Browsing by Author "Rai, Arpita"

Now showing 1 - 6 of 6
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    Dentigerous Cyst: Cone Beam Computed Tomography Findings Of A Case
    (Longdom Publishing SL, 2017-09) Rai, Arpita; Vaishali, Vanita
    Background: Dentigerous cyst is a common odontogenic cyst associated with impacted tooth. Imaging of this entity poses a challenge. Case details: We present an interesting case of dentigerous cyst in a 30-year old male patient, which developed around an impacted 13. Histological examination revealed a cyst with stratified squamous epithelium of varying thickness. Cone-beam computed tomography (CBCT) is an emerging technology finding application in all branches of dentistry. The current case report highlights the application of CBCT in the preoperative assessment of dentigerous cyst of the jaw. CBCT revealed a well defined unilocular radiolucent lesion involving right maxilla associated with impacted 13. Conclusion: The current case report describes the significant contribution of CBCT in the planning and successful surgical management of dentigerous cysts and associated impacted teeth.
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    Immunomodulatory effect of Unani polyherbal formulation - Tiryaq Wabai in mild to moderate COVID-19 patients – A randomized placebo-controlled clinical trial
    (Elsevier B.V., 2024-03) Kumar, Ansul; Khan, Mohd Saif; Ul Haque, Zeya; Rai, Arpita; Fazil, Mohammad; Rabbani, Gulam
    Background: The pathogenesis of COVID-19 includes an integrated immune-inflammatory response. Modulation of host immune responses against the SARS-CoV-2 virus might be effective therapeutic management. Various Unani formulations have an immunomodulatory effect. Objective: To explore the immunomodulatory effect and safety of Unani polyherbal drug (Tiryaq Wabai) in COVID-19 patients. Materials and methods: The current study was a randomized placebo-controlled clinical trial that included 92 mild to moderate COVID-19 patients randomized into two groups. The Unani formulation Tiryaq Wabai (2 gm orally once a day) was used as an intervention for 45 days, while the control group received a placebo. Both groups received standard care treatment. The primary outcome was 50% increment in absolute lymphocyte count (ALC). The secondary outcome was 50% increment in mean lymphocyte percentage, CD4 cells, and CD8 cell count. The mean increase in all the above parameters has also been studied. Relevant statistical tests were used to analyze the effect. Results: A statistically significant improvement in a 50% increase in ALC (p-value, 0.004), lymphocyte percentage (p-value, 0.056), CD4 (p-value, 0.005), and CD8 cell count (p-value, 0.050) was reported. Also, a significant improvement in the mean value of the lymphocyte percentage (p-value 0.0007), ALC (p-value 0.0022), CD4 cell count (p-value 0.0025), and CD8 cell count (p-value 0.0093) was observed after the treatment. One adverse event of mild grade was reported in the placebo group. The analysis of safety parameters (LFT and KFT) was normal for both groups. Conclusion: In mild to moderate COVID-19 patients, Tiryaq Wabai effectively showed immunomodulatory activity by improving ALC count, lymphocyte percentage, CD4, and CD8 cell count.
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    Nutritional deficiencies in oral potentially malignant disorders and oral squamous cell carcinoma
    (Wolters Kluwer – Medknow, 2025-03) Shamsi, Shoa; Rai, Arpita; Manjhi, Lakhan; Kumar, Amit; Mahuli, Simpy Amit; Shree, Priya; Haque, Zeya Ul; Kumari, Sneha; Alam, Md. Manauwar
    Introduction: This study investigates nutritional deficiencies as potential markers in the development of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs), including oral submucous fibrosis (OSMF). OSMF, linked to betel nut product use, has been rising in India. This study focuses on assessing iron, vitamin B12, and folate deficiencies in OSMF and OSCC patients as indicators of disease progression and potential markers. Materials and Methods: Participants from different groups were recruited and examined. Vitamin B12 and folate levels were measured using enzyme?linked immunosorbent (ELISA) assays, whereas serum iron and total iron?binding capacity (TIBC) were analyzed using clinical chemistry techniques. Statistical analyses were performed to compare these markers between groups. Results: Vitamin B12 and folate levels exhibited notable reduction in OSCC and OSMF patients in comparison to controls. Serum iron showed a decreasing trend, with no statistical significance. TIBC also exhibited variation among groups. Discussion: Vitamin B12, folate, and serum iron deficiencies were observed in OSMF and OSCC patients, potentially indicating their role in disease progression. Collagen metabolism and iron utilization were suggested as mechanisms for these deficiencies. Conclusion: Nutritional deficiencies, particularly vitamin B12 and folate, appear to be associated with OSMF and OSCC, potentially serving as markers for disease progression. This study underscores the importance of assessing these deficiencies as predictive indicators in diagnosing and managing OSCC and OPMDs. Additional investigation is necessary to substantiate and broaden the scope of these findings.
