Browsing by Author "Sarma, D."

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    BERA in the detection of hearing loss in high risk children: an observational study in two tertiary care teaching hospitals in upper Assam region
    (Medip Academy, 2023-12) Mili, M. K.; Sarma, D.; Sarmah, M.; Goswami, S.; Pegu, K.; Talukdar, L.; Talukdar, S.; Siddique, M.
    Background: Significant hearing loss affects children globally (1-3/1,000 infants at birth). Early diagnosis (<6 months age) and subsequent early intervention facilitates normal development of language, regardless of the severity of hearing loss. Methods: A hospital-based, descriptive, retrospective study was done in two tertiary-care centres of Upper Assam region, upon total (55 + 46 =) 101 high risk children (<15 years) during a study period of 1 year. Patients were subjected to a questionnaire, and hearing tests (BERA/OAE) were performed. Results: Majority of the cases were <5 years of age, with male preponderance (66.30% cases). NICU graduates with history of ototoxic medications/mechanical ventilation, neonatal hyperbilirubinemia and caregiver concern were the common presenting risk factors identified. Conclusions: 49.50% cases (n=50) suffered from hearing loss [most common was severe degree of hearing loss, n= 24]. 75% cases in AMCH and 63.6% in LMCH with caregiver concern, 55.55% cases in AMCH and 50% in LMCH with past neonatal hyperbilirubinemia; 50% cases with positive family history; and 46.66% NICU graduates tested positive for hearing loss. Ideally, all high risk children <15 years should be screened for hearing loss with earliest intervention and rehabilitation, to enable them to lead a normal life and reduce the burden of handicap in the community.
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    Evaluation of Nymphaea nouchali leaf meal based diets on growth, digestive enzymes and haematological parameters of Labeo catla fingerlings (Hamilton, 1822)
    (Triveni Enterprises, 2024-07) Daflari, B.; Saharia, P.K.; Talukdar, A.; Baishya, S.; Sarma, D.; Bhagawati, K.; Bordoloi, B.; Saikia, P.; Thakuria, J.
    Aim: This study was conducted to evaluate the nutraceutical traits of Nymphaea nouchali herbal plant ingredients on the growth performance, digestive enzymes and health status of Labeo catla fingerlings owing to the abundance of phytoconstituents. Methodology: Four isonitrogenous and isocaloric diet with different inclusion levels of Nymphaea nouchali leaf meal (NNLM) i.e., 0%, 20%, 30% and 40% were formulated and designated as T-0, T-I, T-II and T-III treatment groups. A total of 144 fingerlings of L. catla were randomly distributed into the experimental cisterns in triplicates following completely randomized design. Results: At the end of the experiment, the percent weight gain and specific growth rate (SGR) were significantly higher (P<0.05) with significantly lower (P<0.05) feed conversion ratio (FCR) in T-II group as compared to the other experimental groups. Significantly lower (P<0.05) percent weight gain and SGR with significantly higher (P<0.05) FCR were recorded in T-0 and T-III. The protease and amylase activities were found to be significantly higher (P<0.05) in the T-II with lower (P<0.05) values recorded in T-0 and T-III groups. The red blood cell count and haemoglobin level were found to be significantly higher (P<0.05) in the T-I and T-II groups as compared to T-0 and T-III, respectively. Interpretation: The present study demonstrated that dietary inclusion of Nymphaea nouchali leaf meal with 30% improved growth, nutrient utilization and better health benefits of L. catla fingerlings in the present culture condition.
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    Morphometric trait normalization, cluster analysis and molecular phylogenetic analysis in delimiting sympatric Neolissochilus hexastichus and N. hexagonolepis in Umngi River, Meghalaya (India)
    (Triveni Enterprises, 2024-12) Laskar, M.A.; Sarma, D.; Nath, R.; Kharbani, R.; Shahi, N.; Haldar, R.S.; Ganie, P.A.
    Aim: To assess the ability of an integrative approach comprising multivariate morphometric data analysis and mitochondrial cytochrome oxidase subunit I (CO I) sequence divergence analysis in delimiting sympatric Neolissochilus hexastichus (McClleland, 1839) and N. hexagonolepis (McClleland, 1839) mahseer populations in River Umngi, Meghalaya. Methodology: Authoritative descriptions of mahseers were referred during the sampling of 40 individuals from River Umngi, Meghalaya. Multivariate morphometric data were normalized with respect to standard length. The normalization procedure maintained the particular shape factor for each sample. Normalised data were subjected to hierarchical clustering on principal components Analysis (HCPC) for grouping samples according to morphometric features. Genetic affinities based on CO I sequence divergence were assessed by Bayesian Inference (BI) and Automatic Barcode Gap Discovery (ABGD) protocols. Results: The normalization protocols removed the variations in traits due to body size effects and facilitated the identification of allometric traits. HCPC analysis revealed morphometric features that had a significant impact on clustering. Nine N. hexagonolepis and 13 N. hexastichus individuals were identified by integrative morphological and molecular phylogenetic approach. The remaining 18 individuals had incongruence in their memberships in the morphometric and phylogenetic clusters. Interpretation: The integrative approach, apart from delineating N. hexagonolepis and N. hexastichus congeners, highlighted the need to include nuclear genetic markers in future studies for confirming the presence of natural hybrids in sympatric populations of Neolissochilus mahseers.
