholipid and cholesterol content when compared with age-matched control. Membrane bound (Na+ + K+)ATPase activity is found to be significantly increased in jaundiced neonates. Alteration in membrane permeability characteristics in jaundiced neonates causes severe microenvironmental changes in red blood cell profile.Item Biochemical studies on the in vitro effect of doxepin on Mg2+ & Na+, K+)-ATPases of human foetal & adult brain.(1989-02-01) Saha, U K; Sengupta, T; Sirkar, A; Sengupta, DThe in vitro effect of doxepin at 10, 50 and 200 micrograms/mg protein on Mg2+ and (Na+ K+)-ATPases (EC 3.6.1.3) activities of human foetal and adult brain (crude homogenate of cerebrum and cerebellum) were studied at 10-30 wk of gestation. Both Mg2+ and (Na+, K+)-ATPases of human foetal and adult brain were found to be inhibited by doxepin in a dose dependent manner. The inhibitory effect neither varied with respect to the region (i.e., cerebrum and cerebellum) nor with the gestational ages. Inhibition of ATPases activity by doxepin may affect the release and uptake of biogenic amines in the CNS, which may hamper the maturation of brain.Item Chromoblastomycosis.(1975-06-16) Mukherjee, B; Sengupta, D; Bhattacharyya, K KItem Developmental changes of TCA cycle enzymes in human fetal brain.(1988-10-01) Sengupta, T; Dutta, C; Dasgupta, J; Sengupta, DItem Developmental changes of the glycolytic enzymes in the human fetal heart.(1985-12) Gupta, Jayati Das; Sengupta, Trishna; Dutta, Chhabi; De, Kathakali; Sengupta, DThe ontogeny of hexokinase, phosphofructokinase, phosphoglucoisornerase, aldolase, pyruvate kinase and lactate dehydrogenase activities which are associated with glycolysis, an important energy yielding process, has been studied in human fetal heart for periods ranging from 13 weeks to above 33 weeks of gestation. Hexokinase, phosphoglucoisomerase and pyruvate kinase activities show similar developmental profiles exhibiting maximum activity at 25-28 weeks ofgestation. Phosphofructokinase activity, on the other hand, shows a minimum at this period and exhibits a peak value at early stages (13-16 weeks of gestation). Though considerable activity for aldolase is observed at an early period, it declines thereafter, but again increases in the later period. The probable role and correlations of these glycolytic enzymes with energy demand and general functional development in human fetal heart in ontogeny are evaluated.Item Developmental pattern of enzymes related to glycolysis in human foetal brain.(1987-09-01) Sengupta, T; Dasgupta, J; Datta, C; Sengupta, DItem Diagnosis and management of opportunistic infections in childhood AIDS.(1994-09-01) Lal, S; Sengupta, DItem Effect of delta-9 tetrahydrocannabinol on rat intestinal ATPases.(1977-03-01) Sengupta, D; Chakravorty, I; Datta, S C; Ghosh, J JItem Effect of different antiestrogen on glycogen breakdown of cycling rat uterus during estrous & proestrous phases.(1978-08-01) Guin, A K; Dutta, P K; Datta, S C; Das, S; Sengupta, DItem Effect of excess methionine administration on protein synthesis in developing rat brain.(1975-05-01) Sarkar, D; Sengupta, D; Ghosh, J JItem Effect of malathion on antioxidant defence system in human fetus--an in vitro study.(1992-04-01) Gupta, J; Datta, C; Sarkar, A; Sengupta, DMalathion under in vitro condition even at lower concentration (250 ppm) altered the level of enzymes associated with glutathione cycle and antioxidant defence system in human fetal brain and liver. Such changes involved alterations in glutathione status and extent of lipid peroxidation. The inhibitory effect of malathion was dose dependent in case of human fetal brain and was more vulnerable than fetal liver. This alteration (inhibition or activation) was maximum in case of tissues from fetuses of early period of development, suggesting greater susceptibility of human fetus towards this organophosphorus insecticide.Item Effect of non-antiovulatory doses of norethindrone & depoprovera on implantation in rat.(1980-08-01) Guin, A K; Datta, S C; Das, S; Sengupta, D
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