Browsing by Author "Sawlani, KK"
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Item Assessment of drug prescribing pattern using world health organization indicators in a tertiary care teaching hospital(Indian Public Health Association, 2018-06) Hussain, S; Yadav, SS; Sawlani, KK; Khattri, SThis cross-sectional study was carried out to assess drug prescribing pattern at a tertiary care teaching medical institute. One thousand prescriptions were randomly collected and analyzed using the world health organization prescribing indicators. The average number of drugs per prescription was 2.91. The percentage of drugs prescribed by generic name, from the essential drug list (National) and as fixed dose combinations (FDCs) was 10.05%, 22.57%, and 49.22%, respectively. The total percentage of encounters with antibiotics, injectables, and FDCs was 19.70%, 2.20%, and 73.60%, respectively. The most common group of drug prescribed was gastrointestinal tract drugs (26.38%) followed by Vitamins and Minerals (23.12%), cardiovascular system drugs (11.56%) and antimicrobials (9.63%). The prescribing practices were not appropriate as they consist of polypharmacy, lesser prescription by generic name, and overprescription of FDCs. There is a need for improvement in the standards of prescribing patterns in many aspects.Item A Comprehensive Guide to Interpreting Quality of Life in Elderly patients with Controlled and Uncontrolled Diabetes(?Eldaghayes Publisher, 2024-12) Hussain, MS; Hussain, S; Jakhar, A; Usman, K; Sawlani, KK; Khattri, S.Background: Because old adults with type 2 diabetes are associated with an increase in mortality and complications when compared to young diabetics and non-diabetic people of the same age group, the elderly are at a high risk for this condition. Diabetes affected nearly 19 million people in 2010, accounting for 26.9% of all those in this age range. The most important factor in determining a person’s level of health is their quality of life (QOL). Aim and objectives: The aims of this study are to determine the QOL in controlled and uncontrolled geriatric type 2 diabetes mellitus patients receiving antidiabetic drug therapy using the World Health Organization Quality of Life— BREF (WHOQOL-BREF) and Appraisal of Diabetes Scale (ADS) questionnaire. Materials and methods: This prospective, cross-sectional, observational study began following ethical approval. The study covered 182 patients. Categorical data were compared using the chi-square test, whilst normally distributed con- tinuous data were examined using the unpaired t-test. The odd ratios for quality-of-life impairment were determined using univariate binary logistic regression analysis (QOL). Results: Across the groups of people with controlled and uncontrolled diabetes, there were significant differences in family structure and marital status (p<0.05). When compared to the group with controlled diabetes (133.55 ± 49.01 and 6.16 ± 0.33) the FPG and HbA1c were considerably higher in the uncontrolled diabetes group (154.73 ± 55.18 and 7.81 ± 1.11). In the two groups, there was a substantially different duration of diabetes mellitus (p = 0.004). Conclusions: There were significant variations in the mean age, HbA1c (%), FPG, and duration of diabetes mellitus and widowed patients between the uncontrolled and controlled diabetes groups, resulting in a reduced quality of life in uncontrolled diabetes patients.Item Pharmacoeconomic Evaluation of Antidiabetic Medication in Geriatric Type 2 Diabetes- A Brief Study(?Eldaghayes Publisher, 2024-12) Jakhar, A; Hussain, S; Hussain, MS; Saifi, L; Usman, K; Sawlani, KK; Khattri, S.Introduction: Diabetes mellitus (DM) is a long-term condition that poses an enormous health and economic burden on society. Unfortunately, there is a dearth of such evidence in India. Hence, we sought to estimate the direct cost of antidiabetic medication in the geriatric population. Aim and Objectives: The aim of this study is to evaluate the pharmacoeconomic of antidiabetic medication in geriat- ric type 2 diabetes mellitus patients attending outpatient department in a tertiary care teaching hospital. Materials and Methods: The demographic characteristics, clinical characteristics, and treatment profiles of patients were compiled. All diabetic patients who visited an outpatient department had their prescriptions recorded. A pharma- coeconomic analysis of prescribed anti-diabetic medications was conducted. Results: The study enrolled 600 DM patients, of which 67.83% were males, 32.17 % were females, and the pre- dominant age group was 60–64 years. In 94.54% of patients, the most frequently prescribed antidiabetic drug was metformin 500 mg. In 39.31% of patients, the most frequently prescribed antidiabetic combination was glimepiride 2 mg + metformin 500 mg. Insulin was prescribed in 14.83% of the cases. The percentage cost difference for diabetes medications ranges from 43.010 to 644.444. The monthly cost of monotherapy for most patients with controlled diabe- tes (31.46%) and uncontrolled diabetes (42.12%) was between 500 and 1000 INR. In addition, the cost of combination therapy ranges between INR 118.91 and INR 300.27. Conclusion: The costs associated with diabetes are immense and impose a substantial burden on society. Consequent- ly, policymakers should prioritize preventing the disease and its associated problems.Item Unusual clinical presentations of scrub typhus, a neglected tropical disease: A case series from north India(Wolters Kluwer – Medknow, 2022-10) Verma, Shiva; Shukla, Suruchi; Prakash, Shantanu; Jain, Amita; Himanshu, D; Sawlani, KKBackground & objectives: Scrub typhus is a neglected tropical disease common in Asia and Africa. It usually presents with non-specific symptoms like fever, rashes, and lymphadenopathy. It has a varying range of clinical picture that often leads to misdiagnosis and initiation of non-specific treatment. This disease is thus associated with high morbidity and mortality. We aim to highlight the uncommon presentations of this common disease to create awareness regarding the unusual presentations of scrub typhus. Methods: This prospective study was performed over a period of two months enrolling eleven adult patients with serological evidence of anti-scrub typhus IgM antibodies. Results: All enrolled 11 cases [5 males (45.5%) and 6 females (54.5%)] were positive for anti-ST IgM antibodies and negative for other tested microbial agents. 7/11 (63.6%) patients were admitted with a clinical diagnosis of acute encephalitis syndrome (AES as per standard WHO definition), 3/11 (27.3%) patients presented with jaundice and 1/11 (9.1%) patients presented with rashes. Two out of 7 (28.6%) AES cases had developed peripheral gangrene of extremities. Interpretation & conclusion: Scrub typhus is a common tropical disease that can have various unusual clinical presentations like meningoencephalitis, vasculitis, acute kidney injury, jaundice, MODS. It closely mimics other infective etiologies making its diagnosis difficult. A high index of suspicion and clinical awareness is required in clinical practice to identify the different presentations of this disease so that early treatment can be initiated to reduce morbidity and mortality associated with this disease.