Browsing by Author "Rao, D. Srinivas"
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Item Anti-Biofilm Activity of Monolaurin on Staphylococcus aureus: An in-silico Study(Society for Scientific Research, 2022-12) Rao, D. Srinivas; Shameerasm, Rabiathul; Prathusha, KL; Verma, Mahendra Kumar; A, Rekha; Rao, M. V. RaghavendraBackground: Background: Staphylococcus aureus is a gram-negative bacterium that can build strong biofilms on biotic and abiotic surfaces, quickly acquire drug resistance mechanisms, and cause major issues with the treatment of hospital infections. The creation of new therapeutic options has become important due to the limited supply of new antibacterial medications. One of the main sources of bioactive molecules is medicinal plants, and monolaurin is a naturally occurring substance with a variety of biological functions. In light of this, the goal of this study was to assess monolaurin's antibiofilm activity against S. aureus. Methods: Using the AutoDock programme, a docking study of monolaurin against Clf A (clumping factor A) was carried out, and Pymol software was used to evaluate the generated hydrogen bonds in the docked complex. This study demonstrates the positive potential of monolaurin as an antibacterial product and lends support to upcoming pharmacological research on this molecule with an eye toward its therapeutic use. Results: Research was done to support the theoretical absorption of monolaurin in this work and in silico. It was feasible to forecast if the monolaurin molecule may be produced as a medication based on the values of the physical-chemical parameters evaluated using the online tool Swiss ADME. Conclusion: The compound monolaurin demonstrated good receptor ClfA binding affinity with an estimated binding energy of kcal/mol. Natural anti-staphylococcal chemical monolaurin was used as a possible medicine for treating staphylococcal infections in humans by carrying out drug design studies for S. aureus.Item Preference for male child among married adults in rural and urban field practice areas of Narayana Medical College, Nellore, Andhra Pradesh, India(Medip Academy, 2020-02) Vardhan, Y. Vishnu; Rao, D. SrinivasBackground: Reduction of national fertility levels was directly proportional to the preference of male child in many families in India. We conducted this study on 214 married adults, in both sexes to find out whether this strong preference still exists in this decade or not, and if it does what could be the reasons.Methods: A community based cross-sectional study done by face to face interviews using a semi-structured questionnaire containing both qualitative and quantitative variables, among 214 married adults.Results: Upon analysing the results, we identified that higher son preference (61.23%) is seen in many rural families, and is strongly associated with low socio-economic status, literacy rate and caste. The reasons by which these families prefer male child were also broadly categorized and identified. Economic utility (78%) and old age security (61%) was found to be the major reasons most families has quoted in preferring a son.Conclusions: By improving the literacy rate and job opportunities in the community, fertility rate can be reduced, especially in rural areas where the other options are limited.