Browsing by Author "Sen, P C"
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Item Accumulation of serotonin in human cerebral contusion.(1978-06-01) Mohanty, S; Dey, P K; Sen, P C; Ray, AItem Antinuclear antibodies in primary glaucoma and endogenous anterior uveitis.(1982-07-01) Singh, R; Saxena, D N; Singh, V P; Sen, P CItem Antitoxoplasma antibody in clinically suspected cases of human toxoplasmosis.(1990-04-01) Kar, S; Sen, M R; Gangopadhyay, A N; Sen, P C(1) Seventy sera from a variety of patients suffering from different diseases suspected to be caused by Toxoplasma gondii infection and forty from non-toxoplasmic hospital cases and laboratory and hospital staff were collected. (2) Antitoxoplasma antibody was detected in those sera by Indirect Haemagglutination test (IHA test) and Enzyme Linked Immunosorbent Assay (ELISA). (3) Twenty one (30%) sera out of 70 test samples and 2 (5%) out of 40 control samples were positive by ELISA test. With IHA test only 17 (24.3%) of test samples and same 2 (5%) of control samples were positive. (4) Sera collected from Paediatric Department showed the highest positivity (40%) followed by Opthalmological group (35.7%) and obstetrics and Gynaecological group (13.6%). (5) No significant co-relation was found between the seropositivity with sex, diet and history of cat contact of the patients.Item Bacteriological study of Ganges water at Varanasi.(1976-03-01) Agarwal, D K; Gaur, S D; Sen, P C; Marwah, S MItem Cell mediated immunity in liver diseases.(1979-04-01) Bajpai, H S; Sen, P C; Joseph, J K; Agrawal, J KItem Cell mediated immunity in tuberculoid leprosy--a study of 'T' lymphocyte population by 'E' rosetty technique.(1986-04-01) Behra, R N; Sen, P C; Sharma, B N; Rajendran, PItem Cellular immunity status in anaemia in pregnancy.(1991-02-01) Kandoi, A; Bhatia, B D; Pandey, L K; Pandey, S; Sen, P C; Satya, KFifty pregnant women (25 anaemic and 25 non-anaemic) and 20 non pregnant women (10 anaemic and 10 non-anaemic) were studied. All pregnant women delivered full term (37-41 wk) singleton babies. Maternal blood lymphocyte stimulation indices (SI) at 0 and 24 h were lower in anaemic and non-anaemic pregnant women, compared to anaemic and non-anaemic non-pregnant women. This difference was more marked in anaemic pregnant women, as compared to non pregnant anaemic women at 0 and 24 h respectively. The SI of maternal and cord blood lymphocytes were significantly lower in severely anaemic mothers both at 0 and 24 h and in those with maternal serum iron levels below 50 micrograms/dl or maternal per cent transferrin saturation was below 15 per cent. The anaemic mothers and their offspring were found to have significantly lower blastogenic response to PHA added at 24 h indicating depression of T-suppressor cell function.Item Changes in lipid composition and some biologically important enzyme activities in the microsomal membranes of developing toad ovary in different seasons.(1989-06-01) Mukherjee, S; Sen, P CThe microsomal membranes isolated by sucrose density gradient centrifugation from developing toad ovary have been found to differ significantly in lipid composition and various enzyme activities in different seasons. All the enzymes studied, viz. Na+, K(+)-ATPase, delta 5-3 beta-hydroxysteroid dehydrogenase (delta 5-3 beta HSD) and prostaglandin synthetase, exhibited maximum activity during the breeding season (July-September) at all stages of development (a,b,c & d). The activities of Na+, K(+)-ATPase and delta 5-3 beta HSD increased with development while that of prostaglandin synthetase followed the reverse order. The total phospholipid, cholesterol and fatty acid contents also varied with season and development. The increase in Na+, K(+)-ATPase and delta 5-3 beta HSD activities in the microsomal membranes of toad ovary at breeding season is accompanied with concomitant increase in phospholipid and unsaturated fatty acid contents at different stages in this season, thereby suggesting some correlation between them.Item Circulating immune complexes and complement in bancroftian filariasis.(1991-04-01) Nath, G; Mohapatra, T M; Sen, P CSixty filarial cases, 30 endemic normal individuals and 10 non endemic subjects were investigated for the presence of Circulating Immune Complexes (CICs) and Complement Component C3. Using Polyethylene Glycol precipitation and Polyethylene Glycol precipitation-Complement Consumption methods, it was observed that CICs were raised significantly in chronic lymphatic filariasis and Tropical Pulmonary Eosinophilia (TPE) groups. The results observed by both the techniques for detection of CICs were comparable. Low levels of C3 were detected in chronic lymphatic filariasis cases by single radial immunodiffusion method, suggesting the utilization of complement by immune complexes.Item Commonly available anti fungal ophthalmic drops.(1978-07-01) Mehra, K S; Sen, P CItem A comparative evaluation of levamisole in leprosy.