Browsing by Author "S, Malini"

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    Comparison of efficacy of intrathecal preformed hyperbaric levobupivacaine and bupivacaine with buprenorphine in infraumbilical surgeries - A prospective, randomised, clinical study.
    (S. Nijalingappa Medical College & HSK Hospital & Research Centre, 2024-01) S, Malini; K, Poolandevi; Murdeshwar, Greeshma N; V, Yashoda
    Introduction: Baricity determines the spread of local anaesthetic agent in the cerebrospinal fluid. Hyperbaric bupivacaine was widely used for sub-arachnoid blockade. Levobupivacaine is S-enantiomer of racemic bupivacaine. There are studies where isobaric levobupivacaine is converted to hyperbaric form by adding dextrose solution. Recently there is availability of preformed hyperbaric levobupivacaine with 8% glucose. Aims and objectives: We have done this study with primary objective to compare the sensory and motor blockade characteristics of preformed hyperbaric levobupivacaine with hyperbaric bupivacaine, after subarachnoid block, among the patients posted for infraumblical surgeries. Secondary objective is to compare the haemodynamic stability and post-operative analgesia duration. Methods and methodology: This is a prospective, randomized, controlled, double blinded clinical trial. 200 patients posted for infraumblical surgeries were randomly allocated in two groups. Group-B and Group-L received preformed HB and HB respectively with 0.2 ml buprenorphine. Sensory and motor blockade characteristics, analgesia duration and patients with hypotension were noted down. Result: There was no statistical significant difference in the sensory and motor blockade characteristics between HB and HL like sensory onset time (HB-111.9± 49.75 s; HL-111.9± 49.75 s; P=0.789); motor onset time (HB- 128.87± 78.13 s; HL 123.76± 87.83 s; P=0.664); maximum sensory level attained (HB-7.04± 1.59 and HL-7.16± 1.58; P=0.594); time taken for maximum sensory block (HB-365.6± 108.6 s; HL- 361.95±97.86 s; P=0.803) and maximum motor blockade (HB-451±133.7 s; HL-450.95± 121.86 s; P=0.997). Post-operative analgesia duration (HB-249.55±70.7 min; HL-270.7±92.9 min, P=0.072) and patients with hypotension were HB-19% and HL-17% was also not statistically significant (P=0.713). Conclusion: Preformed HL with buprenorphine is also a safe and better choice for spinal anaesthesia in infraumblical surgeries like HB because of its similar sensory blockade, motor blockade and haemodynamic effects as with preformed HB with buprenorphine.
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    Promising Ayurvedic Herbs In The Management Of Kitibha (psoriasis)- A Review
    (Mahadev Publications, 2018-01) Krishna, C. Murali; Kumar, D. Panchajanya; Sivaram, G.; S, Malini; Venkateshwarlu, B.; Dhoke, Sujata P; Babu, G.
    Psoriasis is one of the commonest skin disorders seen in routine clinical scenario, in entire world around 80 million people suffering from psoriasis. Psoriasis is differentiated by patches of abnormal skin. These skin patches are typically red, itchy, and scaly. Psoriasis varies in severity from small, localized patches to complete body coverage. It typically presents as red patches with white scales on top. Areas of the body most commonly affected are the back of the forearms, chin, navel area, and scalp. Diagnosis is typically based on the signs and symptoms. Men and women are affected with equal frequency. The disease may begin at any age, but typically starts in adulthood. Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease and depression. Psoriatic arthritis affects up to 30 percent of individuals with Psoriasis. It is noted that around 2% of population are touching with Psoriasis. In present study review on Herbs frequently used in treating psoriasis were compiled. The Herbs Nimba, Stri Kutaja, Guduchi, Daruharidra, Bhallataka Haritaki, Aragvadha, Amalaki, Karveera, Saptaparna, Khadira, Vasa, Guggulu, Chitraka & Katuki are reviewed to be having Vata or Kapha balancing properties. The pharmacological studies showing that Nimbidin of Neem having anti psoriatic property, The Methanolic and ethanolic extracts of Stri Kutaja and Guduchi are having anti oxidant and anti psychotic properties which are helpful in reducing the symptoms of psoriasis.