Browsing by Author "Rudrappa, Sudha"

Now showing 1 - 6 of 6
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    Liver function tests to predict the severity of dengue fever in serologically positive children below 18 years of age
    (Medip Academy, 2019-03) H. N., Yashwanth Raju; Kumar, Rajendra; Rudrappa, Sudha
    Background: Dengue fever presents with a diverse clinical spectrum. Although liver is not a major target organ, hepatic dysfunction is a well-recognized feature. In this study authors attempted to study the pattern of hepatic involvement in children with dengue and its association with disease severity.Methods: This was a cross sectional study conducted at Cheluvamba hospital during the period of 1 year. Children <18 years of age with dengue Ns1 Ag and IgM positive were included in this study. After obtaining informed consent, a pre-structured proforma was used to record the relevant information from each subject. After detailed clinical examination and haematological investigation children were categorized into three groups as dengue fever with no warning signs (DNWS), dengue fever with warning signs (DWWS) and severe dengue fever (SDF) according to WHO classification. Statistical analysis was done to know the strength of association between different clinical and biochemical variables and outcome of the disease.Results: The mean age of the study population was 8.65 years with male preponderance. The mean total bilirubin, serum albumin, SGOT, SGPT, ALP, PT and INR were 0.76 mg/dl, 3.8g/dl, 233.18U/L, 118.15U/L, 200.65 U/L, 12.9s and 1.09 respectively. The mean SGOT was significantly higher than SGPT. The degree of deranged LFTs was significantly more in SDF group than DNWS and DWWS groups. Serum albumin was significantly decreased in children with SDF group correlating with disease severity, prognosis and outcome.Conclusions: Hepatic dysfunction was present in all forms of dengue infection, with SGOT rising significantly more than SGPT. All biochemical liver parameters were significantly deranged in patients with severe dengue fever indicating prolonged illness and poor prognosis.
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    Mid-stream clean catch urine collection in newborns: a non-invasive and safe technique
    (Medip Academy, 2019-03) Kumar, Rajendra; Nithin; Rudrappa, Sudha
    Background: The aim of this study is to determine the success rate and safety of a non-invasive technique to obtain clean-catch midstream urine samples in newborns.Methods: Prospective bedside clinical study. After obtaining written informed consent,120 consecutive newborns admitted in NICU with no dehydration, poor feeding, need for immediate urine sample by invasive method' for whom urine collection was advised for various reasons who met the inclusion criteria were included in the study with consent being taken from the parents. After adequate milk intake supra pubic and lumbar para vertebral areas were stimulated in repeated cycles of 30 s until micturition began.Results: Success rate in obtaining a midstream urine sample within 5 min. The success rate was 90%. The mean time taken to collect urine was 64.24s, for males it was 62.55s and for females 65.93s.Conclusions: The technique has been demonstrated to be safe, quick and effective. The discomfort and time consumption usually associated with bag collection methods as well as invasive techniques can be avoided.
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    Oculo-facio-cardio-dental syndrome in a girl and her mother.
    (2010-09) Rudrappa, Sudha; Kumar, Rajendra; Kumar, G S
    Congenital heart defects are known to be associated with facial dysmorphism and other congenital anomalies. Oculo-facio-cardio-dental (OFCD) syndrome is one such rare multiple congenital anomaly syndrome inherited as an X-linked dominant condition characterized by congenital cataracts, multiple minor facial dysmorphic features, congenital heart defects and dental anomalies. It is unrecognized by many medical and dental professionals. Only 21 cases have been reported so far. This syndrome is often misrecognized as rubella embryopathy because of association of congenital cataract with cardiac anomalies. It is usually the orthodontists who diagnose the syndrome based on typical findings on dental panoramic radiographs. But we suspected our patient to be having OFCD syndrome based on typical facial dysmorphism, ocular and cardiac defects, and finally it was confirmed after noticing typical dental radiographic findings.
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    Podophyllin poisoning.
    (2002-06-27) Rudrappa, Sudha; Vijaydeva, L
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    Study of eosinophil count in nasal smear and peripheral blood smear in children with allergic rhinitis
    (Medip Academy, 2019-05) Rudrappa, Sudha; Kumar, Rajendra; Kumar, Vinay
    Background: Allergic respiratory disorders are the common cases seen in Pediatrics OPD. With an appropriate history and detailed examination, the diagnosis usually may not be problematic and routine investigations may not contribute much for the final diagnosis but may help in ruling other possibilities. The objectives of this study were done to know the eosinophil counts in nasal and blood smear and to assess the feasibility of nasal cytogram which is simple, economical and reliable investigation in patients of allergic respiratory disorders.Methods: A prospective clinical correlation study conducted in outpatient visiting Mysore Medical College and Research Institute, Cheluvamba hospital Department of Pediatrics and ENT Department KR hospital. 60 children of age group between 2 to 18 years were selected to estimate the eosinophil count in nasal and peripheral smear in allergic rhinitis. All allergic rhinitis cases based on clinical signs and symptoms were selected and investigated for nasal and blood eosinophilia. The nasal and blood eosinophilia were compared with each other and the clinical findings of allergic rhinitis were studied.Results: In this study peak age incidence is between 6-10 years and there is equal gender distribution. Seasonal variation and pollen allergens were the most common risk factors for allergic rhinitis. Running nose and the nasal obstruction were the most common symptoms in children with allergic rhinitis followed by sneezing and itching. One tenth of the children with allergic rhinitis had bronchial asthma. Nasal eosinophilia contributes to the diagnosis of allergic rhinitis as compared blood eosinophilia. Mild intermittent variety of allergic rhinitis was the most common form of allergic rhinitis.Conclusions: Among various risk factors for allergic rhinitis, seasonal variation and pollen allergens have significant association with the severity of allergic rhinitis. Among various symptomology, only itching had a significant relation to the severity of allergic rhinitis.
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    Thyroid function and thyroid autoimmunity in type 1 diabetes mellitus: impact on glycemic control
    (Medip Academy, 2023-09) Narasimhegowda, Meghana; Rudrappa, Sudha; Gopal, Girish
    Background: The frequency of AITD (autoimmune thyroid disease) and prevalence of thyroid autoantibodies in T1DM (Type 1 diabetes mellitus) patients is much higher than in general paediatric population, varying widely between 3-50% and is often related to age, gender and ethnicity. Although this association has been well established in various populations, very few studies have been done in this regard in South India. The objectives of the study were to study the proportion of abnormal thyroid function and thyroid autoimmunity among T1DM subjects in comparison with general pediatric population and to compare the disease severity among T1DM subjects with and without abnormal thyroid function.Methods: The 45 subjects diagnosed with T1DM (Group 1) and 45 age and gender matched subjects without T1DM (Group 2) were enrolled after applying the inclusion and exclusion criteria. Serum free T3, free T4 and TSH levels were tested for all the subjects in both the groups. In addition, HbA1c levels and Anti TPO antibody titers were tested for subjects with T1DM.Results: Abnormal thyroid function was found in 15.5% of T1DM subjects, in contrast to 2.2% of subjects in the comparison group (p=0.026). The anti-TPO antibody titers were positive in 31.1% of T1DM subjects and among them 42.8% subjects had abnormal thyroid function. T1DM subjects with abnormal thyroid function had significantly higher number of hospitalizations (p<0.05) and total number of ICU admissions (p<0.05)Conclusions: Abnormal thyroid function (predominantly subclinical hypothyroidism) and thyroid autoimmunity was not only more prevalent among T1DM subjects, but was also associated with poor glycemic control. Thus, highlighting the need for screening and a lower threshold for treatment.