(1985-01-01) Sharma, L; Thalliath, G H; Girgia, H S; Sen, P CNinety adult leprosy patients attending the skin outpatient department of Institute Hospital of Varanasi, India, were selected for the study. A group of thirty patients including 10 cases of lepromatous, 10 of borderline and 10 cases in reaction of which 5 were of type 1 and 5 of type II reaction were treated with levamisole and DDS. Levamisole was given in the doses of 150 mg. daily for three consecutive days which was repeated after every 12 days. The effects were compared with two similar groups receiving clofazimine plus DDS and DDS alone respectively for six months. It was observed that levamisole was useful in bringing down both the types of reactions in a period shorter than required by clofazimine. Clinical improvement in non-reaction cases was found to be similar in all the three groups. Minor side effects were also seen with levamisole and clofazimine in some cases.Item Demonstration of histamine receptors on the surface of Entamoeba histolytica.(1989-01-01) Khan, M A; Sen, P CHistamine receptors on the surface of E. histolytica could be demonstrated by histochemical method using three isolates of the protozoa grown and maintained in modified Boeck and Drbohlav's medium. Prior treatment of E. histolytica with cimetidine a H2 blocker, blocked the histamine uptake. Similar treatment with mepyramine maleate, a H1 blocker, did not prevent histamine uptake by the protozoa. It is postulated that E. histolytica has H2 receptors on its surface.Item E-rosetting cells in amoebic liver abscess.(1981-09-01) Acharya, D P; Sen, P CItem Effect of chlorpromazine and gossypol on Ca(2+)-ATPase activity in the microsomal membranes of rat testes.(1991-04-01) Mazumder, B; Sikdar, R; Sen, P CThe microsomal membranes isolated from rat testes have been found to contain a Mg(2+)-dependent and a Mg(2+)-independent Ca(2+)-ATPase. The enzyme activities were inhibited by two contraceptive drugs--gossypol and chlorpromazine. The inhibition by the former was affected by the presence of ligand(s) and not the substrate in the incubation medium, whereas ligand(s)/substrate did not affect the inhibition by chlorpromazine. This may be explained from the fact that the binding of chlorpromazine and ligand(s)/substrate to the enzyme are independent of each other whereas in case of gossypol the ligand(s) compete with the drug at the binding site of the enzyme.Item Effect of exogenous 5-hydroxytryptamine on pathogenicity of Entamoeba histolytica in experimental animals.(1989-08-01) Acharya, D P; Sen, M R; Sen, P CIn an effort to find out the mechanism(s) operative in enhancing the pathogenicity of E. histolytica in hosts under heat stress reported earlier, effect of 5-hydroxytryptamine (5-HT) on the virulence of the parasite was examined in just weaned Charles Foster strain of albino rats. Pathogenicity of 10 strains of E. histolytica, from various forms of intestinal amoebiasis, grown in modified Boeck and Drbohlav's medium was assessed by caecal scoring. Administration of 5-HT in infected animals significantly enhanced the pathogenicity of all the seven strains tested. Treatment of the host with the 5-HT precursor L-tryptophan also increased the caecal scores examined with three strains of E. histolytica. Prior blocking of tissue 5-HT receptors by administration of methysergide almost completely abolished the pathogenicity enhancing effect of 5-HT treatment. This suggested that 5-HT itself and not any of its metabolites was responsible for the observed increase in pathogenicity of E. histolytica on 5-HT treatment of the host.Item Effect of histamine and serotonin on phagocytic activity of Entamoeba histolytica.(1988-09-01) Khan, M A; Sen, P CItem Effect of lowering the peripheral level of 5-hydroxytryptamine in host on the virulence of Entamoeba histolytica.(1984-06-01) Ahmad, I; Sen, P C; Kulkarni, R B; Sen, M RItem Effect of stress on the pathogenicity of Entamoeba histolytica.(1984-03-01) Sen, M R; Acharya, D P; Sen, P CItem Enhancement of virulence of Entamoeba histolytica by histamine in vitro.(1990-04-01) Khan, M A; Sen, P C; Mishra, BThree isolates of E. histolytica isolated and maintained in modified Boeck and Drbohlav's medium and the axenic nonpathogenic strain NIH-200 maintained in Diamond's TPS-1 medium were used to assess the effect of histamine added to the cultures on their pathogenicity in just weaned rats of Charles Foster strain. Initially when the three polyxenic isolates were examined for their Pathogenicity after growing them with graded concentrations of histamine viz. M-2 through M-6 (log dilutions of the molar concentration of histamine dihydrochloride) the caecal scores were significantly enhanced in cultures grown with M-2 and M-3 concentrations. Subsequently NIH-200 strain was examined similarly after growing it with 20 micrograms/ml of histamine dihydrochloride through three generations. The Neal's caecal score of NIH-200 increased significantly stepwise up to second subculture and became stabilised at third generation with histamine.Item Enteric infections in Sunderpur slum area.(1972-07-01) Sanyal, S C; Gaur, S D; Shrivastava, D L; Sen, P C; Marwah, S M; Singh, H
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