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    Pyogenic Granuloma Of Upper Lip: A Case Report
    (Longdom Publishing SL, 2017-06) Rai, Arpita; Malhotra, Monica; Kumar, Ansul; Malhotra, Varun; Dwivedi, Akhilesh
    Pyogenic granuloma is a common tumor-like growth of the oral cavity that is supposed to be non-neoplastic in nature. It is a reactional response to minor trauma or chronic irritation and due to hormonal changes. Clinically oral pyogenic granuloma is a smooth or lobulated exophytic lesion on a pedunculated or sessile base, which is mostly haemorrhagic. Although pyogenic granuloma is a non-neoplastic growth in the oral cavity, proper diagnosis, prevention, management and treatment is very important. This case report draws attention towards the uncommon location of the pyogenic granuloma on the upper lip. Surgical excision was done because of the cosmetic disfigurement and discomfort to the patient.
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    Salivary transforming growth factor beta in oral submucous fibrosis: A diagnostic and predictive marker
    (Wolters Kluwer - Medknow, 2024-01) Rai, Arpita; Parveen, Shama; Shree, Priya; Ahmed, Tanveer; Ali, Sher; Kaur, Mandeep; Sircar, Keya; Sybil, Debora; Chandra, Akhilesh
    Context: Growth factors and cytokines like transforming growth factor beta (TGF?b) play a key role in the pathogenesis of oral submucous fibrosis. Aims: To elucidate the role of Salivary TGF?b isoforms as a predictive and diagnostic marker for oral submucous fibrosis. Settings and Design: A total of 30 OSMF and 10 control patients were included in this study, and their clinic?epidemiological data was recorded. Methodology: The expression of TGF?b genes—TGF?b1, TGF?b2, TGF?b3—was studied by a real?time polymerase chain reaction in tissue and saliva. Patients were given medicinal intervention for 12 weeks along with jaw?opening exercises. Expression of salivary TGF?b genes was studied at 12 weeks. Statistical Analysis Used: SPSS software version 20. Result: Expression of salivary TGF beta isoforms in OSMF was more than in the control group. There was an increase in salivary TGF?b1, b2, b3 expressions with increasing clinical grades of OSMF and advancing the stage of the disease. Expression of all the TGF beta isoforms was decreased after treatment with statistically significant results. Statistically significant correlations were found between the mean difference of TGF?b1 and the mean difference between mouth opening and tongue protrusion. Conclusion: Salivary TGF?b isoforms may be used in diagnosis, risk assessment, and screening of the entire population at risk of OSMF after its clinical validation. However, adequate sample size and segmental assessment of the expression of TGF?b isoforms are needed for further evaluation.
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    Stress Related Oral Disorders: An Update
    (Longdom Publishing SL, 2017-12) Rai, Arpita; Kumar, Ansul
    Oral changes with psychosomatic etiology are still an insufficiently confirmed and investigated subgroup of psychosomatic diseases which have long been known in medicine. In their daily practice dentists frequently come across patients showing signs of stress and their oral manifestations in form of recurrent oral stomatitis, oral lichen planus and temporomandibular disorders. Recognition of such psychological or emotional disturbance benefits both the patient and clinician. Hence psychological management should be taken into consideration when treating patients with these psychosomatic disorders.