Browsing by Author "Sendhilvadivu, M."

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    Ameliorative extract Syzygium cumini seed extract on lipid peroxidation and antioxidant activity in alloxan induced diabetic Wistar albino rats
    (Triveni Enterprises, 2024-09) Kavitha, E.; Sendhilvadivu, M.
    Aim: This study intends to examine the protective effects of an aqueous extract of Syzygium cumini seed on lipid peroxidation and antioxidant enzyme activities in alloxan-induced diabetic Wistar albino rats. Methodology: A single intraperitoneal injection of 150 mg kg-1 b.wt of alloxan monohydrate was used to induce diabetes in rats. Syzygium cumini group rats were later administered 300 mg kg-1 of Syzygium cumini seed extract by oral gavage for 21 days. On 22nd day, the animals were given general anaesthesia, blood was drawn through the retroorbital plexus, and the kidneys were promptly removed. Lipid peroxidation levels were assessed in the blood (serum) and kidney tissues by measuring the thiobarbituric acid reactive substances, and the activities of antioxidant enzymes such as GST, GPX, SOD and CAT were examined in the blood and kidneys. Results: The acute toxicity experiments revealed that Syzygium cumini did not cause any obvious toxicity indications or mortality at a dosage of 300 mg kg-1, proving the safety of this extract with a broad therapeutic index. The results obtained showed that using aqueous Syzygium cumini seed extract for 21 days considerably (P <0.05) increased the antioxidant enzyme activity for GST, GPx, SOD and CAT, while significantly (P <0.01) decreasing the TBARS levels. Interpretation: Conclusively, the seed extract of Syzygium cumini might be a possible treatment for controlling hyperglycemic oxidative stress complications owing to its antioxidant properties.
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    Hepatoprotective effect of Cassia auriculata extract against ethanol-induced oxidative stress in Wistar albino rats
    (Triveni Enterprises, 2024-03) Aarthi, B.L.; Sendhilvadivu, M.
    Aim: To investigate the potential hepato-protective effect of Cassia auriculata leaf extract against ethanol-induced oxidative stress in albino rats, by exploring the antioxidant properties of Cassia auriculata and its ability to mitigate oxidative damage caused by ethanol consumption, and the underlying mechanisms involved. Methodology: In the present study, Group – I served as Control, Group – II (Ethanol induced group), where 50% ethanol was orally administered to the rats, Group – III (treatment group), where 250 mg kg-1 of Cassia auriculata leaf extract was orally administered to the hepato-toxic albino rats and in Group – IV, rats were treated with standard reference drug Silymarin (100 mg kg-1) followed by estimating the parameters related to oxidative stress such as TBARS and antioxidants enzyme levels such as GST, GPx, SOD and CAT in the blood and liver tissue samples. Phytochemical analysis of Cassia auriculata leaf powder was conducted to determine the active phytoconstituents. Results: Treatment with Cassia auriculata extract significantly (p<0.001) reduced the damage caused by oxidative stress by decreasing the levels of TBARS and significantly (p<0.001) elevated the levels of antioxidant enzymes such as GST, GPx, SOD and CAT in the serum and liver samples. Interpretation: The present study provides an opportunity to explore the potential therapeutic properties of Cassia auriculata in combating ethanol-induced oxidative stress.