Browsing by Author "Sachdev, Namrita"

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    Clinical utility of TIRADS and ultrasound elastography in characterization of thyroid nodules
    (Medip Academy, 2019-02) Sachdev, Namrita; Sana; Gupta, Shivani; Prasad, Akhila
    Background: Thyroid nodules are a common entity in an iodine deficient population, however malignant nodules are relatively uncommon with excellent prognosis. Ultrasound elastography is a useful tool for characterization of nodules and allows selection of tumors for FNAC. This study aimed to evaluate the diagnostic value of strain elastography and acoustic radiation force impulse (ARFI) imaging in differentiating malignant from benign thyroid nodules.Methods: This study included 100 thyroid nodules evaluated using ultrasound TIRADS classification. Strain elastography evaluated the nodules using the elasticity score and strain ratio followed by VTI and shear wave velocity generated from ARFI data to characterize the nodules. Final diagnoses were obtained from cytological and/or histological evaluation. The diagnostic performance of the two elastography methods was analyzed and compared by multiple receiver operating characteristic curve analysis.Results: Of the 100 thyroid nodules observed in 100 patients (82 females and 18 males), 22% were malignant nodules and 78% were benign. The cut off values for elasticity scores, mean SR, VTI grade and mean SWV for predicting malignant thyroid nodules were greater than or equal to score 2, 2.4, grade 3, 2.5m/s respectively. The area under the receiver operating characteristic curve for elasticity score, mean SR, VTI grade and mean SWV was 0.79, 0.78, 0.89 and 0.84, respectively (P>0.05) and the accuracy was 74, 81.6, 88 and 87.5%, respectively (P>0.05). The accuracy of the combined use of conventional sonography, strain elastography and ARFI imaging was 85.6% respectively, which was higher than that of conventional sonography (P>0.05).Conclusions: Strain elastography and ARFI imaging have high sensitivity and specificity for differentiating malignant from benign thyroid nodules and therefore have good clinical utility in evaluating these lesions.
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    Encephalitic presentation of Neonatal Chikungunya: A Case Series
    (Indian Academy of Pediatrics, 2018-08) Maria, Arti; Vallamkonda, Nagaratana; Shukla, Amlin; Bhatt, Aditya; Sachdev, Namrita
    Objective: To describe clinical features and early neurological outcomes in neonatalChikungunya. Methods: Clinical, pathological and radiological details of neonates with acuteencephalitic features and typical rash, later diagnosed as Chikungunya, are presented.Neurodevelopmental evaluation and imaging was done at discharge/three months. Results:Abnormal neurological examination with fever was typical presentation in all 13 babies with/without seizures/peri-oral rashes; 12 had persistent neurological abnormalities at discharge.A follow-up at three months revealed continued neurodevelopmental deficits. Neuroimagingabnormalities were seen in eight out of ten cases. Conclusions: Perinatal Chikungunyashould be considered in neonates presenting within first week with fever, encephalopathy andperioral rashes with/without seizures with history of maternal Chikungunya within last weekbefore delivery.
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    Magnetic resonance imaging of temporomandibular joint in juvenile idiopathic arthritis
    (Medip Academy, 2020-05) Sachdev, Namrita; Singh, Yashvant; Rampal, Parikha; Sana
    Background: Juvenile Idiopathic Arthritis (JIA) is the most common autoimmune inflammatory synovial arthritis causing wide range of disability in children. The involvement of temporo-mandibular joint (TMJ) in JIA varies ranging from 17% to 87%. Unlike other synovial joints, the TM joint is particularly vulnerable to inflammatory damage as the mandibular growth plate is superficial. JIA is a clinical diagnosis and is characterized by synovial hyperplasia and inflammation leading to joint effusion. TMJ involvement is clinically difficult to assess and often goes untreated. Children with TMJ arthritis have mastication dysfunction and pain. Delayed detection and treatment leads to abnormalities like micrognathia, jaw deformity, facial dysmorphism and chewing problems. MRI is the most sensitive modality to diagnose synovitis and involvement of TMJ in children of JIA.Methods: A cross-sectional observational study was undertaken in 30 children diagnosed as JIA as per ILAE criteria. They were evaluated clinically followed by contrast enhanced MRI for evidence of TMJ arthritis.Results: Of the 60 joints evaluated, clinical involvement was found in 18 joints (10 patients). 12(66.7%) out of them had MRI changes. 3(7.1%) joints out of 42 asymptomatic joints had MRI changes. 13 joints had synovial hypertrophy, 8 joints showed bone erosions. Bone marrow edema was seen in 2 joints, with no evidence of cartilage involvement in any joint. The sensitivity, specificity, PPV and NPV of clinical examination to diagnose TMJ arthritis as compared to MRI was 80.0%, 86.7%, 66.7% and 92.7% respectively.Conclusions: With paucity of clinical signs and symptoms, early involvement of TMJ arthritis in children of JIA can be detected by MRI to prevent long term disability in patients.
