Browsing by Author "Raja, T"
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Item A case of primitive neuroectodermal tumor of the kidney and review of the literature.(2012-10) Shringarpure, Sanish S; Venkatraman, Murali; Raja, T; Mani, RamaItem Ignore molecular oncology at your peril.(2014-04) Parikh, P M; Prabhash, K; Bhattacharyya, G S; Sirohi, B; Rajappa, S; Verma, A; Raja, TItem Management of primary and metastatic triple negative breast cancer: Perceptions of oncologists from India.(2011-04) Parikh, P M; Gupta, S; Parikh, B; Smruti, B K; Issrani, J; Topiwala, S; Goswami, C; Bhattacharya, G S; Sen, T; Sekhon, J S; Malhotra, H; Nag, S; Chacko, R T; Govind, K Babu; Raja, T; Vaid, A K; Doval, D C; Gupta, S; Das, P KBackground: In order to document the understanding of current evidence for the management of triple negative breast cancer and application of this knowledge in daily practice, we conducted an interactive survey of practicing Indian oncologists. Materials and Methods: A core group of academic oncologists devised two hypothetical triple negative cases (metastatic and early breast cancer, respectively) and multiple choice options under different clinical circumstances. The respondents were practicing oncologists in different Indian cities who participated in either an online survey or a meeting. The participants electronically chose their preferred option based on their everyday practice. Results: A total of 152 oncologists participated. Just over half (53.8%) preferred taxane based chemotherapy as first-line chemotherapy in the metastatic setting. In the adjuvant setting, a taxane regimen was chosen by 61%. Over half of respondents (52.6%) underestimated the baseline survival of a patient with node positive triple-negative tumor and 18.9% overestimated this survival compared to the estimate of the Adjuvant! program. Discussion: This data offers insight into the perceptions and practice of a diverse cross-section of practicing oncologists in India with respect to their therapeutic choices in metastatic and adjuvant settings in triple negative breast cancer.Item Optimizing second-line therapy for chronic myeloid leukemia.(2012-01) Raja, TTreatment of chronic myeloid leukemia has evolved from symptom control to long-term disease-free survival with cure potentially round the corner. This required faster, deeper, and longer response. Optimizing treatment decisions therefore requires clear understanding of and strict implementation of guidelines for shift from imatinib. In patients who are resistant to or intolerant of imatinib, second-line TKIs have to be selected carefully. Currently available data show comparable efficacy between nilotinib and dasatinib. With a better safety profile (especially with respect to grade 3 or 4 hematologic toxicity and clinically relevant non-hematologic toxicities), nilotinib becomes the preferred choice in most instances.