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    Phenotypic stability and homeostasis in Assam rice landraces at varying nitrogen regimes
    (Triveni Enterprises, 2019-11) Das, S.; Sarma, D.; Das, S.S.
    Aim: The present study was designed to identify stable rice (Oryza sativa L.) genotypes for nitrogen use efficiency (NUE), yield and its component traits and also to identify component traits associated with yield stability. Methodology: Twenty-one landraces along with five high yielding varieties (HYVs) of rice were evaluated at three nitrogen levels (0, 40 and 60 kg N ha-1) for two years (2014 and 2015). Eberhart and Russel’s (1966) stability analysis were employed to assess the genotype × environment (GE) interaction and the stability of the genotypes across six environments. To study homeostasis, simple correlation analysis among ten different traits was done based on stability parameters. Results: The present study revealed that environments created by graded nitrogen levels were fruitful for inducing environmental variations. The highly significant linear environmental variances were found for all ten traits. Linear GE interaction was significant for all the traits, except harvest index, grain nitrogen and nitrogen harvest index. The stability analysis identified four genotypes viz., Kolabor, Aki Bora, Rongdoi and Luha Sali with average stability whereas Betguti Sali was found to be stable below average. Correlation analysis based on stability parameters revealed the existence of homeostasis. Interpretation: Present study revealed that genotypes namely Kolabor, Aki Bora, Rongdoi and Luha Sali are suitable to grow under both nitrogen limiting and nitrogen non-limiting environments whereas Betguti Sali was suitable for nitrogen non-limiting environments. Correlation analysis, based on stability parameters, revealed that yield stability was due to the plasticity of some other component traits under study.
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    Role of serum CA 19-9 as a tumor marker in TCC bladder
    (Medip Academy, 2019-04) P., Rajeev T.; Das, Nabajeet; Baruah, S. J.; Barua, S. K.; Bagchi, P. K.; Sarma, D.; Phukan, M.
    Background: There is a dearth of reliable blood and urine markers for transitional cell carcinoma of urinary bladder. CA 19-9 is a well-known marker for gastrointestinal malignancies and is being investigated for other malignancies including carcinoma bladder. In this prospective study, we evaluated the role of serum CA 19-9 as a tumor marker and correlated its level with tumor grade and stage.Methods: One hundred and fifteen patients with transitional cell carcinoma of urinary bladder and 69 healthy volunteers, as controls were included in the study. Preoperative blood sample was analysed for level of CA 19-9 using ELISA kit (normal - 0 U/ml to 37U/ml) and were correlated with grade and TNM stage of tumor.Results: The range of the control group is 2-38U/ml (mean: 17.67±9.68U/ml); TCC group is 1-94U/ml (mean: 37.12±31.52U/ml) (p=0.304). When CA 19-9 level >37IU/ml was taken as cut-off for a positive test, sensitivity of detecting T3 disease, T4 disease, MIBC, presence of node and high grade tumour were 80%, 75%, 70.3%, 78% and 57.8% respectively. However, there was a statistically significant increase in levels of CA19-9 in relation to higher grade (<0.001), presence of muscle invasion (<0.001), T stage (<0.001) and N stage (<0.001).Conclusions: Serum CA19-9 is almost invariably raised in patients with high grade and invasive disease. Thus, it has a place as a prognostic marker rather than as a diagnostic tool due to its low sensitivity for TCC bladder.
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    Urolithiasis in vegetarian population attending a tertiary care centre: a retrospective study
    (Medip Academy, 2023-07) Rahman, MA; Barua, SK; Bagchi, PK; Phukan, M; Sarma, D.
    Background: Urolithiasis is the one of the most common urological disease with kidney stone, being the most painful and prevalent urological disorders of the urinary system. Its prevalence has drastically increased during the present century with 3–20% of the overall population of the world having the tendency to form one urinary stone during the life time of 70 years. Diet is an integral part of renal accumulation and thus filtration, which in turn affects the absorption and bodily homeostasis of renal stone occurrence. The epidemiology differs in accordance with different geographical regions and social constructs. Within this context, food habits have been proposed as one of the major risk factors in renal stone formation, as a form of epidemiology for urine composition. With this background, this study is designed to study the incidence of urolithiasis in the vegetarian population of northeast India. Methods: The study was designed as an observational study by including all the patients diagnosed with having urolithiasis on imaging who was managed according to different treatment modalities. Patients included in the study were enquired about their diet habits and were recorded. Results: Out of the 151 cases of urolithiasis being studied, prevalence in male were 2.5 times more than female. Age group 31-40 years comprised of most number of patients with calculi (28.5%). Kamrup (metro and rural) had the most number of urolithiasis cases (33.8%). 5 cases of urolithiasis were found to be pure vegetarian (3.3%). 38.4% of the patient had a history of smoking. Conclusions: Most of the patients had unilateral calculi. Majority of the urolithiasis patient hailed from Kamrup (rural and metro) district, followed by Darrang and Nalbari district. Vegetarian group of patient with urolithiasis had significant history of alcohol intake, smoking and tobacco chewing.