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    Mature cystic teratoma mimicking ectopic pregnancy: a case report
    (Medip Academy, 2023-11) Verma, Deepak; Kumar, Sumit; Sachdev, Namrita
    We present a case of mature cystic teratoma resembling ectopic pregnancy in a patient with positive serum beta-hCG and an adnexal mass. A 30-year-old woman who was experiencing pelvic pain and vaginal bleeding was sent to the emergency room. An ultrasound revealed a complex right adnexal mass measuring 63� mm and the absence of an intrauterine gestational sac. Based on these findings, ectopic pregnancy was suspected; nevertheless, a subsequent magnetic resonance imaging (MRI) was planned, which suggested mature cystic teratoma. On a laparoscopy, later findings were verified. Cyst removal was the patient's treatment. Despite the possibility of an ectopic pregnancy being indicated by the existence of an adnexal mass without an intrauterine gestational sac and a positive beta-hCG level, a mature cystic teratoma should be considered as a differential diagnosis.
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    Multi detector computed tomography imaging in penetrating injuries
    (Medip Academy, 2020-06) Sachdev, Namrita; Singh, Yashvant; Sana; Mehta, Dipshi
    Background: Penetrating injuries forms an important component of surgical emergencies. Penetrating trauma typically involves the violation of the body by a gunshot wound (GSW) or stab wound. Emergency laparotomy is the accepted management in patients with a penetrating injury who are not hemodynamically stable. However, selective non-operative management has been shown to decrease the rate of unnecessary surgery. Plain radiographs and FAST are useful for initial assessment of these patients. Multi detector CT is an indispensable tool in the evaluation of patients who are stable and are candidates for conservative treatment.Methods: A cross sectional observational study was carried out on 40 patients admitted with penetrating injury to the trauma centre of PGIMER and Dr RML hospital. Of the 40 patients, 14 were taken for emergency laparotomy. In 26 cases, MDCT was done to evaluate for solid organ, hollow organ and vascular injuries.Results: The mean age of patients was 38 years, with male to female ratio of 5:1. Stab injury was the commonest type of injury, followed by gunshot wounds. Liver was the commonest solid organ involved, followed by kidneys and spleen. Other organs involved were diaphragm, small bowel and colon.Conclusions: Penetrating injuries can be life-threatening, making prompt diagnosis essential. Recognizing key abnormalities on MDCT ensures patients are triaged appropriately. Multi-detector CT is thus widely used to evaluate penetrating injuries in stable patients.
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    Role of hippocampal volumetry in drug resistant epilepsy
    (Medip Academy, 2019-08) Sachdev, Namrita; Gupta, Shivani; Singh, Yashvant
    Background: Hippocampus is a brain structure located deep in the temporal lobe. The structure is crucial for learning and memory and is a natural inhibitor of seizure activity in brain. In drug resistant epilepsy (DRE), there is shrinkage of the hippocampus leading to poor seizure control.Methods: Patients meeting the diagnostic criteria for drug resistant epilepsy between the age group of 10-60 years were enrolled in the study. Epileptic non drug resistant controls and normal healthy individuals were taken from same cohort. Selected patients underwent MRI Brain and their hippocampal volumes were estimated manually. Coronal oblique sections, perpendicular to the long axis of hippocampus were taken and hippocampal volume (HV) were calculated using region of interest approach with manual delineation . Results: There was increment in detecting hippocampal atrophy from 30% to 46.6% in DRE patients when manual hippocampal atrophy was used in addition to visual assessment. The mean right and left hippocampal volumes in drug resistant epilepsy cases were found to be 2.17+0.57 cc and 1.52+0.54 cc respectively. Left HV was found to be statistically significantly smaller than right side (p value < 0.05). DRE patients had smaller mean bilateral HV than healthy controls, the difference being 33%. The left HV loss was almost double the right HV loss among DRE cases. The hippocampal volumes were reduced in DRE patients compared to epileptic non-resistant patients; however the difference was found to be less than that of normal healthy controls.Conclusion: Manual hippocampal volumetry detected more patients with hippocampal atrophy in our study compared to visual assessment. Manual hippocampal volumetry should be routinely done in patients with Drug resistant epilepsy.