Browsing by Author "Qureshi, W."

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    Electrocardiographic pattern in hypertensive disorders of pregnancy
    (Medip Academy, 2023-11) Khan, J. A.; Ashraf, A.; Fayaz, F.; Qureshi, W.
    Background: Hypertensive disorders of pregnancy are a major cause of poor pregnancy outcome and complicate ~6-11% of all pregnancies. When diagnosed during pregnancy, hypertension disorders escalate the maternal risk of placental abruption, cerebrovascular accident and disseminated intravascular coagulation, as well as fetal risk of intrauterine growth restriction, intrauterine death and prematurity. Interpretation of the ECG is an important component in the assessment of cardiovascular adaptations during pregnancy. Methods: In this study, 105 pregnant women (gestational age >20 weeks) with hypertensive disorders of pregnancy (HDP) in the range of 18 to 45 years of age were recruited and compared with the equal number of age matched normotensive pregnant women. ECG parameters were compared with those of normotensive pregnant women. Results: There was left axis deviation in 28.6% in HDP group as compared to 10.5% in control group, while as 71.4% and 84.8% had normal axis in HDP and control group respectively, 4.85% in control group had right axis deviation there was statistical significant difference between the two (p<0.05). There was statistically significant difference between the two groups in ECG characteristics of T wave flattening or inversion in lead III, T wave in lead V1, V2 and V3, (p<0.05). The mean QTc interval was found to be 440.28±43.62 msec in HDP women and 417.42±21.74 msec in normotensive control pregnant women and there was statistically significant difference between the two groups (p=0.000). Conclusions: ECG abnormalities seen in patients with hypertensive disorders of pregnancy (HDP) include left axis deviation, T wave abnormalities, an alteration of ventricular repolarization as evidenced by prolongation of ECG parameters, such as QTc.
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    Liver and renal biochemical parameters in preeclampsia: a cross sectional study
    (Medip Academy, 2023-03) Khan, J. A.; Ashraf, A.; Fayaz, F.; Qureshi, W.; Sheikh, A. T.
    Background: Pre-eclampsia is a multisystem disorder of human pregnancy with a genetic predisposition. It occurs more frequently in first pregnancies and leads to elevation in blood pressure and mainly affects maternal renal, cerebral, hepatic and clotting functions. This study evaluated biomarkers of renal and liver function among preeclamptic women. Methods: This was a cross-sectional study conducted among 150 preeclamptic women and 150 normotensive healthy pregnant women in hospital. The baseline data comprising age, gestational age, and blood pressure were obtained. Serum urea, creatinine, and plasma levels of liver enzymes ALT and AST, total protein, albumin, globulin and glucose were measured. Results: The plasma total protein, and albumin in preeclamptic group were significantly decreased (p<0.05) when compared with control. There was statistically significant increase (p<0.05) in urea creatinine, glucose, serum AST, and ALT activities in preeclamptic group. Conclusions: Preeclampsia has harmful effects on renal and liver function as shown by alteration of these parameters.